Enhanced photostability, radical scavenging and antitumor activity of indole-3-carbinol-loaded rose hip oil nanocapsules

Gehrcke, Mailine; Giuliani, Laura; Ferreira, Luana Mota; Barbieri, Allanna Valentini; Sari, Marcel Henrique Marcondes; Silveira, Elita Ferreira da; Azambuja, Juliana H.; Nogueira, Cristina W.; Braganhol, Elizandra; Cruz, Letícia

doi:10.1016/j.msec.2016.12.006

Cited by 45 publications

(23 citation statements)

References 42 publications

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“…Rose oils are recommended not only for inhalation and topical application (in aromatherapy and dermatology) but also for oral administration at physiologically applicable doses. A number of studies have shown the anticancer activity of rose oils and their potential to be used as adjuncts in adjuvant therapy of tumors [ 23 , 24 ]. Rose oil is also known for its anti-HIV, antibacterial, and antioxidant properties [ 3 , 6 , 25 , 26 , 27 ].…”

Section: Introductionmentioning

confidence: 99%

Rose Flowers—A Delicate Perfume or a Natural Healer?

et al. 2021

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Plants from the Rosacea family are rich in natural molecules with beneficial biological properties, and they are widely appreciated and used in the food industry, perfumery, and cosmetics. In this review, we are considering Rosa damascena Mill., Rosa alba L., Rosa centifolia L., and Rosa gallica L. as raw materials important for producing commercial products, analyzing and comparing the main biological activities of their essential oils, hydrolates, and extracts. A literature search was performed to find materials describing (i) botanical characteristics; (ii) the phytochemical profile; and (iii) biological properties of the essential oil sand extracts of these so called “old roses” that are cultivated in Bulgaria, Turkey, India, and the Middle East. The information used is from databases PubMed, Science Direct, and Google Scholar. Roses have beneficial healing properties due to their richness of beneficial components, the secondary metabolites as flavonoids (e.g., flavones, flavonols, anthocyanins), fragrant components (essential oils, e.g., monoterpenes, sesquiterpenes), and hydrolysable and condensed tannins. Rose essential oils and extracts with their therapeutic properties—as respiratory antiseptics, anti-inflammatories, mucolytics, expectorants, decongestants, and antioxidants—are able to act as symptomatic prophylactics and drugs, and in this way alleviate dramatic sufferings during severe diseases.

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Section: Introductionmentioning

confidence: 99%

Rose Flowers—A Delicate Perfume or a Natural Healer?

et al. 2021

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“…Moreover, restrictions over the use of synthetic antioxidants such as butyl hydroxyl anisd (BHA) and butylated hydroxytoluene (BHT) in food further strengthen the concept of using naturally occurring compounds as antioxidants [ 3 ]. Recently, many researches have reported the antioxidant capacity of nature polymers and saccharides, some of which have good free radicals scavenging ability and even have anticancer activity [ 4 , 5 , 6 ]. Polysaccharides derivatives are increasingly reported for their potential applications as antioxidants or free radical scavengers [ 7 , 8 , 9 , 10 , 11 , 12 ].…”

Section: Introductionmentioning

confidence: 99%

Novel Water Soluble Chitosan Derivatives with 1,2,3-Triazolium and Their Free Radical-Scavenging Activity

Sun

et al. 2018

Marine Drugs

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Chitosan is an abundant and renewable polysaccharide, which exhibits attractive bioactivities and natural properties. Improvement such as chemical modification of chitosan is often performed for its potential of providing high bioactivity and good water solubility. A new class of chitosan derivatives possessing 1,2,3-triazolium charged units by associating “click reaction” with efficient 1,2,3-triazole quaternization were designed and synthesized. Their free radical-scavenging activity against three free radicals was tested. The inhibitory property and water solubility of the synthesized chitosan derivatives exhibited a remarkable improvement over chitosan. It is hypothesized that triazole or triazolium groups enable the synthesized chitosan to possess obviously better radical-scavenging activity. Moreover, the scavenging activity against superoxide radical of chitosan derivatives with triazolium (IC50 < 0.01 mg mL−1) was more efficient than that of derivatives with triazole and Vitamin C. In the 1,1-diphenyl-2-picrylhydrazyl (DPPH) and hydroxyl radical-scavenging assay, the same pattern were observed, which should be related to the triazolium grafted at the periphery of molecular chains.

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“…The polymer wall prevents direct contact of the drug with the tissue, which is dissolved in the oil core, helping in preventing immediate release of the drug 56,57 causing a lower percentage breakdown than that with NS. Recently, P80-coated PCL-nanocapsules were shown to protect dithranbol, 58 indole-3-carbinol, 59 Coenzyme Q10, 60 quinine, 26 and betamethasone dipropionate. 45 Furthermore, clotrimazole, acetazolamide, and quinine have been reported to demonstrate protection conferred by EUD.…”

Section: Technological Evaluation Of Quinine-loaded Nanocapsulesmentioning

confidence: 99%

<p>Effects of Surface Characteristics of Polymeric Nanocapsules on the Pharmacokinetics and Efficacy of Antimalarial Quinine</p>

Michels¹,

Maciel²,

Nakama³

et al. 2019

IJN

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Introduction: The surface charge of nanoparticles, such as nanospheres (NS) and nanocapsules (NC), has been studied with the purpose of improving the in vivo performance of drugs. The aim of this study was to develop, characterize, and evaluate the in vitro antimalarial efficacy of NCP80 and NSP80 (polysorbate coated) or NCEUD and NSEUD (prepared with Eudragit RS 100) loading quinine (QN). Methods: Formulations were prepared by the nanoprecipitation method, followed by wide physicochemical characterization. Antimalarial activity in Plasmodium berghei-infected mice and populational pharmacokinetics (PopPK) in rats were evaluated. Results: The formulations showed a nanometric range (between 138 ± 3.8 to 201 ± 23.0 nm), zeta potential (mV) of −33.1 ± 0.7 (NCP80), −30.5 ± 1 (UNCP80), −25.5 ± 1 (NSP80), −20 ± 0.3 (UNSP80), 4.61 ± 1 (NCEUD), 14.1 ± 0.9 (UNCEUD), 2.86 ± 0.3 (NSEUD) and 2.84 ± 0.6 (UNSEUD), content close to 100%, and good QN protection against UVA light. There was a twofold increase in the penetration of QN into infected erythrocytes with NC compared to that with NS. There was a significant increase in t 1/2 for all NC evaluated compared to that of Free-QN, due to changes in Vdss. PopPK analysis showed that NCP80 acted as a covariate to Q (intercompartmental clearance) and V2 (volume of distribution in the peripheral compartment). For NCEUD, V1 and Q were modified after QN nanoencapsulation. Regarding in vivo efficacy, NCEUD increased the survival of mice unlike Free-QN. Conclusion: Cationic nanocapsules modified the pharmacology of QN, presenting a potential alternative for malaria treatment.

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Enhanced photostability, radical scavenging and antitumor activity of indole-3-carbinol-loaded rose hip oil nanocapsules

Cited by 45 publications

References 42 publications

Rose Flowers—A Delicate Perfume or a Natural Healer?

Rose Flowers—A Delicate Perfume or a Natural Healer?

Novel Water Soluble Chitosan Derivatives with 1,2,3-Triazolium and Their Free Radical-Scavenging Activity

<p>Effects of Surface Characteristics of Polymeric Nanocapsules on the Pharmacokinetics and Efficacy of Antimalarial Quinine</p>

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