Enhanced stability of the bactericidal activity of nisin through conjugation with gellan gum

Peng, Xingqiao; Zhu, Lan; Wang, Zhihai; Zhan, Xi

doi:10.1016/j.ijbiomac.2020.01.164

Cited by 35 publications

(16 citation statements)

References 26 publications

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“…Nisin, an FDA-approved AMP, acts as anti-biofilm agent synergistically with conventional antibiotics against methicillin-resistant Staphylococcus aureus, Streptococcus pneumoniae, Enterococci, and Clostridium difficile (Shin et al, 2016). A recent report stated that nisin in conjugation with gellan gum, a biocompatible polysaccharide, shows promising results in biomaterial research (Peng et al, 2020).…”

Section: Anti-biofilm Biomaterials Therapymentioning

confidence: 99%

Natural Anti-biofilm Agents: Strategies to Control Biofilm-Forming Pathogens

Mishra¹,

Panda²,

et al. 2020

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Pathogenic microorganisms and their chronic pathogenicity are significant concerns in biomedical research. Biofilm-linked persistent infections are not easy to treat due to resident multidrug-resistant microbes. Low efficiency of various treatments and in vivo toxicity of available antibiotics drive the researchers toward the discovery of many effective natural anti-biofilm agents. Natural extracts and natural product-based antibiofilm agents are more efficient than the chemically synthesized counterparts with lesser side effects. The present review primarily focuses on various natural anti-biofilm agents, i.e., phytochemicals, biosurfactants, antimicrobial peptides, and microbial enzymes along with their sources, mechanism of action via interfering in the quorum-sensing pathways, disruption of extracellular polymeric substance, adhesion mechanism, and their inhibitory concentrations existing in literature so far. This study provides a better understanding that a particular natural anti-biofilm molecule exhibits a different mode of actions and biofilm inhibitory activity against more than one pathogenic species. This information can be exploited further to improve the therapeutic strategy by a combination of more than one natural anti-biofilm compounds from diverse sources.

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Section: Anti-biofilm Biomaterials Therapymentioning

confidence: 99%

Natural Anti-biofilm Agents: Strategies to Control Biofilm-Forming Pathogens

Mishra¹,

Panda²,

et al. 2020

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“…The gellan-nisin conjugate was able to tolerate a broad range of pH and temperature, and also its antibacterial duration against Staphylococcus epidermidis was improved from 48 h to 144 h under alkaline environments and from 96 h to 216 h under acidic conditions. Therefore this conjugate can be an encouraging biomaterial for wound dressings and transplant coatings [35]. Heunis et al [36] stated that the application of nisin-coated wound dressing prevented S. aureus' colonization and quickened the healing procedure.…”

Section: Ribosomally Synthesized Antimicrobial Peptides (Bacteriocins) and Bacteriocin-like Inhibitory Substances (Blis)mentioning

confidence: 99%

A Review on Microorganisms-Derived Products as Potential Antimicrobial Agents

Rani¹,

Saini²,

Bast³

et al. 2021

Preprint

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Microorganisms including actinomycetes, archaea, bacteria, fungi, yeast, and micro algae are the auspicious source of vital bioactive compounds. In this review, the existing state of the art re-garding antimicrobial molecules from microorganisms has been summarized. The potential an-timicrobial compounds from actinomycetes, particularly Streptomyces sp.; archaea; fungi including endophytic and marine-derived fungi, mushroom; yeast, and microalgae were briefly described. Furthermore, this review briefly summarized the activity and mode of action of bacteriocins, a ribosomally synthesized antimicrobial peptides product of Eurotium sp., Streptomyces parvulus, S. thermophiles, Lactococcus lactis, etc. Bacteriocins have inherent properties such as targeting multi-ple-drug resistant pathogens, which allows them to be considered next-generation antibiotics. Similarly, Glarea lozoyensis derived antifungal lipohexpeptides i.e., pneumocandins, inhibits 1,3-β-glucan synthase of the fungal cell wall and acts as a precursor for the synthesis of caspo-fungin, is also elaborated. In conclusion, this review highlights the possibility of using microor-ganisms as an antimicrobial resource for biotechnological, nutraceutical, and pharmaceutical ap-plications. However, more investigations are still required to separate, purify, and characterize these bioactive compounds and transfer these primary drugs into clinically approved antibiotics.

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“…The antibacterial constancy of nisin was successfully enhanced after its conjugation with gellan. Therefore, this conjugate can be an encouraging biomaterial for wound dressings and transplant coatings [43]. A study revealed the proficiency of nisin in combination with polymyxin in combating P. aeruginosa biofilms and reducing the dose of polymyxin required to interrupt P. aeruginosa biofilms [44].…”

Section: Ribosomally Synthesized Antimicrobial Peptides (Bacteriocins) and Bacteriocin-like Inhibitory Substances (Blis)mentioning

confidence: 99%

A Review on Microbial Products and Their Perspective Application as Antimicrobial Agents

et al. 2021

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Microorganisms including actinomycetes, archaea, bacteria, fungi, yeast, and microalgae are an auspicious source of vital bioactive compounds. In this review, the existing research regarding antimicrobial molecules from microorganisms is summarized. The potential antimicrobial compounds from actinomycetes, particularly Streptomyces spp.; archaea; fungi including endophytic, filamentous, and marine-derived fungi, mushroom; and microalgae are briefly described. Furthermore, this review briefly summarizes bacteriocins, halocins, sulfolobicin, etc., that target multiple-drug resistant pathogens and considers next-generation antibiotics. This review highlights the possibility of using microorganisms as an antimicrobial resource for biotechnological, nutraceutical, and pharmaceutical applications. However, more investigations are required to isolate, separate, purify, and characterize these bioactive compounds and transfer these primary drugs into clinically approved antibiotics.

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Enhanced stability of the bactericidal activity of nisin through conjugation with gellan gum

Cited by 35 publications

References 26 publications

Natural Anti-biofilm Agents: Strategies to Control Biofilm-Forming Pathogens

Natural Anti-biofilm Agents: Strategies to Control Biofilm-Forming Pathogens

A Review on Microorganisms-Derived Products as Potential Antimicrobial Agents

A Review on Microbial Products and Their Perspective Application as Antimicrobial Agents

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