Enhancement of Apatite Precipitation on an Alkaline Hydrolyzed Poly (Lactic acid-ε-Caprolactone) Film in Simulated Body Fluid

Abstract

Biodegradable materials, such as poly (lactic acid) (PLA), have been applied to regenerate bone. However, pure PLA is brittle, so it can be modified by blending -caprolactone (PCL). These biodegradable materials have no known functional activity. In the present study, a copolymer of PLA/PCL (PLCL) film was fabricated by dissolving the materials in chloroform. Carboxylic acid groups (COOH) of PLCL were chemically introduced onto the PLCL film surface by 0.5N NaOH hydrolysis. Apatite formation was evaluated on an alkaline hydrolyzed PLCL film (PLCL-COOH) after immersion in Hanks' balanced salt solution (HBSS, pH7.4) without organic species. Water adsorption in (PBS) PLCL-COOH phosphate buffered saline was also monitored by comparing PLCL. PLCL-COOH provided a greater degree of apatite precipitation than PLCL after 3 and 7-day immersion. Weight loss was significantly different between PLCL-COOH and PLCL films from 3 days until 124 days of immersion in PBS (p<0.05). The contact angle of the PLCL-COOH surface with respect to double distilled water significantly decreased compared with PLCL (p<0.05). Thus, it was predicted that PLCL-COOH would show a better biological response and be applicable in new types of dental materials in dental treatment.

Effect of Alkaline–hydrolyzed Bioactive Poly（Lactic Acid-ε-caprolactone）Film on Apatite Precipitation in Simulated Body Fluid

“…The PLCL50 -COOH films indicated a greater amount of precipitation than the PLCL50 films at 3 and 7 days. This result was agree with studies by Tsurumi et al (17) . They suggested that the surface carboxylic groups on the film that were introduced by NaOH treatment promoted apatite precipitation.…”

Effects of dicumyl peroxide on cross‐linking pure poly(butylene succinate) foaming materials for high expansion and high mechanical strength

“…When the solution's pH increased to 13, weight losses were increased to 4.62%, 9.93%, 80.21%, and 62.16% furtherly. The main reason for this phenomenon was that the ester bond of PBS was easier hydrolyzed in an alkaline solution 40 . In addition, the weight loss of A5 and A0′ was higher than A0 and A2 because the foaming structure enlarged surface area .…”

“…The main reason for this phenomenon was that the ester bond of PBS was easier hydrolyzed in an alkaline solution. 40 In addition, the weight loss of A5 and A0 0 was higher than A0 and A2 because the foaming structure enlarged surface area .41,42 The weight loss of A5 was higher than A0', and the weight loss of A2 was higher than A0. These phenomena indicated that cross-linking structure did not effect on PBS ester bond degradation.…”

Review of Synthetic and Hybrid Scaffolds in Cartilage Tissue Engineering

“…One of them is an unexpected degradation time, which can cause brittleness of the scaffolds, even during culturing [ 59 ]. One example is PLA, which can be influenced by the use of a PLA copolymer with PCL or PEG and will affect the quality of the material [ 107 , 110 , 114 ]. Synthetic materials also lack desirable biological properties [ 115 ].…”