Enhancement of Fluorescent Probe Penetration into Tumors In Vivo Using Unseeded Inertial Cavitation

Microbubbles, Nanodroplets and Gas-Stabilizing Solid Particles for Ultrasound-Mediated Extravasation of Unencapsulated Drugs: An Exposure Parameter Optimization Study

“…Ultrasound-induced acoustic cavitation has been proposed as a means of promoting extravasation and in situ delivery of anticancer agents (Arvanitis et al 2011;Prieur et al 2016). Acoustic cavitation refers to the dynamic response of gas and vapour cavities to an acoustic field (Coussios and Roy 2008).…”

Nucleation, mapping and control of cavitation for drug delivery

“…4a). Enhancements in drug delivery have also been achieved with inertial cavitation from endogenous nuclei 128,129,130 , but at the cost of microvascular rupture inside the tumour and extensive haemorrhage in treated areas. Cavitation agents provide a safer and more effective method of intratumoral drug delivery.…”

Highly Sensitive Fluorescence and Photoacoustic Detection of Metastatic Breast Cancer in Mice Using Dual-Modal Nanoprobes

“…Meanwhile, Siegwart et al reported size-controlled pH-activatable water-soluble probes for fluorescence detection of bone and liver micrometastasis of breast cancer . Although the progression of currently available fluorescent nanoprobes for the detection of metastatic breast cancer has been highly successful, the low penetration depth and poor resolution generally limit advanced applications. − Therefore, the exploration of more feasible imaging tools and probes for the precise monitoring of the metastatic status of breast cancer remains a critical, albeit unmet, scientific goal.…”