Enhancement of Gingival Wound Healing by Local Application of Silver Nanoparticles Periodontal Dressing Following Surgery: A Histological Assessment in Animal Model

Habiboallah, Ghanbari; Mahdi, Zakery; Majid, Zakeri; Saghravanian, Nasrollah; Taghavi, Amir Moeen; Forouzanfar, Ali; Arjmand, Nooshin

doi:10.4236/mri.2014.33016

Cited by 32 publications

(19 citation statements)

References 27 publications

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“…The presence of these cells is in favor of tissue remodeling and wound healing. Similar results were observed by Habiboallah et al () in rabbit model of gingival wound healing. In our previous study performed on normal mice, macrophages and histiocytes predominated in wounds treated with FKDP dressing.…”

Section: Discussionsupporting

confidence: 91%

Evaluation of keratin biomaterial containing silver nanoparticles as a potential wound dressing in full‐thickness skin wound model in diabetic mice

Konop

Czuwara

Kłodzińska

et al. 2020

J Tissue Eng Regen Med

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Keratin is a cytoskeletal scaffolding protein essential for wound healing and tissue recovery. The aim of the study was to evaluate the potential role of insoluble fur keratin‐derived powder containing silver nanoparticles (FKDP‐AgNP) in the allogenic full‐thickness surgical skin wound model in diabetic mice. The scanning electron microscopy image evidenced that the keratin surface is covered by a single layer of silver nanoparticles. Data obtained from dynamic light scattering and micellar electrokinetic chromatography showed three fractions of silver nanoparticles with an average diameter of 130, 22.5, and 5 nm. Microbiologic results revealed that the designed insoluble FKDP‐AgNP dressing to some extent inhibit the growth of Escherichia coli and Staphylococcus aureus. In vitro assays showed that the FKDP‐AgNP dressing did not inhibit fibroblast growth or induce hemolysis. In vivo studies using a diabetic mice model confirmed biocompatible properties of the insoluble keratin dressings. FKDP‐AgNP significantly accelerated wound closure and epithelization at Days 5 and 8 (p < .05) when compared with controls. Histological examination of the inflammatory response documented that FKDP‐AgNP‐treated wounds contained predominantly macrophages, whereas their untreated variants showed mixed cell infiltrates rich in neutrophils. Wound inflammatory response based on macrophages favors tissue remodeling and healing. In conclusion, the investigated FKDP‐AgNP dressing consisting of an insoluble fraction of keratin, which is biocompatible, significantly accelerated wound healing in a diabetic mouse model.

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Section: Discussionsupporting

confidence: 91%

Evaluation of keratin biomaterial containing silver nanoparticles as a potential wound dressing in full‐thickness skin wound model in diabetic mice

Konop

Czuwara

Kłodzińska

et al. 2020

J Tissue Eng Regen Med

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“…AgNPs are also known to have unique properties in terms of toxicity, surface plasmon resonance, and electrical resistance. Based on these, intensive works have been conducted to investigate their properties and potential applications for several purposes such as antimicrobial agents in wound dressings, anticancer agents, electronic devices, and water treatment …”

Section: Introductionmentioning

confidence: 99%

A Review of Silver Nanoparticles: Research Trends, Global Consumption, Synthesis, Properties, and Future Challenges

Syafiuddin

Salmiati

Salim

et al. 2017

J Chinese Chemical Soc

342

176

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Silver nanoparticles (AgNPs) are intensively investigated for their superior physical, chemical, and biological properties. A proper knowledge of these properties is essential to maximizing the potential applications of AgNPs in several areas while minimizing their risks to humans and the environment. This paper aims to critically review AgNPs from the perspectives of research trends, global consumption, synthesis, properties, and future challenges. Generally, AgNPs can be synthesized using three methods, namely physical, chemical, and biological, and the related works as well as their numerous advantages and disadvantages are presented in this review. In addition, AgNPs can be potentially explored for various applications. Future challenges on (AgNP) synthesis, their release into the environment, and scaling up production, as presented in the review, suggest that several potential topics for future works are available to promote a safer and more efficient use of these nanoparticles. Studies on AgNPs in Malaysia have increased since the Malaysian government officially established a directorate for nanotechnology development. This calls for a proper set of policies on AgNPs starting from their production to utilization as well as their effects on various related industries and the environment.

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“…Previously, the periodontal dressing containing silver Nano particles (NP) histologically can accelerate the gingival wound healing based on inflammatory parameters. 6 Another method used to evaluate the inflammatory is nuclear medicine diagnostic. It uses the radiopharmaceutical to trace the inflammation and infection site by emitting the radiation which will be captured by detector.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Silver Nanoparticles Addition in Periodontal Dressing For Wound Tissue Healing By 99mTc-ciprofloxacin

Prasetyo¹,

Sugiharti²,

Mahendra³

et al. 2018

JYP

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Objective: Periodontal dressing is a protective material that is used on post-surgical periodontal to protect the surface of the wound and provides a comfort sense to patient. This study was conducted to determine the effect of periodontal dressings containing silver nanoparticles by evaluating inflammatory parameters using 99m Tc-ciprofloxacin; a radiopharmaceutical that can be used for diagnosing infection and inflammation. Methods: This research was carried out using purely experimental 24 male Sprague Dawley rats and divided into 4 groups. First group is a group without any treatment, second group was the positive control group (excision procedure and given CoePak(R)), third group was negative group (only excision procedure) and fourth group (excision procedure and given CoePak (R) with silver nanoparticles). On second and fourth days after the procedure, each group was observed of inflammation inside of the excision by injecting 99m Tc-ciprofloxacin through vein and after one hour the rat was sacrificed and dextra palate organ of each rat was counted by Single Channel Analyzer to determine the accumulation of 99m Tc-ciprofloxacin. Results: In rats given CoePak (R) with silver nanoparticles showed a tendency or inclination data which is good in giving effect to promote healing compare to positive control group on day 4 with less accumulation of 99m Tc-ciprofloxacin in dextra palate. Conclusion: Addition of silver nanoparticles in periodontal dressing gave a good effect for wound tissue healing.This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.

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Enhancement of Gingival Wound Healing by Local Application of Silver Nanoparticles Periodontal Dressing Following Surgery: A Histological Assessment in Animal Model

Abstract: Engineering Drive 3, Singapore 117576 † Electronic supplementary information (ESI) available: Experimental and characterization details and SEM images of the TiO 2 obtained from TiO 2 -SiO 2 composite nanobers. See

Cited by 32 publications

References 27 publications

Evaluation of keratin biomaterial containing silver nanoparticles as a potential wound dressing in full‐thickness skin wound model in diabetic mice

Evaluation of keratin biomaterial containing silver nanoparticles as a potential wound dressing in full‐thickness skin wound model in diabetic mice

A Review of Silver Nanoparticles: Research Trends, Global Consumption, Synthesis, Properties, and Future Challenges

Evaluation of Silver Nanoparticles Addition in Periodontal Dressing For Wound Tissue Healing By 99mTc-ciprofloxacin

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