Evaluation of Silver Nanoparticles Addition in Periodontal Dressing For Wound Tissue Healing By 99mTc-ciprofloxacin

Abstract

Objective: Periodontal dressing is a protective material that is used on post-surgical periodontal to protect the surface of the wound and provides a comfort sense to patient. This study was conducted to determine the effect of periodontal dressings containing silver nanoparticles by evaluating inflammatory parameters using 99m Tc-ciprofloxacin; a radiopharmaceutical that can be used for diagnosing infection and inflammation. Methods: This research was carried out using purely experimental 24 male Sprague Dawley rats and divided into 4 groups. First group is a group without any treatment, second group was the positive control group (excision procedure and given CoePak(R)), third group was negative group (only excision procedure) and fourth group (excision procedure and given CoePak (R) with silver nanoparticles). On second and fourth days after the procedure, each group was observed of inflammation inside of the excision by injecting 99m Tc-ciprofloxacin through vein and after one hour the rat was sacrificed and dextra palate organ of each rat was counted by Single Channel Analyzer to determine the accumulation of 99m Tc-ciprofloxacin. Results: In rats given CoePak (R) with silver nanoparticles showed a tendency or inclination data which is good in giving effect to promote healing compare to positive control group on day 4 with less accumulation of 99m Tc-ciprofloxacin in dextra palate. Conclusion: Addition of silver nanoparticles in periodontal dressing gave a good effect for wound tissue healing.This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.

Efficacy of silver nanoparticles in chronic periodontitis patients: a clinico-microbiological study

“…The mean gingival index showed statistically significant (p<0.05) reduction in Group A from baseline to 3 months. This can be correlated to Prasetyo BC et al [18] who concluded that Coe-Pak dressings with the addition of silver nanoparticles tended to give better results in tissue healing due to anti-inflammatory and antimicrobial properties of silver nanoparticles. Similar, antiinflammatory and antimicrobial effects of silver nanoparticles were demonstrated by Habiboallah G et al [19].…”

Silver-Deposited Nanoparticles on the Titanium Nanotubes Surface as a Promising Antibacterial Material into Implants

“…There are some side-effects which can consist of adverse tissue reactions and depend on the size and type of the NP Ag [103]. As a side effect, Pokrowiecki noticed a significant decrease in the viability of the cells after exposing human osteoblasts to 0.1 ppm of silver ions by using ToxiLight™ BioAssay Kit after 72 h. The cytotoxic and antibacterial activity can be observed at similar concentration [108].…”

“…There are some side-effects which can consist of adverse tissue reactions and depend on the size and type of the NP Ag [88,103].…”

Recent progress in materials development and biological properties of GTR membranes for periodontal regeneration

“…AgNPs were described to contains an antimicrobial influence, by growth factors (Singh et al, 2018). To treat gingival wounds, periodontal treatment coated with AgNPs can be applied (Prasetyo et al, 2019;Yin et al, 2020). AgNPs can be mixed with acrylic resin to stop the development of pathogenic bacterial species like Staphylococcus aureus, E. coli, and Streptococcus mutants (de Castro et al, 2018;Yin et al, 2020).…”