The MIMO technique is an essential element in the standards of communication systems (IEEE 802.11n, IEEE 802.11ac, WiMAX, and LTE) because it helps to increase their capacity. This paper employs a model order reduction (MOR) technique with a PID controller, an ACO algorithm, and the ITAE fitness function to reduce the large-scale linearity of the MIMO technique. The numerator and denominator parameters are set by minimizing the ITAE fitness function between the transient responses of the original and the reduced model. The objectives are achieved with the PID controller and the ACO algorithm for the unit step input. The simulation results show a good system performance. The controller performance is presented with regard to the dynamic response in terms of rising time, settling time, and overshoot/undershoot. Moreover, the results of the proposed method are compared with four literature reports for validation purposes. Evaluating the parameters within the time frame and the error values with and without the PID controller and ACO algorithm allowed validating the functioning of the proposed method. Furthermore, the simulation results revealed that the proposed scheme exhibited sufficient robustness and demonstrated a reduction in the time-domain response and error values.