Enhancement of Lipid Peroxidation in the Liver of Mice Exposed to Magnetic Fields.

Watanabe, Yoshihiko; Nakagawa, Masayoshi; Miyakoshi, Yuichi

doi:10.2486/indhealth.35.285

Cited by 47 publications

(28 citation statements)

References 23 publications

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“…Several other studies have shown that exposure to EMFs increased free radical formation in various tissues (Moustafa et al 2001;Zmyslony et al 2004;Simko et al 2006). This study is consistent with the previous reports, showing that EMF caused lipid peroxidation in rat liver (Watanabe et al 1997) and that EMF increased malondialdehyde formation in the rat liver and brain (Romodanova et al 1990). The present study also revealed that plasma and brain GSH levels were decreased in EMF-exposed rats, which might indicate a reduction in antioxidant defence.…”

Section: Discussionsupporting

confidence: 94%

Zinc Supplementation Ameliorates Electromagnetic Field-Induced Lipid Peroxidation in the Rat Brain

Bediz

Baltacı

Moğulkoç

et al. 2006

Tohoku J. Exp. Med.

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Extremely low-frequency (0-300 Hz) electromagnetic fields (EMFs) generated by power lines, wiring and home appliances are ubiquitous in our environment. All populations are now exposed to EMF, and exposure to EMF may pose health risks. Some of the adverse health effects of EMF exposure are lipid peroxidation and cell damage in various tissues. This study has investigated the effects of EMF exposure and zinc administration on lipid peroxidation in the rat brain. Twenty-four male Sprague-Dawley rats were randomly allocated to three groups; they were maintained untreated for 6 months (control, n = 8), exposed to low-frequency (50 Hz) EMF for 5 minutes every other day for 6 months (n = 8), or exposed to EMF and received zinc sulfate daily (3 mg/kg/day) intraperitoneally (n = 8). We measured plasma levels of zinc and thiobarbituric acid reactive substances (TBARS), and levels of reduced glutathione (GSH) in erythrocytes. TBARS and GSH levels were also determined in the brain tissues. TBARS levels in the plasma and brain tissues were higher in EMF-exposed rats with or without zinc supplementation, than those in controls ( p < 0.001). In addition, TBARS levels were significantly lower in the zinc-supplemented rats than those in the EMF-exposed rats ( p < 0.001). GSH levels were significantly decreased in the brain and erythrocytes of the EMF-exposed rats ( p < 0.01), and were highest in the zinc-supplemented rats ( p < 0.001). Plasma zinc was significantly lower in the EMF-exposed rats than those in controls ( p < 0.001), while it was highest in the zinc-supplemented rats ( p < 0.001). The present study suggests that long-term exposure to low-frequency EMF increases lipid peroxidation in the brain, which may be ameliorated by zinc supplementation. electromagnetic field; lipid peroxidation; zinc; brain

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Section: Discussionsupporting

confidence: 94%

Zinc Supplementation Ameliorates Electromagnetic Field-Induced Lipid Peroxidation in the Rat Brain

Bediz

Baltacı

Moğulkoç

et al. 2006

Tohoku J. Exp. Med.

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“…We also previously reported the suppression or enhancement of the genotoxic effects in microbial systems, cultured cells and animals, the suppression of food and water consumption and body weight in mice, and the enhancement of metallothionein content and lipid peroxidation in mice, with exposure to strong static EMFs (0.15-to 11.75-T) alone or co-exposure to static EMFs and chemicals (38)(39)(40)(41)(42)(43). Our previous studies suggested that the effects induced by strong static EMFs may be enhanced or suppressed by the stress reaction or cell cycle change.…”

Section: Discussionmentioning

confidence: 94%

The frequencies of micronuclei induced by cisplatin in newborn rat astrocytes are increased by 50-Hz, 7.5- and 10-mT electromagnetic fields

Miyakoshi

Yoshioka

Toyama

et al. 2005

Environ Health Prev Med

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Objectives: Epidemiological studies have suggested that exposure to environmental and occupational electromagnetic fields (EMFs) contribute to the induction of brain tumors, leukemia, and other neoplasms. The aim of this study was to investigate the genotoxic effects of exposure to 50-Hz EMFs, and of co-exposure to cisplatin, a mutagen and carcinogen, and 50-Hz EMFs, using an in vivo newborn rat astrocyte micronucleus assay.Methods: Three day-old male Sprague-Dawley rats were co-exposed to 50-Hz EMFs and 1.25 or 2.5 mg/kg of cisplatin. Brain cells were dissociated into single cells and cultured for 96 hours, then stained with acridine orange and an antibody against glial fibrillary acidic protein. The frequency of micronucleated astrocytes was counted with a fluorescent microscope.Results: The frequency of micronuclei was not increased in rat astrocytes exposed to EMFs alone. However, the frequencies of micronuclei in co-exposure to 2.5 mg/kg cisplatin and EMFs (7.5-and 10-mT) were significantly increased, compared with those in exposure to 2.5 mg/kg cisplatin alone (shamexposure, 0-mT EMFs) for 72 hours (p<0.01).Conclusion: Exposure to EMFs alone did not have a genotoxic effect but co-exposure to EMFs increased the genotoxic activity induced by cisplatin. Our findings suggest that EMFs enhance the genotoxic effects of cisplatin.

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“…In the group exposed to EMF for 18 months in that study, irregularity was observed in sinusoidal lumen diameters, the cell cytoplasm was empty and replaced by granules, chromatin was less condensed, and the space between the interior and exterior nuclear membrane expanded (29). Another study referred to EMF altering mitochondrial structures, particularly in hepatocytes (30).…”

Section: Discussionmentioning

confidence: 99%

“…MDA and SOD levels have been reported to increase and GSH to decrease in rats exposed to EMF at a frequency of 945 MHz and with a SAR value of 11.3 mW/ kg (31). High-frequency 4.7-T EMF has been shown to lead to LPO in mice by increasing TBARS (30).…”

Section: Discussionmentioning

confidence: 99%

The effects of prenatal long-duration exposure to 900-MHz electromagnetic field on the 21-day-old newborn male rat liver

Topal¹,

Hancı²,

Mercantepe³

et al. 2015

Turk J Med Sci

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Background/aim:To determine what effect a 900-MHz electromagnetic field (EMF) applied in the prenatal period would have on the liver in the postnatal period. Materials and methods:At the start of the study, adult pregnant rats were divided into two groups, control and experimental. The experimental group was exposed to a 900-MHz EMF for 1 h daily during days 13-21 of pregnancy. After birth, no procedure was performed on either mothers or pups. Male rat pups (n = 6) from the control group mothers (CGMR) and male rat pups (n = 6) from the experimental group mothers (EGMR) were sacrificed on postnatal day 21.Results: Biochemical analyses showed that malondialdehyde and superoxide dismutase values increased and glutathione levels decreased in the EGMR pups. Marked hydropic degeneration in the parenchyma, particularly in pericentral regions, was observed in light microscopic examination of EGMR sections stained with hematoxylin and eosin. Examinations under transmission electron microscope revealed vacuolization in the mitochondria, expansion in the endoplasmic reticulum, and necrotic hepatocytes. Conclusion:The study results show that a 900-MHz EMF applied in the prenatal period caused oxidative stress and pathological alterations in the liver in the postnatal period.

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Enhancement of Lipid Peroxidation in the Liver of Mice Exposed to Magnetic Fields.

Cited by 47 publications

References 23 publications

Zinc Supplementation Ameliorates Electromagnetic Field-Induced Lipid Peroxidation in the Rat Brain

Zinc Supplementation Ameliorates Electromagnetic Field-Induced Lipid Peroxidation in the Rat Brain

The frequencies of micronuclei induced by cisplatin in newborn rat astrocytes are increased by 50-Hz, 7.5- and 10-mT electromagnetic fields

The effects of prenatal long-duration exposure to 900-MHz electromagnetic field on the 21-day-old newborn male rat liver

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