Enhancement of protein detection performance in field-effect transistors with polymer residue-free graphene channel

Jung, Jin Heak; Sohn, Il Yung; Kim, Duck Jin; Kim, Bo Yeong; Jang, Mi; Lee, Nae‐Eung

doi:10.1016/j.carbon.2013.05.069

Cited by 17 publications

(24 citation statements)

References 56 publications

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“…Meanwhile, this article may stimulate further developments of highly sensitive GFETs in biological field. Similarly, Jung used Au mediator instead of PMMA to transfer graphene from Cu foil to Si/SiO 2 substrate, and demonstrated that Au‐transferred graphene based FET without polymer residue significantly enhanced carbohydrate antigen 19–9 (a pancreatic cancer biomarker) detection sensitivity compared with that of PMMA‐transferred based FET.…”

Section: Effects Of Surface Defects and Residues Of Gfets On Performamentioning

confidence: 99%

Graphene Field‐Effect Transistor and Its Application for Electronic Sensing

Zhan

Yang

et al. 2014

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Graphene, because of its excellent mechanical, electrical, chemical, physical properties, sparked great interest to develop and extend its applications. Particularly, graphene based field-effect transistors (GFETs) present exciting and bright prospects for sensing applications due to their greatly higher sensitivity and stronger selectivity. This Review highlights a selection of important topics pertinent to GFETs and their application in electronic sensors. This article begins with a description of the fabrications and characterizations of GFETs, and then introduces the new developments in physical, chemical, and biological electronic detection using GFETs. Finally, several perspective and current challenges of GFETs development are presented, and some proposals are suggested for further development and exploration.

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Section: Effects Of Surface Defects and Residues Of Gfets On Performamentioning

confidence: 99%

Graphene Field‐Effect Transistor and Its Application for Electronic Sensing

Zhan

Yang

et al. 2014

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237

161

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“…Graphene devices are also promising for sensing biomarkers, which are indicators of a particular biological disorder. For example, a pancreatic cancer biomarker (CA 19–9) was detected through the development of graphene‐based FET by Jung and co‐workers . By using specific antibodies, detection of amyloid beta peptides have been demonstrated directly in liquid on RGO sensors .…”

Section: Miniaturized Bioelectronics On‐chipmentioning

confidence: 99%

Bioelectronics and Interfaces Using Monolayer Graphene

et al. 2018

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Graphene is expected to revolutionize several application areas ranging from portable energy conversion and storage to miniaturized biosensors for medical applications. In this endeavor, the control of surface characteristics is an essential aspect for understanding fundamental phenomena occurring at the graphene‐liquid interface. In this comprehensive review, we address recent progress in the investigation of the interfacial characteristics of monolayer graphene and methods for modulating the physical and chemical properties of this interface. We focus on the electrochemistry and field‐effect measurements in liquid, which provide an improved understanding of the unique graphene‐liquid interface, with due consideration of the influence of the underlying substrate and structural defects in graphene. Finally, we present reported examples of using single graphene monolayers in miniaturized devices for realizing sensors, neural interfaces and batteries.

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“…The lowest detection limit of PSA was achieved by a FET device based on SiNW (1 fg·mL −1 ) [47]. Detection of tumor biomarkers for breast cancer [52,53], hepatic carcinoma [54], oral squamous cell carcinoma [55], pancreatic cancer [56], and bladder cancer [57] have also been reported. Moreover, other disease biomarkers related to cardiovascular diseases [58][59][60], thyroid hormone [61], venous thromboembolism [62], Alzheimer [63], and diabetes [64,65] have been detected with very low detection limits.…”

Section: Trends In Fet-based Immunosensors Using Nanomaterials As Senmentioning

confidence: 99%

“…Table 2 also depicts the application of immunoFET devices for detecting environmental contaminants such as pesticides [74], herbicides [75], toxins [76], and phytopathogens [77]. Alzheimer biomarker, amyloid-β SWCNT 10 −12 -10 −9 g·mL −1 1 pg·mL −1 in human serum [63] Chondroitin sulfate proteoglycan 4, multiple cancer types biomarker Graphene 0.01 fM-10 pM 0.01 fM [85] Pancreatic cancer biomarker, carbohydrate antigen 19-9 (CA 19-9) Graphene 0.01 unit·mL −1 -1000 unit·mL −1 0.01 unit·mL −1 [56] Prostate specific antigen/α1-antichymotrypsin (PSA-ACT) complex Graphene 100 fg·mL −1 -1 µg·mL −1 100 fg·mL −1 [49] Breast cancer biomarkers human epidermal growth factor receptor 2 (HER2) and epidermal growth factor receptor (EGFR) SiO 2 /graphene 100 pM-1 µM 1 pM for HER2 and 100 pM for EGFR [52] Human immunodeficiency virus (HIV) 2,4-Dichlorophenoxyacetic acid herbicides SWCNT 5 fM-500 µM 500 fM in soil sample and 50 pM in buffer [75] 2,4,6-Trinitrotoluene (TNT) contamination SWCNT 0.5 ppb-5000 ppb 0.5 ppb [76] Microcystin-LR (cyanotoxin in surface waters) SWCNT 1-1000 ng·L −1 0.6 ng·L −1 [91] Citrus tristeza virus and Xylella fastidiosa phytopathogens InP 60-340 ng·mL −1 for Citrus tristeza virus and 34-250 ng·mL −1 for Xylella fastidiosa 2 nM for both phytopathogens [77] 3.1. Silicon Nanowires…”

Section: Trends In Fet-based Immunosensors Using Nanomaterials As Senmentioning

confidence: 99%

“…Graphene was grown by chemical vapor deposition (CVD) technique and transferred by a novel method to the sensor substrate, free from remaining polymer residues. The cleaner surface resulted in higher p-doping, higher channel mobility, and significantly enhanced sensitivity [56]. Prostate cancer biomarker, PSA/α-1-antichymotrypsin (PSA-ACT) complex, was detected by a FET sensor based on reduced graphene oxide (RGO), a chemically derived graphene [49].…”

Section: Graphenementioning

confidence: 99%

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Recent Trends in Field-Effect Transistors-Based Immunosensors

Moraes

Kubota

2016

Chemosensors

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Abstract:Immunosensors are analytical platforms that detect specific antigen-antibody interactions and play an important role in a wide range of applications in biomedical clinical diagnosis, food safety, and monitoring contaminants in the environment. Field-effect transistors (FET) immunosensors have been developed as promising alternatives to conventional immunoassays, which require complicated processes and long-time data acquisition. The electrical signal of FET-based immunosensors is generated as a result of the antigen-antibody conjugation. FET biosensors present real-time and rapid response, require small sample volume, and exhibit higher sensitivity and selectivity. This review brings an overview on the recent literature of FET-based immunosensors, highlighting a diversity of nanomaterials modified with specific receptors as immunosensing platforms for the ultrasensitive detection of various biomolecules.

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Enhancement of protein detection performance in field-effect transistors with polymer residue-free graphene channel

Cited by 17 publications

References 56 publications

Graphene Field‐Effect Transistor and Its Application for Electronic Sensing

Graphene Field‐Effect Transistor and Its Application for Electronic Sensing

Bioelectronics and Interfaces Using Monolayer Graphene

Recent Trends in Field-Effect Transistors-Based Immunosensors

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