Enhancement of Skin Permeation of a Hydrophilic Drug from Acryl-Based Pressure-Sensitive Adhesive Tape

Suzuki, Takamasa; Aoki, Tomohiro; Saito, Masato; Hijikuro, Ichiro; Itakura, Shoko; Todo, Hiroaki; Sugibayashi, Kenji

doi:10.1007/s11095-021-02996-z

Cited by 6 publications

(7 citation statements)

References 30 publications

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“…In the present study, the interaction of LA with MGE was also confirmed by NMR observation. Several reports have been published that improved drug permeation by MGE was caused by increased membrane fluidity [21]. Furthermore, enhancement of the effect by MGE was higher in forming an unorganized state than in constructing an NLLC structure [21].…”

Section: Discussionmentioning

confidence: 98%

“…Several reports have been published that improved drug permeation by MGE was caused by increased membrane fluidity [21]. Furthermore, enhancement of the effect by MGE was higher in forming an unorganized state than in constructing an NLLC structure [21]. Thus, an increase in the lipophilicity provided by a weak interaction with the hydrophilic moieties of MGE and LA and the permeation enhancement effect by MGE might be reasons for the improvement of blood transfer from the injection site.…”

Section: Discussionmentioning

confidence: 99%

“…Recently, mono-O-(5,9,13-trimethyl-4-tetradecenyl) glycerol ester (MGE), an amphiphilic material, has gained attention as a novel additive to improve drug absorption. A formulation containing MGE enhanced direct nose-to-brain migration of an entrapped drug [20] and increased the transdermal permeation of a hydrophilic drug by altering membrane fluidity [21]. Therefore, the incorporation of MGE in a vehicle might be effective in improving the BA of middle and high molecular weight peptides by enhancing their migration into the systemic circulation.…”

Section: Introductionmentioning

confidence: 99%

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Development of Self-Administered Formulation to Improve the Bioavailability of Leuprorelin Acetate

et al. 2022

Self Cite

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In recent years, the development of self-injectable formulations has attracted much attention, and the development of formulations to control pharmacokinetics, as well as drug release and migration in the skin, has become an active research area. In the present study, the development of a lipid-based depot formulation containing leuprorelin acetate (LA) as an easily metabolizable drug in the skin was prepared with a novel non-lamellar liquid-crystal-forming lipid of mono-O-(5,9,13-trimethyl-4-tetradecenyl) glycerol ester (MGE). Small-angle X-ray scattering, cryo-transmission electron microscopy, and nuclear magnetic resonance observations showed that the MGE-containing formulations had a face-centered cubic packed micellar structure. In addition, the bioavailability (BA) of LA after subcutaneous injection was significantly improved with the MGE-containing formulation compared with the administration of LA solution. Notably, higher Cmax and faster Tmax were obtained with the MGE-containing formulation, and the BA increased with increasing MGE content in the formulation, suggesting that LA migration into the systemic circulation and its stability might be enhanced by MGE. These results may support the development of self-administered formulations of peptide drugs as well as nucleic acids, which are easily metabolized in the skin.

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Development of Self-Administered Formulation to Improve the Bioavailability of Leuprorelin Acetate

et al. 2022

Self Cite

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“…These devices performed the analysis at the micro-scale (micro-channels, micro-arrays, micro-pumps, etc. ). , The LOC integrates into one reaction platform all the processes associated with the detection, from the placement of the sample into the chip to the analysis. , One can visualize major research efforts toward developing such multifunctional MN arrays by combining electrochemical sensors and drug release actuators. In contrast to epidermal patches, the MN devices pierce and penetrate through the upper skin layers.…”

Section: Minimally Invasive Microneedle Glucose Monitoringmentioning

confidence: 99%

Skin Patchable Sensor Surveillance for Continuous Glucose Monitoring

Manasa¹,

Mascarenhas²,

Shetti

et al. 2022

ACS Appl. Bio Mater.

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Diabetes mellitus is a physiological and metabolic disorder affecting millions of people worldwide, associated with global morbidity, mortality, and financial expenses. Long-term complications can be avoided by frequent, continuous self-monitoring of blood glucose. Therefore, this review summarizes the current state-of-art glycemic control regimes involving measurement approaches and basic concepts. Following an introduction to the significance of continuous glucose sensing, we have tracked the evolution of glucose monitoring devices from minimally invasive to non-invasive methods to present an overview of the spectrum of continuous glucose monitoring (CGM) technologies. The conveniences, accuracy, and cost-effectiveness of the real-time CGM systems (rt-CGMs) are the factors considered for discussion. Transdermal biosensing and drug delivery routes have recently emerged as an innovative approach to substitute hypodermal needles. This work reviews skin-patchable glucose monitoring sensors for the first time, providing specifics of all the major findings in the past 6 years. Skin patch sensors and their progressive form, i.e., microneedle (MN) array sensory and delivery systems, are elaborated, covering self-powered, enzymatic, and non-enzymatic devices. The critical aspects reviewed are material design and assembly techniques focusing on flexibility, sensitivity, selectivity, biocompatibility, and user-end comfort. The review highlights the advantages of patchable MNs' multi-sensor technology designed to maintain precise blood glucose levels and administer diabetes drugs or insulin through a "sense and act" feedback loop. Subsequently, the limitations and potential challenges encountered from the MN array as rt-CGMs are listed. Furthermore, the current statuses of working prototype glucose-responsive "closed-loop" insulin delivery systems are discussed. Finally, the expected future developments and outlooks in clinical applications are discussed.

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“…For these tasks, different membranes are used: human skin in vivo, 103 human skin ex vivo, 104,105 in vitro skin substitutes 75 and porcine skin. 52,54,106,107,108,109 Rodent skin 110 is rarely due to its inherent differences to human skin. Caffeine, 52,106,109,111,112,113 lidocaine, 104 procaine, 107,114 tetracaine, 115 salicylic acid, 113 ibuprofen, 103 flufenamic acid, 105 imiquimod, 116 trans-retinol, 117,118 resorcinol, 75 niacinamide, 119 sulfathiazole sodium, 54 triamcinolone acetonide 120 and oxaprozin are among the most investigated permeants in the CRS penetration studies.…”

Section: Skin Penetration Studiesmentioning

confidence: 99%

Novel aspects of Raman spectroscopy in skin research

Lunter

Klang

Kocsis

et al. 2022

Experimental Dermatology

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The analytical technology of Raman spectroscopy has an almost 100‐year history. During this period, many modifications and developments happened in the method like discovery of laser, improvements in optical elements and sensitivity of spectrometer and also more advanced light detection systems. Many types of the innovative techniques appeared (e.g. Transmittance Raman spectroscopy, Coherent Raman Scattering microscopy, Surface‐Enhanced Raman scattering and Confocal Raman spectroscopy/microscopy). This review article gives a short description about these different Raman techniques and their possible applications. Then, a short statistical part is coming about the appearance of Raman spectroscopy in the scientific literature from the beginnings to these days. The third part of the paper shows the main application options of the technique (especially confocal Raman spectroscopy) in skin research, including skin composition analysis, drug penetration monitoring and analysis, diagnostic utilizations in dermatology and cosmeto‐scientific applications. At the end, the possible role of artificial intelligence in Raman data analysis and the regulatory aspect of these techniques in dermatology are briefly summarized. For the future of Raman Spectroscopy, increasing clinical relevance and in vivo applications can be predicted with spreading of non‐destructive methods and appearance with the most advanced instruments with rapid analysis time.

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Enhancement of Skin Permeation of a Hydrophilic Drug from Acryl-Based Pressure-Sensitive Adhesive Tape

Cited by 6 publications

References 30 publications

Development of Self-Administered Formulation to Improve the Bioavailability of Leuprorelin Acetate

Development of Self-Administered Formulation to Improve the Bioavailability of Leuprorelin Acetate

Skin Patchable Sensor Surveillance for Continuous Glucose Monitoring

Novel aspects of Raman spectroscopy in skin research

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