Enhancing Cancer Immunotherapeutic Efficacy with Sonotheranostic Strategies

Zafar, Ayesha; Hasan, Murtaza; Tariq, Tuba; Dai, Zhifei

doi:10.1021/acs.bioconjchem.1c00437

Cited by 12 publications

(10 citation statements)

References 272 publications

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“…The biocompatibility, stability, surface area, morphology, and size are the distinctive properties of Au, Zn, Cu, Ni, and SiO 2 NPs . Nanomaterials have demonstrated significant promise in a wide range of fields, from technology to biological sciences and from cellular to molecular and genetic processes. − However, there is a significant gap in knowledge concerning the precise mechanism of NPs-induced oxidative stress, and little information about toxic effects of Ag-SiO 2 is available in the literature. A comparative study related to the toxic effects of C-SiO 2 , Ag-SiO 2 , and ZnO-SiO 2 has not been reported.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Characterization of Silica, Silver-Silica, and Zinc Oxide-Silica Nanoparticles for Evaluation of Blood Biochemistry, Oxidative Stress, and Hepatotoxicity in Albino Rats

et al. 2023

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Evaluation of nanoparticles (NPs) for biomedical applications has received a lot of attention for detailed study on pharmacokinetics prior to clinical application. In this study, pure C-SiO 2 (crystalline silica) NPs and SiO 2 nanocomposites with silver (Ag) and zinc oxide (ZnO) were prepared by utilizing different synthesis routes such as sol−gel and co-precipitation techniques. The prepared NPs showed highly crystalline nature as confirmed by X-ray diffraction analysis where average crystallite sizes of 35, 16, and 57 nm for C-SiO 2 , Ag-SiO 2 , and ZnO-SiO 2 NPs, respectively, were calculated. Fourier transform infrared analysis confirmed the presence of functional groups related to the chemicals and procedures used for sample preparation. Due to agglomeration of the prepared NPs, the scanning electron microscope images showed large particle sizes when compared to their crystalline sizes. The optical properties of the prepared NPs such as absorption were obtained with UV−Vis spectroscopy. For in vivo biological evaluation, albino rats, both male and female, kept in different groups were exposed to NPs with 500 μg/kg dose. Hematological, serum biochemistry, histo-architecture, oxidative stress biomarkers, and antioxidant parameters in liver tissues along with various biomarkers for the evaluation of erythrocytes were estimated. The results on hemato-biochemistry, histopathological ailments, and oxidative stress parameters exhibited 95% alteration in the liver and erythrocytes of C-SiO 2 NPs-treated rats while 75 and 60% alteration in the liver tissues of rats due to exposure to Ag-SiO 2 and ZnO-SiO 2 NPs, respectively, when compared with the albino rats of the control (untreated) group. Therefore, the current study showed that the prepared NPs had adverse effects on the liver and erythrocytes causing hepatotoxicity in the albino rats in respective order C-SiO 2 > Ag SiO 2 > ZnO-SiO 2 . As the C-SiO 2 NPs appeared to be the most toxic, it has been concluded that coating SiO 2 on Ag and ZnO reduced their toxicological impact on albino rats. Consequently, it is suggested that Ag-SiO 2 and ZnO-SiO 2 NPs are more biocompatible than C-SiO 2 NPs.

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Section: Introductionmentioning

confidence: 99%

Synthesis and Characterization of Silica, Silver-Silica, and Zinc Oxide-Silica Nanoparticles for Evaluation of Blood Biochemistry, Oxidative Stress, and Hepatotoxicity in Albino Rats

et al. 2023

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“…Few cancer types have very high predictive values and narrow signature symptoms as it is easy to diagnose it early due to its symptomatic representation whereas other types of cancer have difficulty in diagnosis due to its asymptomatic representation and low predictive values [18]. Diagnosing cancer at early stage is cost effective as its saves money [19]that is to be utilized for drug therapies for advance stage disease [20].There is no certified data available regarding symptomatic and asymptomatic representation of different types of cancer and to date, no metabolic, biochemical profiling and hematological evaluation of cancer is done from the district of Bahawalpur, Pakistan. In order to bridge the gap between evaluation and diagnosis, current work was designed with the objectives of assessing the knowledge of metabolic, biochemical profiling and hematological evaluation of cancer patients, so far to investigate the symptomatic and asymptomatic illustration of diverse types of cancers and to create awareness in the population of -district Bahawalpur.…”

Section: Introductionmentioning

confidence: 99%

Blueprinting in Coherence to Diagnostic Momentum: On Account of Cancer Detection in Bahawalpur Community

Manzoor¹,

Dilshad²,

Hassan³

et al. 2022

PJBB

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In the current era, cancer is a critical health problem. Purpose of the study was symptomatic analysis of cancer patients and medical evaluation of hematological and biochemical parameters of patients from different geographical areas of district Bahawalpur. A crosssectional study was done to find out the diagnostic timeliness in cancer patients. Out of 150 cancer patients, 53% patients were males and 47% females with age from 15 years to 75 years. It has been shown that 76% of patients represent major symptoms of cancer while 24% of patients were showing minor symptoms. Furthermore, cancer patients were disturbed metabolical, hematological, and biochemical profiling. There were 83% of patients with anemia and 17% patients have normal hemoglobin count in males and 85 % of total female patients have low hemoglobin level while rest of 15% have normal hemoglobin count. Illiteracy is positively influencing the factors responsible for causing cancer with 53%, whereas 23% less than primary level education and only 1% of patients had completed their graduation. There were 31% of the patients lies in upper lower class of society, 28% lower class, Lower middle class 19%, middle class 14%, upper middle class 7% and only 1 % patients belong to high social status. This study will help to diagnosis the early cancer detection via biochemical and metabolic profiling.

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“…The fluorescence quenching is roughly divided into three types: dynamic quenching, static quenching, and an amalgamation of the two. Vibrant quenching is due to collisions between the fluorophore and the specific quencher in an excited state, while static quenching is from the formed complex between the quencher and fluorophore. − …”

Section: Fluorescence Properties and Detection Mechanism Of Cqdsmentioning

confidence: 99%

Advances in Fluorescent Sensing Carbon Dots: An Account of Food Analysis

Tian

Zhao

et al. 2023

ACS Omega

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Illuminating the use of nanomaterials, carbon quantum dots (CQDs) have transfigured the food safety arena because of their bright luminescence, optical properties, low toxicity, and enhanced biocompatibility. Therefore, fluorescent resonance energy transfer, photoinduced electron transfer, and an internal filtering effect mechanism allow precise detection of food additives, heavy metal ions, pathogenic bacteria, veterinary drug residues, and food nutrients. In this review, we describe the primal mechanism of CQD-based fluorescence sensors for food safety inspection. This is an abridged description of the nanodesign and future perspectives of more advanced CQD-based sensors for food safety analysis.

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Enhancing Cancer Immunotherapeutic Efficacy with Sonotheranostic Strategies

Cited by 12 publications

References 272 publications

Synthesis and Characterization of Silica, Silver-Silica, and Zinc Oxide-Silica Nanoparticles for Evaluation of Blood Biochemistry, Oxidative Stress, and Hepatotoxicity in Albino Rats

Synthesis and Characterization of Silica, Silver-Silica, and Zinc Oxide-Silica Nanoparticles for Evaluation of Blood Biochemistry, Oxidative Stress, and Hepatotoxicity in Albino Rats

Blueprinting in Coherence to Diagnostic Momentum: On Account of Cancer Detection in Bahawalpur Community

Advances in Fluorescent Sensing Carbon Dots: An Account of Food Analysis

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