Enhancing structural integrity of hydrogels by using highly organised melt electrospun fibre constructs

Bas, Onur; Chhaya, Mohit P.; Wunner, Felix M.; Jeon, June; Klein, Travis J.; Hutmacher, Dietmar W.

doi:10.1016/j.eurpolymj.2015.07.034

Cited by 111 publications

(98 citation statements)

References 51 publications

(58 reference statements)

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“…Direct writing of the electrospun jet, a term coined and extensively reported by Hutmacher and Dalton’s research groups, is one such technique that focuses on directing the melt electrospun jet into localized and targeted collection [91, 92]. This is typically accomplished by an automated lateral translation of the collector with respect to the polymer melt, thus making it possible for precise control of the architecture, similar to what can be achieved by RP process [93].…”

Section: Processingmentioning

confidence: 99%

Poly (lactic acid)-based biomaterials for orthopaedic regenerative engineering

Narayanan

Vernekar

Kuyinu

et al. 2016

Advanced Drug Delivery Reviews

391

240

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Regenerative engineering converges tissue engineering, advanced materials science, stem cell science, and developmental biology to regenerate complex tissues such as whole limbs. Regenerative engineering scaffolds provide mechanical support and nanoscale control over architecture, topography, and biochemical cues to influence cellular outcome. In this regard, poly (lactic acid) (PLA)-based biomaterials may be considered as a gold standard for many orthopaedic regenerative engineering applications because of their versatility in fabrication, biodegradability, and compatibility with biomolecules and cells. Here we discuss recent developments in PLA-based biomaterials with respect to processability and current applications in the clinical and research settings for bone, ligament, meniscus, and cartilage regeneration.

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Section: Processingmentioning

confidence: 99%

Poly (lactic acid)-based biomaterials for orthopaedic regenerative engineering

Narayanan

Vernekar

Kuyinu

et al. 2016

Advanced Drug Delivery Reviews

391

240

View full text Add to dashboard Cite

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“…GEL-MA/HA-MA hydrogels/ highly oriented PCL fibers hMSCs in vitro MEW hydrogels/highly oriented fibers Improvement in mechanical properties 55 Snyder et al…”

Section: Atelocolagen/hamentioning

confidence: 99%

Reconstruction Strategies of the Ureter and Urinary Diversion Using Tissue Engineering Approaches

Janke

Jonge

Feitz

et al. 2019

Tissue Engineering Part B: Reviews

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Cartilage consists of chondrocytes and a special extracellular matrix (ECM) having unique biochemical, biophysical, and biomechanical properties that play a critical role in the proliferation and differentiation of cells inherent to cartilage functions. Cartilage tissue engineering (CTE) requires recreating these microenvironmental physicochemical conditions to lead to chondrocyte differentiation from stem cells. ECM-derived hybrid scaffolds based on chondroitin sulfate, hyaluronic acid, collagen, and cartilage ECM analogs provide environments conducive to stem cell proliferation. In this review, we describe hybrid scaffolds based on these four cartilage ECM derivatives; we also categorize these scaffolds based on the methods used for their preparation. The use of hybrid scaffolds is increasing in CTE to address the complexity of cartilage tissue. Thus, a comprehensive review on the topic should be a useful guide for future research.Scaffolds fabricated from extracellular matrix (ECM) derivatives are composed of conducive structures for cell attachment, proliferation, and differentiation, but generally do not have proper mechanical properties and load-bearing capacity. In contrast, scaffolds based on synthetic biomaterials demonstrate appropriate mechanical strength, but the absence of desirable biological properties is one of their main disadvantages. To integrate mechanical strength and biological cues, these ECM derivatives can be conjugated with synthetic biomaterials. Hence, hybrid scaffolds comprising both advantages of synthetic polymers and ECM derivatives can be considered a robust vehicle for tissue engineering applications.

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“…Although highly viable 3D cell-laden constructs can be fabricated using low dispensing pressure and larger nozzles, other drawbacks such as decreased structure resolution and printing speed arise. 12–14 To address these shortcomings, many studies have dedicated significant effort to develop the combination of cell-laden hydrogel with woven or non-woven thermoplastic polymers, 15, 16 nano- or microfiber meshes, 17, 18 and inorganic materials. 19, 20 The mechanical properties of composite hydrogels are enhanced and can support cell viability and function from mechanical stress during the regeneration process.…”

Section: Introductionmentioning

confidence: 99%

Enhanced bone tissue regeneration using a 3D printed microstructure incorporated with a hybrid nano hydrogel

et al. 2017

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Three-dimensional (3D) functional constructs with biomimetic mechanical and chemical properties are ideal for various regenerative medicine applications. Within a 3D fabricated construct these properties are intrinsic characteristics of the materials and fabrication method. In this respect, the current use of hydrogels for musculoskeletal tissue repair are not perfect due to the lack of suitable mechanical properties, as well as the high biomimetic requirement for success. To overcome this limitation, we developed a novel functionalized hydrogel with bioactive gold nanoparticles (GNPs) and reinforcing 3D printed microstructure via fused deposition modeling (FDM) for bone tissue regeneration. We used the biodegradable thermoplastic polylactic acid (PLA) as the 3D printed microstructure in combination with photo-curable gelatin hydrogels as the encapsulation matrix for the incorporation of cyclicRGD conjugated GNPs (RGNP), and investigated their mechanical properties. In addition, human adipose-derived stem cells (ADSCs) were encapsulated within the gelatin hydrogel and examined for viability, morphology, and osteogenic differentiation in vitro. The results showed that the stiffness of the composite hydrogel with reinforcing 3D printed microstructure can be readily modulated to simulate the stiffness of the human mandibular condyle. ADSCs encapsulated in the composite structures remained viable within the hydrogel and showed excellent spreading on the 3D printed PLA microstructure. More importantly, osteogenic differentiation with incorporated RGNP promoted significantly higher gene expression of osteogenic specific factors. Therefore, reinforced composite hydrogels are suitable for stem cell differentiation control and bone tissue regeneration.

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Enhancing structural integrity of hydrogels by using highly organised melt electrospun fibre constructs

Cited by 111 publications

References 51 publications

Poly (lactic acid)-based biomaterials for orthopaedic regenerative engineering

Poly (lactic acid)-based biomaterials for orthopaedic regenerative engineering

Reconstruction Strategies of the Ureter and Urinary Diversion Using Tissue Engineering Approaches

Enhanced bone tissue regeneration using a 3D printed microstructure incorporated with a hybrid nano hydrogel

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