Entamoeba histolytica under Oxidative Stress: What Countermeasure Mechanisms Are in Place?

Pineda, Erika; Perdomo, Doranda

doi:10.3390/cells6040044

Cited by 52 publications

(45 citation statements)

References 88 publications

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“…4 Segundo a Global Burden of Disease Study de 2013, as infecções intestinais causadas por protozoário são consideradas a terceira causa de morte a nível mundial, resultando em mais de 100.000 mortes anualmente. 5 Atualmente, pensa-se que estes números estejam sobrestimados em resultado da difícil diferenciação microscópica entre E. histolytica e outros dois parasitas (E. dispar e E. moshkovskii), sendo a E. histolytica a única espécie reconhecida como patógeno humano e a E. dispar dez vezes mais prevalente. 4 A sua distribuição é mundial e é frequentemente diagnosticada em imigrantes e viajantes de áreas endêmicas (nomeadamente Índia, África, México e zonas da América Central e do Sul).…”

Section: Introductionunclassified

“…4 A sua distribuição é mundial e é frequentemente diagnosticada em imigrantes e viajantes de áreas endêmicas (nomeadamente Índia, África, México e zonas da América Central e do Sul). 3,5 Até o ano de 1999, era considerada uma doença de declaração obrigatória em Portugal e os últimos dados publicados (referentes ao período de 1992-1996) reportaram uma taxa de incidência mediana de 0,04 casos/milhão de habitantes. 6 A transmissão dá-se por ingestão de alimentos e água contaminada ou via sexual (fecal-oral).…”

Section: Introductionunclassified

“…6 A transmissão dá-se por ingestão de alimentos e água contaminada ou via sexual (fecal-oral). 3,5 Em países desenvolvidos, onde o risco de transmissão de Entamoeba histolytica por contaminação alimentar é baixo, foi demonstrada uma prevalência de amebíase superior à esperada em homens que fazem sexo La diarrea crónica, caracterizada por la presencia de más de tres heces de consistencia blanda durante al menos cuatro semanas, es frecuentemente encontrada en la práctica clínica. En la diarrea crónica, la probabilidad de una etiología infecciosa es baja, siendo las causas funcionales, inflamatorias, osmóticas o secretoras más comunes.…”

Section: Introductionunclassified

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Entamoeba histolytica como causa de diarreia crônica

Castro¹,

Bacalhau²,

Silva³

et al. 2019

Rev Bras Med Fam Comunidade

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A diarreia crônica, caracterizada pela presença de mais de três dejeções de consistência pastosa durante pelo menos quatro semanas, é frequentemente encontrada na prática clínica. Na diarreia crônica, a probabilidade de uma etiologia infecciosa é baixa, sendo as causas funcionais, inflamatórias, osmóticas ou secretórias mais comuns. A amebíase intestinal é uma causa de diarreia crônica, causada pelo protozoário Entamoeba histolytica, sendo comum e prevalente em países em desenvolvimento. Pode ter várias formas de apresentação, sendo na maioria dos casos assintomática. Apresenta-se o caso clínico de um paciente de 27 anos, sexo masculino, raça caucasiana, homem que pratica sexo com homens (HSH), com diarreia crônica com início há cerca de seis anos. O exame objetivo não revelava alterações. Realizou exame parasitológico de fezes, com isolamento de quistos de Entamoeba histolytica. Foi medicado com metronidazol e paromomicina com resolução clínica do quadro. É importante para o Médico de Família equacionar esta etiologia na investigação de pacientes com diarreia, para um correto e atempado diagnóstico e tratamento, de modo a evitar exames desnecessários, possíveis complicações, a transmissãodo agente e um grave problema de saúde pública.

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Section: Introductionunclassified

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Entamoeba histolytica como causa de diarreia crônica

Castro¹,

Bacalhau²,

Silva³

et al. 2019

Rev Bras Med Fam Comunidade

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“…Lipid and its metabolism apparently play important roles in stage conversion (De Cádiz et al, 2013 ). Furthermore, this anaerobic or microaerophilic parasite has to overcome a wide variety of environmental and host-derived oxidative and nitrosative stresses during its life cycle (Vicente et al, 2009 ; Baumel-Alterzon and Ankri, 2014 ; Pineda and Perdomo, 2017 ). The pathogenic behavior of this parasite depends on their ability to uptake host nutrients through ingestion and degradation of mammalian cells and tissues.…”

Section: Introductionmentioning

confidence: 99%

Non-vesicular Lipid Transport Machinery in Entamoeba histolytica

Das

Nozaki

2018

Front. Cell. Infect. Microbiol.

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Eukaryotic cells are organized into separate membrane-bound compartments that have specialized biochemical signature and function. Maintenance and regulation of distinct identity of each compartment is governed by the uneven distribution and intra-cellular movement of two essential biomolecules, lipids, and proteins. Non-vesicular lipid transport mediated by lipid transfer proteins plays a pivotal role in intra-cellular lipid trafficking and homeostasis whereas vesicular transport plays a central role in protein trafficking. Comparative study of lipid transport machinery in protist helps to better understand the pathogenesis and parasitism, and provides insight into eukaryotic evolution. Amebiasis, which is caused by Entamoeba histolytica, is one of the major enteric infections in humans, resulting in 40–100 thousand deaths annually. This protist has undergone remarkable alterations in the content and function of its sub-cellular compartments as well represented by its unique diversification of mitochondrion-related organelle, mitosome. We conducted domain-based search on AmoebaDB coupled with bioinformatics analyses and identified 22 potential lipid transfer protein homologs in E. histolytica, which are grouped into several sub-classes. Such in silico analyses have demonstrated the existence of well-organized lipid transport machinery in this parasite. We summarized and discussed the conservation and unique features of the whole repertoire of lipid transport proteins in E. histolytica.

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“…Approximately 50 million person in world are affected by E. histolytica and approximately 100,000 person die every year in world [7]. Infection by this parasite is occurs when the host ingests cyst phases in contaminated food or water.…”

Section: Introductionmentioning

confidence: 99%

Study the protective effect of Matricaria chamomilla flower extract against the toxicity of Entamoeba histolytica induces liver and renal dysfunctions in adult albino male rats

Ali¹,

Al-Attar

2018

ijs

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The present study was designed to show the potential role of Matricaria chamomilla flower extract against toxicity of Entamoeba histolytica . The study used 20 adult albino male rats that divide randomly to four groups (each group consist 5 rats); control group received ad libidium, group of rats administrated with 1X10 3 cyct/ml suspension for seven days, group of rats administrated with 1X10 3 cyct/ml suspension and treated with 50mg/kg extract for month, group of rats administrated with 1X10 3 cyct/ml suspension and treated with 100mg/kg extract for month. The results show high significant increased (P < 0.05) in levels of Alanine Aminotransferase (ALT), Aspartate Aminotransferase (AST), Alkaline Phosphatase (ALP), urea, creatinine and uric acid in rats administrated with 1X10 3 cyct/ml suspension. Oxidative stress factor in this group show significant increased (P < 0.05) in levels of MDA (malonedialdehyied) and significant decreased (P < 0.05) in levels of glutathione (GSH) and catalase compared with control group. While, after used M. chamomilla flower extract with Entamoeba histolytica , the results showed non significant changes (P < 0.05) in liver and kidneys function parameters. Also, MDA, GSH and catalase showed non significant changes (P < 0.05) compared with control group. It was concluded that flower extract has been potential role against toxicity of Entamoeba histolytica in adult male albino rats. Science, 2018, Vol. 59, No.2B, pp: 832-838 Keywords IntroductionMatricaria chamomilla (MC) or German chamomile, also spelled chamomile, is one of the most used in medicine field. The plant has been included in the pharmacopoeia of 26 countries [1]. Its found in different countries such as Asia, Australia, North Africa, North and South America [2]. Two species of Matricaria are used in herbalism, Chamaemelum nobile and Matricaria chamomilla [3]. Matricaria chamomilla consist of different types of potential compounds including; terpenoids α-bisabolol, , polysaccharides, essential oils, mineral elements, , fatty acids, flavonoids, and other phenolic [1,4]. Matricaria chamomilla has been different actions in medical line include antibacterial, anti-inflammatory, antifungal, anti-ulcer, antispasmodic, antiviral, and sedative effects [5]. Matricaria chamomilla is used internally mainly as sluggish digestion, for diarrhea and nausea; the urinary tract and for painful menstruation. Externally, may be applied to wounds slow to heal, skin eruptions, infections, such as shingles and boils, throat, hemorrhoids, and eyes [2,6].Infections by Entamoeba histolytica lead to different clinical manifestations and disease, including dysentery, diarrhea, and hepatic liver abscess. Approximately 50 million person in world are affected by E. histolytica and approximately 100,000 person die every year in world [7]. Infection by this parasite is occurs when the host ingests cyst phases in contaminated food or water. After that, trophozoites are released in the small intestine, may colonize the large intestine and ...

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Entamoeba histolytica under Oxidative Stress: What Countermeasure Mechanisms Are in Place?

Cited by 52 publications

References 88 publications

Entamoeba histolytica como causa de diarreia crônica

Entamoeba histolytica como causa de diarreia crônica

Non-vesicular Lipid Transport Machinery in Entamoeba histolytica

Study the protective effect of Matricaria chamomilla flower extract against the toxicity of Entamoeba histolytica induces liver and renal dysfunctions in adult albino male rats

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