Environmental applications of large volume injection in capillary GC using PTV injectors

Mol, Hans; Althuizen, Mariken; Janssen, Hans‐Gerd; Cramers, C.A.M.G.; Brinkman, U.A.Th.

doi:10.1002/jhrc.1240190203

Cited by 64 publications

(24 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…After the splitless transfer step the split valve is opened again to remove solvent vapour and highboiling matrix compounds from the liner. 19 Non-volatile matrix compounds remain deposited in the liner which, if necessary, can be easily exchanged. 20 The LVI (PTV) temperature program started from 458C to 3208C at 308C/s; the transfer column time was 1.5 min, the transfer column flow rate was 3.6 mL/min, and the vent flow rate was 150 mL/min.…”

Section: Large Volume Injection (Lvi) Technique For Gc-c-irmsmentioning

confidence: 99%

Use of a temperature‐programmable injector coupled to gas chromatography–combustion–isotope ratio mass spectrometry for compound‐specific carbon isotopic analysis of polycyclic aromatic hydrocarbons

Mikołajczuk

Geypens

Berglund

et al. 2009

Rapid Comm Mass Spectrometry

View full text Add to dashboard Cite

Compound-specific isotopic analysis (CSIA) can provide information about the origin of analysed compounds; for instance, polycyclic aromatic hydrocarbons (PAHs) in aerosols. This could be a valuable tool in source apportionment of particulate matter (PM) air pollution. Because gas chromatography-combustion-isotope ratio mass spectrometry (GC-C-IRMS) analysis requires an amount of at least 10 ng of an individual PAH, a high concentration of PAHs in the injected extract is needed. When the concentration is low a large volume injector creates the possibility of introducing a satisfactory amount of individual PAHs. In this study a temperature-programmable injector was coupled to GC-C-IRMS and injection parameters (solvent level, transfer column flow, transfers time) were optimised using six solid aromatic compounds (anthracene, fluoranthene, pyrene, benzo[b]fluoranthene, benzo[k]fluoranthene, benzo[a]pyrene) dissolved in n-pentane and EPA 610 reference mixture. CSIA results for solid PAHs were compared with results obtained for the single components analysed by elemental analysis-isotope ratio mass spectrometry. The injection method was validated for two sample injection volumes, 50 and 100 microL. This method was also compared with commonly used splitless injection. To be included in the study, measurements had to have an uncertainty lower than 0.5 per thousand for delta(VPDB)13C and a minimum peak height of 200 mV. The lower concentration limits at which these criteria were fulfilled for PAHs were 30 mg/L for 1 microL in splitless injection and 0.3 and 0.2 mg/L for 50 and 100 microL, respectively, in large volume injection.

show abstract

Section: Large Volume Injection (Lvi) Technique For Gc-c-irmsmentioning

confidence: 99%

Use of a temperature‐programmable injector coupled to gas chromatography–combustion–isotope ratio mass spectrometry for compound‐specific carbon isotopic analysis of polycyclic aromatic hydrocarbons

Mikołajczuk

Geypens

Berglund

et al. 2009

Rapid Comm Mass Spectrometry

View full text Add to dashboard Cite

show abstract

“…The use of standards in blank extracts (matrixstandard calibrations) is the option followed by many investigators and routine laboratories due to the ease of use and effectiveness of the approach to avoid false quantitation [16,17,18,19,20,21,22]. However, due to the existence of matrix and pesticide-dependence [23] a matrixstandard calibration curve should be built for each different vegetable, which is unpractical.…”

Section: Introductionmentioning

confidence: 99%

“…So, of the total number of analyses carried out in the last two years (16,000) in the laboratory CUAM (Almería, Spain), credited by the norms ISO 17025, 22.5% of the pesticides detected were pyrethroids. This fact shows the necessity of developing methods for the determination of pyrethroid residues, which can be applied to different commodities.…”

Section: Introductionmentioning

confidence: 99%

A comparative study of the correction of systematic errors in the quantitation of pyrethroids in vegetables using calibration curves prepared using standards in pure solvent

Martínez-Galera

López-López²,

Gil-García

et al. 2003

Anal Bioanal Chem

View full text Add to dashboard Cite

A comparative study of two mathematical approaches was performed in order to correct systematic errors due to the presence of the unexpected interferences which appear when the quantitation of the analyte in real samples is carried out with calibration curves built using standards in pure solvent. These methods consisted in the establishment of different mathematical expressions which transform the concentration (Cs) obtained using calibration graphs built using pure solvent into the corrected concentration (C(M)) that should be obtained if the quantitation is carried out with calibration curves built using standards dissolved in blank matrix extracts. In the two approaches the correction is performed from the results of an intermediate precision study which was carried out using both calibration graphs (prepared using pure solvent and blank matrix extract). By using ANCOVA to compare the slope of both solvent-based and matrix-matched calibration graphs, matrix effect was found in the determination of deltamethrin in tomato and acrinathrin in tomato and pepper. In these cases, both approaches led to good results.

show abstract

“…Researchers have developed several LVI techniques for GC, which include on-column injection [15], loop-type injection [14,16], and programmed-temperature vaporization injection (PTV) [17][18][19][20]. The reported automated online SPE/GC and GC/MS included mobile rack systems based on x-y-z robotic techniques using switching valves and disposable small SPE cartridges [21,22], liquid chromatography-like systems using high pressure liquid pumps and switching valves as well as reusable SPE pre-columns or cartridges [23,24], and mobile rack systems based on x-y-z robotic techniques using syringes and disposable 96-well extraction plates [25].…”

Section: Introductionmentioning

confidence: 99%

Determination of selected semi-volatile organic compounds in water using automated online solid-phase extraction with large-volume injection/gas chromatography/mass spectrometry

McCarty

George

2011

Front. Environ. Sci. Eng. China

View full text Add to dashboard Cite

A rapid, sensitive, and cost-effective analytical method was developed for the analysis of selected semivolatile organic compounds in water. The method used an automated online solid-phase extraction technique coupled with programmed-temperature vaporization large-volume injection gas chromatography/mass spectrometry. The water samples were extracted by using a fully automated mobile rack system based on x-y-z robotic techniques using syringes and disposable 96-well extraction plates. The method was validated for the analysis of 30 semivolatile analytes in drinking water, groundwater, and surface water. For a sample volume of 10 mL, the linear calibrations ranged from 0.01 or 0.05 to 2.5 μg$L -1 , and the method detection limits were less than 0.1 μg$L -1 . For the reagent water samples fortified at 1.0 μg$L -1 and 2.0 μg$L -1 , the obtained mean absolute recoveries were 70%-130% with relative standard deviations of less than 20% for most analytes. For the drinking water, groundwater, and surface water samples fortified at 1.0 μg$L -1 , the obtained mean absolute recoveries were 50%-130% with relative standard deviations of less than 20% for most analytes. The new method demonstrated three advantages: 1) no manipulation except the fortification of surrogate standards prior to extraction; 2) significant cost reduction associated with sample collection, shipping, storage, and preparation; and 3) reduced exposure to hazardous solvents and other chemicals. As a result, this new automated method can be used as an effective approach for screening and/or compliance monitoring of selected semi-volatile organic compounds in water.

show abstract

Environmental applications of large volume injection in capillary GC using PTV injectors

Cited by 64 publications

References 27 publications

Use of a temperature‐programmable injector coupled to gas chromatography–combustion–isotope ratio mass spectrometry for compound‐specific carbon isotopic analysis of polycyclic aromatic hydrocarbons

Use of a temperature‐programmable injector coupled to gas chromatography–combustion–isotope ratio mass spectrometry for compound‐specific carbon isotopic analysis of polycyclic aromatic hydrocarbons

A comparative study of the correction of systematic errors in the quantitation of pyrethroids in vegetables using calibration curves prepared using standards in pure solvent

Determination of selected semi-volatile organic compounds in water using automated online solid-phase extraction with large-volume injection/gas chromatography/mass spectrometry

Contact Info

Product

Resources

About