Environmental Epigenetics and Asthma

Miller, Rachel L.; Ho, Shuk‐Mei

doi:10.1164/rccm.200710-1511pp

Cited by 258 publications

(93 citation statements)

References 94 publications

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“…However, significant heterogeneity of asthma phenotypes exist across individuals, and currently comprise five different subtypes characterized by age of onset, presence of T helper type 2 cell (T H 2) inflammation, involvement of eosinophilia, obesity level and whether the attack is exercise-induced (Wenzel 2012). Both genetic and environmental factors are associated with asthma development and exacerbation, though an interaction between the two most likely contributes to disease severity and responsiveness (Martinez, 2006;Miller and Ho, 2008). In contrast to CF, IPF and COPD, asthma has a relatively low fatality rate and can be appropriately managed for most patients with inhaled glucocorticoids.…”

Section: Asthmamentioning

confidence: 99%

The role of microRNAs in chronic respiratory disease: recent insights

Stolzenburg¹,

Harris²

2017

Biological Chemistry

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Chronic respiratory diseases encompass a group of diverse conditions affecting the airways, which all impair lung function over time. They include cystic fibrosis (CF), idiopathic pulmonary fibrosis (IPF), chronic obstructive pulmonary disease (COPD) and asthma, which together affect hundreds of millions of people worldwide. MicroRNAs (miRNAs), a class of small non-coding RNAs involved in post-transcriptional gene repression, are now recognized as major regulators in the development and progression of chronic lung disease. Alterations in miRNA abundance occur in lung tissue, inflammatory cells, and freely circulating in blood and are thought to function both as drivers and modifiers of disease. Their importance in lung pathology has prompted the development of miRNA-based therapies and biomarker tools. Here, we review the current literature on miRNA expression and function in chronic respiratory disease and highlight further research that is needed to propel miRNA treatments for lung disorders towards the clinic.

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Section: Asthmamentioning

confidence: 99%

The role of microRNAs in chronic respiratory disease: recent insights

Stolzenburg¹,

Harris²

2017

Biological Chemistry

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“…Previous studies have suggested that epigenetic regulation may partially regulate genes and cause asthma in response to exposure to environmental factors [5,6]. Yang et al [7] indicated that the hypermethylation of CpG sites in the ADAM33 promoter resulted in a loss of ADAM33 expression in bronchial epithelial cells.…”

Section: Introductionmentioning

confidence: 99%

The Methylation Patterns of a Disintegrin and Metalloproteinase 33 Gene (ADAM33) in Adult Asthma

Yang

Li²,

Huang³

et al. 2012

Int Arch Allergy Immunol

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Background: Asthma is a common chronic inflammatory respiratory disease. Previous studies have suggested that the pathogenesis of asthma may be affected by epigenetic regulation. The purpose of this study is to characterize the effect of the methylation of each CpG site in the ADAM33 (a disintegrin and metalloproteinase 33) gene in adult asthma. Methods: A human CpG island microarray was used to examine 4 asthmatic cases and 4 healthy controls, and the results suggested that there might be differences in methylation within exon 9 of the ADAM33 gene. Therefore, we designed a case-control study with 50 asthmatic patients and 50 age- and sex-matched healthy controls to examine the relationship between the CpG methylation of the ADAM33 gene and asthma using bisulfite deoxyribonucleic acid modification and sequencing. Results: Bisulfite sequencing experiments showed that the 14 CpG sites in exon 9 of the ADAM33 gene were highly methylated (100%) in all individuals. The proportions of methylation of the 14 CpG sites in ADAM33 in the case group were not different from those of the control group. The methylation of exon 9 of this locus was not associated with age, sex, IgE levels, or lung function. This study found no association between the methylation of CpG sites in exon 9 of the ADAM33 gene and adult asthma. Conclusions: The 14 CpG sites were highly methylated in the case and control groups. Further investigation of exon 9 in ADAM33 in a larger population is needed to evaluate its role in asthma.

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“…Amongst those discussed in the literature (online suppl. table 1) are obesity, diabetes type 2 [45,46,47,48,49], allergies [50,51], asthma [52,53,54,55], behavioral disorders (such as schizophrenia) [56,57,58], attention-deficit hyperactivity disorder [59], diseases of the eye [60], Crohn's disease [54], leukaemia [61], Parkinson's disease [62], inflammatory bowel disease [63], and post-traumatic stress disorder [64], along with many other diseases of varying severity [29], including imprinting disorders: Prader-Willi, Angelman, Beckwith-Wiedemann, and Silver-Russell syndromes [65]. …”

Section: Resultsmentioning

confidence: 99%

“…table 1). The most commonly acknowledged environmental factors are diet, lifestyle behaviors (such as smoking or alcohol consumption) and exposure to pathogens or pollutants [52,54,55,67,68,69]. Exposure to toxicants such as arsenic, benzene and nickel are also discussed in the literature along with numerous examples of endocrine disruptors [61,70,71].…”

Section: Resultsmentioning

confidence: 99%

Equity in Public Health: An Epigenetic Perspective

Stapleton¹,

Schröder‐Bäck²,

Townend

2013

Public Health Genomics

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Evidence emerging from the study of epigenetics and epigenomics challenges notions of health by enhancing understanding of disease etiologies and improving awareness of new health risks. New paradigms arising from epigenetic and epigenomic research present challenging cases through which to debate theories of justice in health because they expand the concept of health and, controversially, place value on what was previously assumed to be ‘healthy' individual variance. Discoveries of the dynamic nature of the epigenome and its variable sensitivity towards change in numerous phenomena add further complexity to the assessment of health inequalities. Such evidence can cast doubt on perceptions of justice in health, which in turn raises questions over the suitability of actions taken in pursuit of equity. This article discusses how recent developments in epigenetics and epigenomics may impact upon assessments of equity in health. A review of literature discussing possible health risks associated with acquired yet heritable epigenetic variance is used to highlight the diversity of possible pathways through which health may be influenced. From this context, the consideration of health risk with respect to epigenetics, it is argued, demands a more inclusive concept of health when used in discussions of inequities.

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Environmental Epigenetics and Asthma

Cited by 258 publications

References 94 publications

The role of microRNAs in chronic respiratory disease: recent insights

The role of microRNAs in chronic respiratory disease: recent insights

The Methylation Patterns of a Disintegrin and Metalloproteinase 33 Gene (ADAM33) in Adult Asthma

Equity in Public Health: An Epigenetic Perspective

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