Environmental epigenetics and epigenetic inheritance in domestic farm animals

Thompson, Ryan P.; Nilsson, Eric; Skinner, Michael K.

doi:10.1016/j.anireprosci.2020.106316

Cited by 50 publications

(28 citation statements)

References 87 publications

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“…Using the ALSPAC cohort, paternal early age cigarette smoking was shown to significantly increased body mass in adult children, which was stronger for male offspring [31]. There is evidence for transgenerational effects in domesticated farm animals and birds from parental exposures to environmental toxicants, nutrients and infectious agents [55,56].…”

Section: Mechanisms For Increased Mental Health Disorders In Childrenmentioning

confidence: 99%

An epigenetic, transgenerational model of increased mental health disorders in children, adolescents and young adults

Monaco

2020

Eur J Hum Genet

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Prevalence rates of mental health disorders in children and adolescents have increased two to threefold from the 1990s to 2016. Some increase in prevalence may stem from changing environmental conditions in the current generation which interact with genes and inherited genetic variants. Current measured genetic variant effects do not explain fully the familial clustering and high heritability estimates in the population. Another model considers environmental conditions shifting in the previous generation, which altered brain circuits epigenetically and were transmitted to offspring via non-DNA-based mechanisms (intergenerational and transgenerational effects). Parental substance use, poor diet and obesity are environmental factors with known epigenetic intergenerational and transgenerational effects, that regulate set points in brain pathways integrating sensory-motor, reward and feeding behaviors. Using summary statistics for eleven neuropsychiatric and three metabolic disorders from 128,989 families, an epigenetic effect explains more of the estimated heritability when a portion of parental environmental effects are transmitted to offspring alongside additive genetic variance.

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Section: Mechanisms For Increased Mental Health Disorders In Childrenmentioning

confidence: 99%

An epigenetic, transgenerational model of increased mental health disorders in children, adolescents and young adults

Monaco

2020

Eur J Hum Genet

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“…For example, DNA methylation at promoter regions can affect the binding of transcription factors, small non-coding RNAs can also regulate the transcription and translation in different ways, histone modification and chromatin states can determine the accessibility of chromatin for gene expression. Epigenetic regulation of multiple traits of dairy cow under different environments have been studied broadly and deeply ( Singh et al, 2010 ; Ibeagha-Awemu and Zhao, 2015 ; Thompson et al, 2020 ). However, direct study of involvement of epigenetic factors in G × E interactions is still missing.…”

Section: Genotype × Environment Interactionmentioning

confidence: 99%

Parental Effects on Epigenetic Programming in Gametes and Embryos of Dairy Cows

Sirard

2020

Front. Genet.

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The bovine represents an important agriculture species and dairy breeds have experienced intense genetic selection over the last decades. The selection of breeders focused initially on milk production, but now includes feed efficiency, health, and fertility, although these traits show lower heritability. The non-genetic paternal and maternal effects on the next generation represent a new research topic that is part of epigenetics. The evidence for embryo programming from both parents is increasing. Both oocytes and spermatozoa carry methylation marks, histones modifications, small RNAs, and chromatin state variations. These epigenetic modifications may remain active in the early zygote and influence the embryonic period and beyond. In this paper, we review parental non-genetic effects retained in gametes on early embryo development of dairy cows, with emphasis on parental age (around puberty), the metabolism of the mother at the time of conception and in vitro culture (IVC) conditions. In our recent findings, transcriptomic signatures and DNA methylation patterns of blastocysts and gametes originating from various parental and IVC conditions revealed surprisingly similar results. Embryos from all these experiments displayed a metabolic signature that could be described as an “economy” mode where protein synthesis is reduced, mitochondria are considered less functional. In the absence of any significant phenotype, these results indicated a possible similar adaptation of the embryo to younger parental age, post-partum metabolic status and IVC conditions mediated by epigenetic factors.

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“…The response to an external stimulus term comprises any mechanism that regulates or modifies the gene expression or secretion or enzyme production as a result of an external stimulus (e.g., nutritional, environmental, maternal behavior) or epigenomics [64]. In livestock, various studies investigated the molecular epigenetic mechanisms that regulate the expression of certain genes potentially involved in reproductive traits' expression, sometimes as a response to an external stimulus [65][66][67][68]. It is important to highlight that multiple external factors can leave epigenetic marks that could affect further generations and may be related to the activity and levels of AMH and AFP.…”

Section: Discussionmentioning

confidence: 99%

Genetic Parameters and Genome-Wide Association Studies for Anti-Müllerian Hormone Levels and Antral Follicle Populations Measured After Estrus Synchronization in Nellore Cattle

Grigoletto

Santana

Bressan

et al. 2020

Animals

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Reproductive efficiency plays a major role in the long-term sustainability of livestock industries and can be improved through genetic and genomic selection. This study aimed to estimate genetic parameters (heritability and genetic correlation) and identify genomic regions and candidate genes associated with anti-Müllerian hormone levels (AMH) and antral follicle populations measured after estrous synchronization (AFP) in Nellore cattle. The datasets included phenotypic records for 1099 and 289 Nellore females for AFP and AMH, respectively, high-density single nucleotide polymorphism (SNP) genotypes for 944 animals, and 4129 individuals in the pedigree. The heritability estimates for AMH and AFP were 0.28 ± 0.07 and 0.30 ± 0.09, and the traits were highly and positively genetically correlated (rG = 0.81 ± 0.02). These findings indicated that these traits can be improved through selective breeding, and substantial indirect genetic gains are expected by selecting for only one of the two traits. A total of 31 genomic regions were shown to be associated with AMH or AFP, and two genomic regions located on BTA1 (64.9–65.0 Mb and 109.1–109.2 Mb) overlapped between the traits. Various candidate genes were identified to be potentially linked to important biological processes such as ovulation, tissue remodeling, and the immune system. Our findings support the use of AMH and AFP as indicator traits to genetically improve fertility rates in Nellore cattle and identify better oocyte donors.

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Environmental epigenetics and epigenetic inheritance in domestic farm animals

Cited by 50 publications

References 87 publications

An epigenetic, transgenerational model of increased mental health disorders in children, adolescents and young adults

An epigenetic, transgenerational model of increased mental health disorders in children, adolescents and young adults

Parental Effects on Epigenetic Programming in Gametes and Embryos of Dairy Cows

Genetic Parameters and Genome-Wide Association Studies for Anti-Müllerian Hormone Levels and Antral Follicle Populations Measured After Estrus Synchronization in Nellore Cattle

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