Environmental non-occupational risk factors associated with bladder cancer

Ferrís, J; Berbel, O.; Alonso-López, J.; García, Javier de Santiago; Ortega, J.A.

doi:10.1016/j.acuroe.2013.02.008

Cited by 13 publications

(6 citation statements)

References 38 publications

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“…Limitations cited by the authors of the meta-analysis were the heterogeneity with which smoking histories were obtained and the cutpoints used for stratifying smoking intensities and durations. This is important, as there is strong evidence that smoking duration and intensity are positively correlated with an increased risk of BC [18][19][20][21].…”

Section: Smokingmentioning

confidence: 99%

Epidemiology of Bladder Cancer: A Systematic Review and Contemporary Update of Risk Factors in 2018

et al. 2018

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Context: Bladder cancer (BC) is a significant health problem, and understanding the risk factors for this disease could improve prevention and early detection. Objective:To provide a systematic review and summary of novel developments in epidemiology and risk factors for BC. Evidence acquisition:A systematic review of original articles was performed by two pairs of reviewers (M.G.C., I.J., F.E., and K.P.) using PubMed/Medline in December 2017, updated in April 2018. To address our primary objective of reporting contemporary studies, we restricted our search to include studies from the last 5 yr. We subdivided our review according to specific risk factors (PICO [Population Intervention Comparator Outcome]). Evidence synthesis:Our search found 2191 articles, of which 279 full-text manuscripts were included. We separated our manuscripts by the specific risk factor they addressed (PICO). According to GLOBOCAN estimates, there were 430 000 new BC cases and 165 000 deaths worldwide in 2012. Tobacco smoking and occupational exposure to carcinogens remain the factors with the highest attributable risk. The literature was limited by heterogeneity of data. Conclusions:Evidence is emerging regarding gene-environment interactions, particularly for tobacco and occupational exposures. In some populations, incidence rates are declining, which may reflect a decrease in smoking.Standardisation of reporting may help improve epidemiologic evaluation of risk. Patient summary:Bladder cancer is common worldwide, and the main risk factors are tobacco smoking and exposure to certain chemicals in the working and general environments. There is ongoing research to identify and reduce risk factors, as well as to understand the impact of genetics on bladder cancer risk.

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Section: Smokingmentioning

confidence: 99%

Epidemiology of Bladder Cancer: A Systematic Review and Contemporary Update of Risk Factors in 2018

et al. 2018

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“…In China, bladder cancer is more prevalent than other urinary tract cancers and is one of the most common malignancies, accounting for 3.2% of all cancers. There are many risk factors involved in the formation of bladder tumours , including exposure to arylamines, smoking, low fluid intake, chronic urinary infection due to Schistosomal haematobium infection, low N‐acetyltransferase activity and the frequent use of hair dye. More than 90% of bladder cancers are transitional cell carcinomas (TCCs).…”

Section: Introductionmentioning

confidence: 99%

Targeted inhibition of Polo‐like kinase 1 by a novel small‐molecule inhibitor induces mitotic catastrophe and apoptosis in human bladder cancer cells

Zhang

Kong

2016

J Cellular Molecular Medi

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Bladder cancer is a common cancer with particularly high recurrence after transurethral resection. Despite improvements in neoadjuvant chemotherapy, the outcome of patients with advanced bladder cancer has changed very little. In this study, the anti‐tumour activities of a novel Polo‐like kinase 1 (PLK1) inhibitor (RO3280) was evaluated in vitro and in vivo in the bladder carcinoma cell lines 5637 and T24. MTT assays, colony‐formation assays, flow cytometry, cell morphological analysis and trypan blue exclusion assays were used to examine the proliferation, cell cycle distribution and apoptosis of bladder carcinoma cells with or without RO3280 treatment. Moreover, real‐time RT‐PCR and Western blotting were used to detect the expressions of genes that are related to these cellular processes. Our results showed that RO3280 inhibited cell growth and cell cycle progression, increased Wee1 expression and cell division cycle protein 2 phosphorylation. In addition, RO3280 induced mitotic catastrophe and apoptosis, increased cleaved PARP (poly ADP‐ribose polymerase) and caspase‐3, and decreased BubR1 expression. The in vivo assay revealed that RO3280 retarded bladder cancer xenograft growth in a nude mouse model. Although further laboratory and pre‐clinical investigations are needed to corroborate these data, our demonstration of bladder cancer growth inhibition and dissemination using a pharmacological inhibitor of PLK1 provides new opportunities for future therapeutic intervention.

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“…Hossein Keymoosi 1 , Elmira Gheytanchi 2 , Mojgan Asgari 1,2,3 , Ahmad Shariftabrizi 4 , Zahra Madjd 1,2,5 * chronic cystitis (Salehi et al, 2011;Ahmad et al, 2012;Ferris et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

ALDH1 in Combination with CD44 as Putative Cancer Stem Cell Markers are Correlated with Poor Prognosis in Urothelial Carcinoma of the Urinary Bladder

Keymoosi¹,

Gheytanchi²,

Asgari³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Environmental non-occupational risk factors associated with bladder cancer

Cited by 13 publications

References 38 publications

Epidemiology of Bladder Cancer: A Systematic Review and Contemporary Update of Risk Factors in 2018

Epidemiology of Bladder Cancer: A Systematic Review and Contemporary Update of Risk Factors in 2018

Targeted inhibition of Polo‐like kinase 1 by a novel small‐molecule inhibitor induces mitotic catastrophe and apoptosis in human bladder cancer cells

ALDH1 in Combination with CD44 as Putative Cancer Stem Cell Markers are Correlated with Poor Prognosis in Urothelial Carcinoma of the Urinary Bladder

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