Enzymatic Profile of Gingival Crevicular Fluid in Association With Periodontal Status

Koss, Myriam A.; Castro, Cecilia E.; Salúm, Karina M.; López, Marı́a Elena

doi:10.1309/lmcnuqi8ulcuk2bk

Cited by 12 publications

(8 citation statements)

References 22 publications

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“…In the present study, LDH in patients with localized aggressive periodontitis was higher than in patients with generalized aggressive periodontitis, and both forms of aggressive periodontitis had higher values in the severe group than in the moderate and control groups. Our conclusion, based on previous work, is that LDH increases when cell death begins, reaches a maximum after some time, and then begins to decline (24).…”

Section: Discussionsupporting

confidence: 59%

“…In our previously published study, in patients with chronic periodontitis, the chemical determination of AST in gingival crevicular fluid of periodontally healthy control subjects and patients with different states of periodontal disease showed a substantial relationship between AST levels and the clinical indices, demonstrating that only patients with more severe periodontitis had higher AST levels (24). This enzyme showed significant differences when the moderate and severe groups were compared with the control group, suggesting that it could be used to determine stages in generalized aggressive periodontitis (26–28).…”

Section: Discussionmentioning

confidence: 93%

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Intracytoplasmic enzymes in gingival crevicular fluid of patients with aggressive periodontitis

Castro¹,

Koss

López

2011

Journal of Periodontal Research

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Section: Discussionsupporting

confidence: 59%

Section: Discussionmentioning

confidence: 93%

Intracytoplasmic enzymes in gingival crevicular fluid of patients with aggressive periodontitis

Castro¹,

Koss

López

2011

Journal of Periodontal Research

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“…[22] Hence accurate detection of periodontal sites exhibiting disease progression or those at risk of future deterioration has always proven difficult. [23] Traditional diagnostic procedures are inherently limited, in that only disease history, not current disease status, can be assessed. These conventional disease diagnosis techniques lack the capacity to identify highly susceptible patients who are at risk for future breakdown.…”

Section: Discussion:-mentioning

confidence: 99%

Beta Glucuronidase Activity in Diabetes Associated Periodontitis

Gawali¹,

Padhye²,

Chavan³

2020

IJAR

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Diabetes mellitus is a risk factor for development of periodontal disease with progressive periodontal destruction seen in diabetic patients. Advances in oral and periodontal disease diagnostic research are moving towards methods whereby periodontal risk can be identified and quantified by objective measures such as biomarkers. The aim of this study was to identify the presence of beta glucuronidase activity as an enzymatic biomarker of periodontal tissue destruction in patients of Diabetes mellitus associated with Periodontitis. β Glucuronidase activitywas estimated in saliva, GCF (Gingival Crevicular Fluid) and serum in healthy subjects and patients with Diabetes mellitus, Periodontitis and Diabetes associated periodontitis. Enzyme activity was compared with clinical parameters like Probing pocket depth, Plaque Index and Gingival Index. It was maximally raised in diabetic cases with periodontitis. Enzyme activity was found to be highest in crevicular fluid compared to saliva and serum. However, serum Glucuronidase correlated significantly with clinical indices. β-glucuronidase may be employed on routine basis as a chair side test for screening and diagnosis of patients with periodontitis in diabetics.

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“…The patients treated with DOX gel were administered 115 mg gel containing 10 mg of DOX and the GCF samples were taken 7 days after the local treatment. GCF from the selected periodontal pockets was collected using the method proposed by Koss et al In brief, the paper strips were placed in selected periodontal pockets until mild resistance was felt and left in place for 30 s (Koss et al, 2009).…”

Section: Methodsmentioning

confidence: 99%

Chemometric evaluation of the efficacy of locally administered chlorhexidine in patients with periodontal disease

Bogdanovska

Panovska

Поповска

et al. 2017

Saudi Pharmaceutical Journal

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The process of assessment of drug efficacy produces multivariate data which are difficult to interpret. The interpretation and extraction of relevant data requires application of chemometric algorithms for multivariate data analysis. The aim of our study was evaluation of the efficacy of local treatment with chlorhexidine (CHX) in patients suffering from periodontal disease by chemometric algorithms for multivariate data analysis. Several algorithms were used: principal component analysis (PCA), partial least squares discriminant analysis (PLS-DA) and orthogonal projection to latent structures discriminant analysis (OPLS-DA). The PCA models identified the examined variables as suitable for monitoring the periodontal disease progression at the same time revealing mutual relationship among them. The developed PLS-DA model successfully distinguished patients treated with CHX from non-treated patients. The OPLS-DA model revealed differences in the mechanism of action of the two widely applied treatments in periodontal disease, local administration of CHX and local administration of doxycycline (DOX). The approach presented in this study opens the possibility of application of chemometric algorithms for multivariate data analysis for assessment of treatment efficacy.

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Enzymatic Profile of Gingival Crevicular Fluid in Association With Periodontal Status

Cited by 12 publications

References 22 publications

Intracytoplasmic enzymes in gingival crevicular fluid of patients with aggressive periodontitis

Intracytoplasmic enzymes in gingival crevicular fluid of patients with aggressive periodontitis

Beta Glucuronidase Activity in Diabetes Associated Periodontitis

Chemometric evaluation of the efficacy of locally administered chlorhexidine in patients with periodontal disease

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