Enzymatic studies of cisplatin induced oxidative stress in hepatic tissue of rats

Pratibha, R.; Sameer, R.; Rataboli, Padmanabh V.; Bhiwgade, Dayanand A.; Dhume, Chitra Y.

doi:10.1016/j.ejphar.2006.01.007

Cited by 145 publications

(104 citation statements)

References 19 publications

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“…Therefore, the depletion of GSH is an early and necessary event occurring during cisplatin-induced lipid peroxidation and subsequent toxicity. It has been suggested that the levels of GSH in the liver are significantly reduced by cisplatin treatment, although very little information is currently available regarding cisplatin-induced liver injury and the mechanisms underlying its hepatotoxicity (42,43), and this suggestion was corroborated in our repeated preliminary experiments (data not shown). In the present study, our results showed that the repeated oral administration of ISL in combination with cisplatin treatment prevented cisplatin-mediated increases in the levels of serum nitric oxide and tissue lipid peroxidation, and also recovered the depleted GSH levels in tissue to a significant degree.…”

Section: Discussionsupporting

confidence: 76%

Isoliquiritigenin Inhibits Tumor Growth and Protects the Kidney and Liver Against Chemotherapy-Induced Toxicity in a Mouse Xenograft Model of Colon Carcinoma

et al. 2008

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Abstract. A growing amount of attention has been focused on the investigation of the effects of chemopreventive agents on the inhibition of cancer cell growth and toxicity in combination with chemotherapeutics. The objective of this study was to determine whether isoliquiritigenin (ISL) has the potential to serve as a beneficial supplement during cisplatin chemotherapy. We found that the administration of ISL alone significantly reduced the size of the solid tumors in CT-26 cell-inoculated BALB / c mice, without any detectable induction of nephrotoxicity, hepatotoxicity, and oxidative stress, and ISL reduced the viability and DNA synthesis of CT-26 murine colon cancer cells in a dose-dependent manner. ISL did not affect the therapeutic efficacy of cisplatin. Furthermore, ISL suppressed cisplatin-induced kidney damage characterized by increases in serum creatinine and blood urea nitrogen, as well as cisplatin-induced liver damage characterized by increases in serum alanine aminotransferase and aspartate aminotransferase. The repeated oral administration of ISL prior to cisplatin treatment exerted a preventive effect on cisplatin-mediated increases in serum nitric oxide and tissue lipid peroxidation levels, and it recovered depleted GSH levels in the tissues. Therefore, supplementation with ISL may be an effective approach to counteracting the side effects of cisplatin therapy in cancer patients.

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Section: Discussionsupporting

confidence: 76%

Isoliquiritigenin Inhibits Tumor Growth and Protects the Kidney and Liver Against Chemotherapy-Induced Toxicity in a Mouse Xenograft Model of Colon Carcinoma

et al. 2008

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“…It has been proposed that oxidative stress exists in the early stage of cisplatin-induced nephrotoxicity and also in hepatotoxicity (Iraz et al, 2006;Mansour et al, 2006;Pratibha et al, 2006;Satoh et al, 2000). In rats, mitochondrial dysfunction in kidney and liver was evidenced after cisplatin treatment.…”

Section: Cellular Response To Cisplatin and Oxidative Stressmentioning

confidence: 95%

The Yeast Genes ROX1, IXR1, SKY1 and Their Effect upon Enzymatic Activities Related to Oxidative Stress

Leiro¹,

Lombardero²,

Vázquez³

et al. 2012

Oxidative Stress - Molecular Mechanisms and Biological Effects

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“…Cisplatin in the present study produced significant reduction of the activities of plasma catalase (an antioxidant enzyme), plasma total antioxidant capacity accompanied by increased lipid peroxidation compared with the control rats. The renal oxidative stress may have resulted from the build-up of ROS such as O 2 -and H 2 O 2 following the decrease in the activities of the renal antioxidant enzymes, which is typical during cisplatin treatment [Pratibha et al, 2006]. The increased generation of O 2 -and H 2 O 2 leads to increased production of the more reactive hydroxyl (OH -) radical via Fenton and Haber-Weiss reactions [Stadtman, 1990].…”

Section: Discussionmentioning

confidence: 99%

Plant Food Extracts as Source of Bioactive Compounds for Prevention of Cisplatin-Induced Kidney Dysfunction in Rats

Al‐Okbi¹,

Mohamed²,

Hamed³

et al. 2014

Pol. J. Food Nutr. Sci.

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The present study investigated the protective effect of extracts prepared from grape, coriander, roselle and fennel in a rat model of kidney dysfunction induced by intraperitoneal cisplatin. A mixture of ethanol and petroleum ether extracts was prepared from a given plant. Six groups of rats were analyzed; control healthy, cisplatin group and 4 test groups where rats were given a daily oral dose of each extract mixture before cisplatin injection. Different biochemical and cytogenetic parameters and kidney histopathology were determined. Total phenolic contents, fatty acids and unsaponifiable matter (UNSAP) were assessed in the extracts. Results showed roselle ethanol extract to have the highest phenolic content (15.584 g GAE/100 g extract). Fatty acid analysis revealed the presence of linoleic and linolenic acid in all studied plants. Coriander oil showed the highest content of unsaturated fatty acids (85%). GLC investigation of the UNSAP showed the presence of campesterol in all the studied plants. Grape oil contained the highest content of phytosterol (15.9%). Cisplatin treatment induced significant increase in plasma urea, creatinine and malondialdehyde along with significant reduction in plasma albumin, total protein, catalase activity and total antioxidant level as well as reduction in creatinine clearance compared to normal control. Histopathological examination proved the induction of kidney dysfunction by cisplatin. Chromosomal aberration and sperm-shape abnormalities were noticed after cisplatin treatment. Administration of extract mixtures produced improvements in biochemical, histopathological and cytogenetic parameters. Extracts mixture under study offered protection from cisplatin induced kidney dysfunction via antioxidant and possibly anti-inflammatory actions.

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Enzymatic studies of cisplatin induced oxidative stress in hepatic tissue of rats

Cited by 145 publications

References 19 publications

Isoliquiritigenin Inhibits Tumor Growth and Protects the Kidney and Liver Against Chemotherapy-Induced Toxicity in a Mouse Xenograft Model of Colon Carcinoma

Isoliquiritigenin Inhibits Tumor Growth and Protects the Kidney and Liver Against Chemotherapy-Induced Toxicity in a Mouse Xenograft Model of Colon Carcinoma

The Yeast Genes ROX1, IXR1, SKY1 and Their Effect upon Enzymatic Activities Related to Oxidative Stress

Plant Food Extracts as Source of Bioactive Compounds for Prevention of Cisplatin-Induced Kidney Dysfunction in Rats

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