Enzyme and pH-responsive nanovehicles for intracellular drug release and photodynamic therapy

Zhang, Ting; Huang, Shiying; Lin, Huiming; An, Na; Tong, Ruihan; Chen, Yuhua; Wang, Ying; Qu, Fengyu

doi:10.1039/c6nj02357f

Cited by 22 publications

(10 citation statements)

References 40 publications

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“…Nanoparticles can be modified with specific enzyme-labile linkages to trigger drug release and control the initial response time of the system. Sensitive peptide gatekeepers, i.e., succinic acid-glycinephenylalanine-leucine-glycine (SGFLG) sequence and transferrin were grafted onto MSN surfaces to encapsulate an anticancer drug (DOX) and photosensitizer (chlorine e6), as shown in Figure 14 [141]. Sensitive polypeptide gatekeepers induce gate opening and controlled drug release towards their degradation in a cathepsin D (protease) and low pH environment.…”

Section: Enzyme-responsive Gatesmentioning

confidence: 99%

Smart gating porous particles as new carriers for drug delivery

Thananukul

Kaewsaneha

Opaprakasit

et al. 2021

Advanced Drug Delivery Reviews

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Section: Enzyme-responsive Gatesmentioning

confidence: 99%

Smart gating porous particles as new carriers for drug delivery

Thananukul

Kaewsaneha

Opaprakasit

et al. 2021

Advanced Drug Delivery Reviews

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“…The openings are then blocked by enzyme-responsive materials to control the drug release process. Since the enzyme-responsive blocker and drug loading are mutually independent, the drug can be loaded without chemical modification. , …”

Section: Design Of Enzyme-assisted Nanocarriersmentioning

confidence: 99%

“…An enzyme-sensitive door is then designed to lock the PS inside, and the key to the door is the designated enzyme. For example, Qu et al prepared UCNP@mSiO 2 -Ce6&DOX-SGFLG-Tf NPs . UCNP@mSiO 2 , Ce6, and SGFLG peptide were the mesoporous carrier, PS, and cathepsin B-cleavable door, respectively.…”

Section: Mechanisms Of Nano-ezpdtmentioning

confidence: 99%

Enzyme-Assisted Photodynamic Therapy Based on Nanomaterials

Tung

2020

ACS Biomater. Sci. Eng.

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Photodynamic therapy (PDT) is a noninvasive cancer treatment that requires the copresence of a photosensitizer (PS), oxygen, and light. The efficacy of conventional PDT is usually limited by two factors: delivery of the PS to the tumor and the hypoxic solid tumor environment. To improve the efficacy of PDT, nanomaterial-based, enzyme-assisted PDT (nano-ezPDT), which integrates enzyme-responsive components into nanomedicines, was developed for enhanced PS delivery and oxygen generation. Nano-ezPDT is designed to take full advantage of the catalytic function of locally activated tumor-associated enzymes or smuggled exogeneous enzymes. The enhancement of PS release and accumulation is often controlled by endogenous enzymes upregulated at the tumor sites. Oxygen generation, however, relies mostly on catalase-loaded nanomedicines. In this review, we discuss the associated enzymes, constructs, and types of nanocarriers and highlight the principle and utility of nano-ezPDT for cancer therapy.

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“…Cathepsin B-responsive "nanovalves" and succinic acid-tetra peptide conjugates (SGFLG), was designed for synergistic chemotherapy and photodynamic therapy (PDT) to tumors under NIR irradiation. [9] Very recently, synergistic combination of chemotherapy and other therapeutic treatments has received increasing attention in cancer treatment. [10] PDT involving photosensitizer, oxygen, and exogenous light activation, could produce cytotoxic reactive oxygen species (ROS) to trigger tumor cell death.…”

Section: Introductionmentioning

confidence: 99%

“…[ 8 ] In addition, a multifunctional Ce6‐doped nanocomposite (UCNP@mSiO 2 ‐Ce6) containing Cathepsin B‐responsive “nanovalves” and succinic acid‐tetra peptide conjugates (SGFLG), was designed for synergistic chemotherapy and photodynamic therapy (PDT) to tumors under NIR irradiation. [ 9 ]…”

Section: Introductionmentioning

confidence: 99%

Dual‐Targeting Photosensitizer‐Peptide Amphiphile Conjugate for Enzyme‐Triggered Drug Delivery and Synergistic Chemo‐Photodynamic Tumor Therapy

Cheng

Qin

Liu

et al. 2020

Adv Materials Inter

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chemotherapeutic agents to selectively target tumor cells always causes serious side effects on normal tissues. Recently, nano-sized tumor-targeted drug delivery systems (DDSs) that specifically deliver therapeutic agents to desired tumor sites have achieved satisfying outcome in cancer chemotherapy. [1] Among various kinds of nanocarriers, such as inorganic nanomaterials, micelles and liposomes, core-shell structured nanomicelle made from peptide amphiphile (PA) is a class of important nano-sized DDSs in biomedical applications. [2,3] Due to merits of structural and functional diversity, excellent biocompatibility and biodegradability, PA is able to self-assemble to form diverse stable nanostructures such as nanomicelles, nanovesicles, and nanotubes etc. [3] Moreover, PA-based DDSs have been reported to display great potential in drug encapsulation, cell internalization, and specific drug delivery in tumor cells. For example, TAT PAs comprising of a TAT 48-60 peptide and hydrocarbon tails (octanoic acid molecules) could self-assemble into β-sheet structures and transport paclitaxel (PTX) to target tumor cells. [4] A supramolecular peptide-amphiphile (SPAs) comprising of dendritic poly (l-lysine) segment and poly (l-leucine) segment was constructed for intracellular drug delivery of doxorubicin (DOX). Because of non-covalent interactions between two peptide domains, SPAs exhibited pHresponsive DOX release in tumor cells. [5] On the other hand, the distinctive pathophysiological and biological characteristics of tumor environment have been utilized to accelerate drug delivery and stimulate drug release by stimulus-responsive PAbased DDSs. [6] The lysosomal acid protease Cathepsin B, which is highly expressed in various types of metastatic and aggressive tumor cells, has been proved to be able to specifically recognize and cleave a tetra-peptide linker GFLG. [7,16] Much endeavor has been made to fabricate Cathepsin B-responsive DDSs through introducing GFLG linker. An amphiphilic copolymer-gemcitabine conjugate was reported, in which gemcitabine was attached to the hydrophobic segment via GFLG linkage, for enzyme-sensitive drug release and fluorescent imaging-guided cancer therapy. [8] In addition, a multifunctional Ce6-doped nanocomposite (UCNP@mSiO 2-Ce6) containing

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Enzyme and pH-responsive nanovehicles for intracellular drug release and photodynamic therapy

Abstract: An enzyme and pH-responsive nanocomposite was constructed for sensitive intracellular drug release and photodynamic therapy (PDT). The novel nanoplatforms provide the potential application in cancer treatment.

Cited by 22 publications

References 40 publications

Smart gating porous particles as new carriers for drug delivery

Smart gating porous particles as new carriers for drug delivery

Enzyme-Assisted Photodynamic Therapy Based on Nanomaterials

Dual‐Targeting Photosensitizer‐Peptide Amphiphile Conjugate for Enzyme‐Triggered Drug Delivery and Synergistic Chemo‐Photodynamic Tumor Therapy

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