Enzyme-Free Tandem Reaction Strategy for Surface-Enhanced Raman Scattering Detection of Glucose by Using the Composite of Au Nanoparticles and Porphyrin-Based Metal–Organic Framework

Hu, Sen; Jiang, Yuning; Wu, Yiping; Guo, Xiaoyu; Ye, Ying; Wen, Ying; Yang, Haifeng

doi:10.1021/acsami.0c12988

Cited by 107 publications

(52 citation statements)

References 42 publications

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“…Alternatively, surface-enhanced Raman scattering (SERS) as an ultrasensitive spectroscopic analytical technique can identify and quantify analytes based on their unique molecular vibrational fingerprints. − Moreover, SERS is resistant to photobleaching and self-quenching and has a lower background signal than fluorescence imaging. − However, on the one hand, monitoring H 2 O 2 released from cells is challenging due to its rapid diffusion, self-transformation, and dilution to ultralow concentration in the cellular microenvironment. , On the other hand, it is difficult to detect molecules with low Raman scattering cross-sections or with poor affinity to the SERS-active substrates. , These problems severely limit the application of SERS in H 2 O 2 detection.…”

Section: Introductionmentioning

confidence: 99%

In Situ Monitoring of Hydrogen Peroxide Released from Living Cells Using a ZIF-8-Based Surface-Enhanced Raman Scattering Sensor

Jiang

Chen

et al. 2021

Anal. Chem.

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Hydrogen peroxide (H2O2) widely involves in intracellular and intercellular redox signaling pathways, playing a vital role in regulating various physiological events. Nevertheless, current analytical methods for the H2O2 assay are often hindered by relatively long response time, low sensitivity, or self-interference. Herein, a zeolitic imidazolate framework-8 (ZIF-8)-based surface-enhanced Raman scattering (SERS) sensor has been developed to detect H2O2 released from living cells by depositing ZIF-8 over SERS active gold nanoparticles (AuNPs) grafted with H2O2-responsive probe molecules, 2-mercaptohydroquinone. Combining the superior fingerprint identification of SERS and the highly efficient enrichment and selective response of H2O2 by ZIF, the ZIF-8-based SERS sensor exhibits a high anti-interference ability for H2O2 detection, with a limit of detection as low as 0.357 nM. Satisfyingly, owing to the enhanced catalytic activity derived from the successful integration of AuNPs and ZIF, the response time as short as 1 min can be obtained, demonstrating the effectiveness of the SERS sensor for rapid H2O2 detection. Furthermore, the developed SERS sensor enables real-time detection of H2O2 secreted from living cells under phorbol myristate acetate stimulation, as cells can be cultured on-chip. This study will pave the way toward the development of a metal–organic framework-based SERS platform for application in the fields of biosensing and early disease diagnosis associated with H2O2 secretion, thus exhibiting promising potential for future therapies.

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Section: Introductionmentioning

confidence: 99%

In Situ Monitoring of Hydrogen Peroxide Released from Living Cells Using a ZIF-8-Based Surface-Enhanced Raman Scattering Sensor

Jiang

Chen

et al. 2021

Anal. Chem.

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“…As reported by previous studies, nanozymes with peroxidase-like activity have been confirmed to catalyze the Raman-inactive reporter (i.e., LMG) into Raman-active reporters (i.e., MG) in the presence of H 2 O 2 . 35,42 To study the Raman signal amplification catalyzed by the peroxidase-like CeO 2 nanozymes, LMG and H 2 O 2 were selected as the CeO 2 nanozyme substrates. A total of 50 μL of CeO 2 nanozyme (10 mg/mL) and 400 μL of LMG (100 mmol/L) were added to the Tris−HCl buffer (50 mmol/L, pH 7.0) and uniformly mixed.…”

Section: ■ Materials and Methodsmentioning

confidence: 99%

Bio-inspired Nanoenzyme Synthesis and Its Application in A Portable Immunoassay for Food Allergy Proteins

Zhang

Liu

et al. 2021

J. Agric. Food Chem.

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Nanozymes as a cost-effective and robust enzyme mimic have attracted widespread attention in the development of novel analytical methods. Herein, a new nanozyme-enhanced surface-enhanced Raman scattering (SERS) immunoassay platform was successfully developed using a peroxidase-mimicking nanozyme to replace the natural enzymes as a catalytic label of the enzyme-linked immunosorbent assay for the detection of allergy proteins. In this platform, the peroxidase-mimicking nanozymes as a catalytic label could catalyze the oxidation of the Raman-inactive reporter [i.e., leucomalachite green (LMG)] to generate Raman-active malachite green (MG) with H2O2. Moreover, the produced MG Raman signal was further enhanced by the formed Raman “hot spot” through MG-induced gold nanoparticle aggregation, which could be recorded by a portable Raman spectrometer. On this basis, the established nanozyme-enhanced SERS immunoassay showed improved accuracy, high sensitivity, and good selectivity and was used for accurate quantification of α-lactalbumin (α-LA). With this method, α-LA could be detected with a limit of detection as low as 0.01 ng/mL. Moreover, the method was also verified by performing in food samples and showed satisfactory recoveries and high reliability. This study not only provides insight into the use of a nanozyme to establish new analytical methods but also broadens the applications of nanozymes in a food safety assay.

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“…Hu et al developed AuNPs and porphyrin-based MOFs composites (AuNPs/Cu-TCPP(Fe)) for the detection of glucose by exploiting a SERS-transduction method. [187] The AuNPs/ Cu-TCPP(Fe) hybrid was prepared by in situ modification of AuNPs onto the Cu-TCPP(Fe). The authors claimed that AuNPs mimicked the GO x like properties, while Cu-TCPP(Fe) acted as a peroxidase mimicking.…”

Section: (16 Of 28)mentioning

confidence: 99%

Glucose Detection Devices and Methods Based on Metal–Organic Frameworks and Related Materials

Adeel

Asif

Rahman

et al. 2021

Adv Funct Materials

121

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Assessment of glucose concentration is important in the diagnosis and treatment of diabetes. Since the introduction of enzymatic glucose biosensors, scientific and technological advances in nanomaterials have led to the development of new generations of glucose sensors. This field has witnessed major developments over the last decade, as the novel nanomaterials are capable of efficiently catalyzing glucose directly (i.e., act as artificial enzymes, therefore defined nanozymes) or to entrap enzymes that are able to oxidize glucose. Among other nanomaterials, metal-organic frameworks (MOFs) have recently provided a tremendous basis to construct glucose sensing devices. MOFs are large porous crystalline compounds with versatile structural and tuneable chemical properties. In addition, they possess catalytic, peroxidase-like, and electrochemical redox activity. This review comprehensively summarizes the general characteristics of MOFs, their subtypes, and MOF composites, as well as MOF-derived materials employed to construct electrochemical, optical, transistor, and microfluidic devices for the detection of glucose. They include enzymatic, nonenzymatic, wearable, and flexible sensing devices and methods. The review also outlines the design and synthesis of MOFs and the working principles of the different transductionbased glucose sensors and highlights the current challenges and future perspectives.

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Enzyme-Free Tandem Reaction Strategy for Surface-Enhanced Raman Scattering Detection of Glucose by Using the Composite of Au Nanoparticles and Porphyrin-Based Metal–Organic Framework

Cited by 107 publications

References 42 publications

In Situ Monitoring of Hydrogen Peroxide Released from Living Cells Using a ZIF-8-Based Surface-Enhanced Raman Scattering Sensor

In Situ Monitoring of Hydrogen Peroxide Released from Living Cells Using a ZIF-8-Based Surface-Enhanced Raman Scattering Sensor

Bio-inspired Nanoenzyme Synthesis and Its Application in A Portable Immunoassay for Food Allergy Proteins

Glucose Detection Devices and Methods Based on Metal–Organic Frameworks and Related Materials

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