Enzymes of Ketone-Body Utilisation in Human Brain

Page, M A; Williamson, D. H.

doi:10.1016/s0140-6736(71)92044-7

Cited by 74 publications

(25 citation statements)

References 9 publications

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“…2) is in contrast to that of rat brain in the sense that there is no peak activity during development [11,13,19]. Our findings on pig brain CoA transferase resemble the trend in human brain described by P age and W illiam son [14], Although the earlier report from this laboratory [20] suggested that pig brain is deficient of CoA transferase, re-examination of the enzyme activity at optimum succinate concentration (50 min) showed a small, but significant activity.…”

Section: Discussionsupporting

confidence: 55%

Substrate Oxidation and Enzyme Activities of Ketone Body Metabolism in the Developing Pig

Kahng¹,

Sevdalian²,

Tildon³

1974

Neonatology

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Utilization of β-hydroxybutyrate-3-¹⁴C was studied in developing pig brain, heart and kidney slices by following the incorporation of ¹⁴C into CO₂. All three tissues showed the ability to utilize β-hydroxybutyrate for energy purposes. Succinyl-CoA: 3-ketoacid CoA transferase (CoA transferase) and acetoacetyl-CoA thiolase activities were measured in those tissues. Although ketone body concentrations in pig blood are low in fed or fasting conditions, the extrahepatic tissues possess the enzymatic machinery for the ketone body utilization. The ratios of the CoA transferase activity to the rate of substrate oxidation indicate that CoA transferase is a significant enzyme in the ketone body oxidation in pig heart. On the other hand, the results suggest that a second enzyme, acetoacetyl-CoA synthetase, may also be important in the metabolism of ketone bodies in pig brain and kidney.

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Section: Discussionsupporting

confidence: 55%

Substrate Oxidation and Enzyme Activities of Ketone Body Metabolism in the Developing Pig

Kahng¹,

Sevdalian²,

Tildon³

1974

Neonatology

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show abstract

“…Thus during pregnancy humans are prone to develope ketonemia [10], ketone bodies pass the human placenta with a maternal-fetal ratio of 2-1 [12,31,29], and recently it was demonstrated that the enzymes involved in ketone body utilization were present in a human fetal brain of 32 weeks gestation and in infant and adult human brains [26]. Preliminary observations in our department have demonstrated a significant cerebral arteriovenous difference of acetoacetate and /J-hydroxybutyrate in children aged 6 weeks to 7 years.…”

Section: Discussionmentioning

confidence: 99%