2016
DOI: 10.4292/wjgpt.v7.i1.66
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Eosinophilic esophagitis: New insights in pathogenesis and therapy

Abstract: Eosinophilic esophagitis (EoE) is a clinico-pathological entity with esophageal symptoms and dense esophageal eosinophilic infiltration throughout the esophagus that may persist despite treatment with proton pump inhibitors. This eosinophilic infiltration is usually absent in the stomach, small intestine and colon, although there are a number of reports of patients with a multiorgan involvement. EoE is associated with abnormalities involving TH2-dependent immunity, with multiple environmental factors strongly … Show more

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Cited by 17 publications
(28 citation statements)
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“…Caucasian ethnicity is more commonly interested in EoE, with a reported predominance of 90% in some case studies. However, the disease can affect also African American, Asian, Native American and Hispanic populations [5]. …”
Section: Eosinophilic Esophagitismentioning
confidence: 99%
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“…Caucasian ethnicity is more commonly interested in EoE, with a reported predominance of 90% in some case studies. However, the disease can affect also African American, Asian, Native American and Hispanic populations [5]. …”
Section: Eosinophilic Esophagitismentioning
confidence: 99%
“…In fact, it is expressed in esophageal mucosa 53 times more than in healthy subjects. The alteration is represented by SNP in the 3′ untranslated region of eotaxin-3 gene [5, 9]. …”
Section: Pathogenesismentioning
confidence: 99%
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