Eosinophilic Granuloma of the Orbit with Spontaneous Healing

Glover, A. Tyrone; Grove, Arthur S.

doi:10.1016/s0161-6420(87)33352-4

Cited by 51 publications

(25 citation statements)

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“…The acute disseminate form, Letterer-Siwe syndrome and chronic form, Eosinophilic granulomatosis, Hand-Schuller-Christian disease, are different in prognosis and clinical features. Generally, if Langerhans' cell histiocytosis is confined in the orbit, its progression is slow and it can be treated by excision, steroid therapy, and radiation therapy (Moore et al 1985;Glover & Grove 1987). The prognosis of the disease is good; however, if intraocular involvement is found, the prognosis is extremely poor.…”

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confidence: 99%

Choroidal Langerhans' cell histiocytosis

Kim

Lee

2000

Acta Ophthalmologica Scandinavica

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ABSTRACT.Purpose: To report a patient with choroidal Langerhans' cell histiocytosis. Methods: A solitary tumor was found in the left eye of a 49-year-old male who had no definite history of systemic disorders, but had observed visual disturbances for a period of 1 month. Ultrasonography, fluorescein angiography, and indocyanine green angiography were performed and the eyeball was enucleated. We prepared the specimen for microscopic examinations. Results: Fluorescein angiographic findings of the lesion were mottled hyperfluorescence in the arteriovenous phase and strong hyperfluorescence in the late phase. Hypofluorescence in both early and late phases showed on indocyanine green angiogram. The lesion of choroid was widely infiltrated by histiocytes, though no extraocular invasion was found. Immunohistochemical studies including S-100 and CD 68 staining revealed characteristic features of Langerhans' cell histiocytosis. Electron microscopic examination of the histiocytes showed histiocytosis X body (Birbeck granule) in the cytoplasm and indented nucleus. Conclusion: We consider that this is a case of choroidal Langerhans' cell histiocytosis with no evidence of systemic lesions.

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Choroidal Langerhans' cell histiocytosis

Kim

Lee

2000

Acta Ophthalmologica Scandinavica

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“…(1,5). Eosinophilic granuloma is a relatively rare disease and accounts for only 1% of all tumour-like lesions of bone (4,9,12). EG is the most benign and most common variant of LCH.…”

Section: öZmentioning

confidence: 99%

Orbital eosinophilic granuloma in a child: a case report

Kahiloğulları¹,

Tuna²,

Kuzu³

et al. 2012

Turkish Neurosurgery

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Eosinophilic granuloma is a rare disease belonging to the Langerhans' cell histiocytosis group. It accounts for only 1% of all tumor-like lesions of bone. A 6-year-old girl presented with proptosis, and a mass and pain in her right eye. Cranial computerized tomography and magnetic resonance imaging revealed a mass in her right orbital area. The patient was operated through a right frontotemporal craniotomy and orbitozygomatic osteotomy. The tumour was totally removed. The postoperative course was uneventful. Histopathological examination revealed a diagnosis of eosinophilic granuloma with typical Langerhans cells and eosinophylic leucocyte infiltration. We report an orbital eosinophilic granuloma case, which is rarely seen, and discuss its clinical and pathological features. KeywOrds: Eosinophilic granuloma, Orbital tumour, Child ÖZEozinofilik granüloma, Langerhans hücreli histiositozis grubunda yer alan nadir bir hastalıktır. Kemiğin tümöre benzer lezyonlarının yalnızca %1'ini oluşturur. Altı yaşında bir kız çocuk, sağ gözde proptozis ve kitle ile sağ gözde ağrı şikâyetleriyle kliniğe başvurdu. Kranial tomografi ve magnetik rezonans görüntülemede sağ orbital bölgede kitle tespit edildi. Hasta sağ frontotemporal kraniotomi ve orbitozigomatik osteotomi ile opere edildi. Kitle total olarak çıkarıldı. Hastada operasyon sonrası herhangi bir komplikasyon gelişmedi. Histopatolojik tanı değerlendirmesi tipik Lagerhans hücreleri ve eozinofilik lökosit infiltrasyonu ile birlikte eozinofilik granülom olarak geldi. Çalışmamızda, orbital bölgenin çok nadir görülen bir tümörü olan eozinofilik granüloma olgusu klinik ve patolojik özellikleri ile sunuldu.

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“…Atualmente, as diferentes formas da HCL são consideradas como uma única desordem da infância que afeta ossos, órgãos parenquimatosos e pele, com espectro clínico de diferentes apresentações, variando desde uma lesão óssea solitária, o GE, até a forma mais agressiva com disfunção multisistêmica (Letterer-Siwe) (2) . Apesar da genérica denominação, HCL ser recomendada por alguns autores para nomear todo o espectro de apresentações clínicas das histiocitoses de células de Langerhans (2)(3) , a expressão "granuloma eosinofílico" (GE) é amplamente utilizada para designar quadros de HCL formados por lesões ósseas localizadas (4)(5)(6) . A maioria dos pacientes com GE apresenta envolvimento da cabeça e pescoço, sendo a órbita um local de freqüente manifestação e com possibilidades terapêuticas variadas (7) .…”

Section: R E S U M O I N T R O D U ç ã Ounclassified

“…As principais formas de tratamento envolvem quimioterapia, radioterapia, excisão cirúrgica e injeção local de corticosteróides (6,9,12,14) . Apesar do tratamento do GE orbitário ser pouco discutido na literatura, (25 casos nos últimos 20 anos nos bancos de dados Medline e Probe/Elsevier), a evolução parece ser benigna nos casos estritamente unifocais de origem óssea, mas também em alguns casos que se originam de tecidos moles (5)(6)(8)(9)(11)(12)14) . Nesse sentido, a discussão a respeito da melhor conduta se baseia em fatores de risco locais e sistê-micos.…”

Section: I S C U S S ã Ounclassified

“…Dessa maneira, a ocorrência, como no presente caso, de lesões com remissão espontânea após biópsia (5) e curetagem local (9) abre novas perspectivas terapêuticas. Apesar de não haver confirmação patogênica, pode-se aventar a hipótese de que uma pequena desorganização na estrutura do granuloma, tal qual a efetuada por uma biópsia, venha desencadear grande destruição da massa e estímulo para regeneração e cicatrização óssea.…”

Section: I S C U S S ã Ounclassified

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