Epidemiología molecular de aislados de Acinetobacter baumannii resistentes a carbapenems en Argentina

Rodríguez, Carlos Hernán; Nastro, Marcela; Flores, Silvia Alicia; Rodríguez, María del Pilar García; Spinozzi, Mariela; Bruni, Geni; Lopez, Ana Liza C.; David, Viviana; Aiassa, Maria S; Marques, I. C. S.; Navarro, Osvaldo R; Paniccia, Laura; Famiglietti, Ángela; Argentina, Grupo colaborativo Acinetobacter

doi:10.1016/j.ram.2017.12.004

Cited by 7 publications

(8 citation statements)

References 11 publications

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“…CRAB is a perilous nosocomial pathogen causing substantial morbidity and mortality, which is a severe health threat and economic burden (Carlos et al, 2017;Isler et al, 2018). Hospital setting is an important reservoir for CRAB transmission (Raro et al, 2017;Opazo-Capurro et al, 2019).…”

Section: Discussionmentioning

confidence: 99%

Molecular Epidemiology and Clone Transmission of Carbapenem-Resistant Acinetobacter baumannii in ICU Rooms

Zhang

Awan

et al. 2021

Front. Cell. Infect. Microbiol.

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Carbapenem-resistant Acinetobacter baumannii (CRAB) is a major cause of nosocomial infections and hospital outbreaks worldwide, remaining a critical clinical concern. Here we characterized and investigated the phylogenetic relationships of 105 CRAB isolates from an intensive care unit from one hospital in China collected over six years. All strains carried blaOXA-23, blaOXA-66 genes for carbapenem resistance, also had high resistance gene, virulence factor, and insertion sequence burdens. Whole-genome sequencing revealed all strains belonged to ST2, the global clone CC2. The phylogenetic analysis based on the core genome showed all isolates were dominated by a single lineage of three clusters and eight different clones. Two clones were popular during the collection time. Using chi-square test to identify the epidemiologically meaningful groupings, we found the significant difference in community structure only existed in strains from separation time. The haplotype and median-joining network analysis revealed genetic differences appeared among clusters and changes occurred overtime in the dominating cluster. Our results highlighted substantial multidrug-resistant CRAB burden in the hospital ICU environment demonstrating potential clone outbreak in the hospital.

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Section: Discussionmentioning

confidence: 99%

Molecular Epidemiology and Clone Transmission of Carbapenem-Resistant Acinetobacter baumannii in ICU Rooms

Zhang

Awan

et al. 2021

Front. Cell. Infect. Microbiol.

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“…Concerning our local epidemiology, recent studies of Carbapenem Resistant A. baumannii (CRAB) isolates, revealed that GC1 is the most widespread and common clone of CRAB in Argentina (Rodríguez et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Crucial Role of the Accessory Genome in the Evolutionary Trajectory of Acinetobacter baumannii Global Clone 1

et al. 2020

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Frontiers in Microbiology | www.frontiersin.org March 2020 | Volume 11 | Article 342 Álvarez et al. Accessory Genome in IC1versus A118 (ST 404/ND) without antimicrobial pressure suggested a higher ability of GC1 to grow over a clone with sporadic behavior which explains, from an ecological perspective, the global achievement of this successful pandemic clone in the hospital habitat. Together, these data suggest an essential role of still unknown properties of "mobile" and "sedentary" accessory genome that is preserved over time under different antibiotic or stress conditions.

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“…The most common sequence types in the region were ST79, ST25, ST1 and ST15. ST79 had the widest geographic spread, and was detected in Ecuador, Peru, Brazil, Paraguay, Uruguay and Argentina, [34,35,39,43,45] which implies greater current dissemination than had been reported earlier (in a review carried out in 2018). [59] ST25 was detected in Bolivia, Paraguay, Uruguay and Argentina, [39,43] baumannii clones ST191 and ST369 has also been reported in China and South Korea.…”

Section: Review Articlementioning

confidence: 88%

Carbapenamase-Producing Acinetobacter baumannii in China, Latin America and the Caribbean: A Systematic Review and Meta-Analysis

Ezpeleta

et al. 2022

MEDICC Review

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INTRODUCTION Carbapenem-resistant Acinetobacter baumannii is a complex health problem, causing diffi culties in clinical-therapeutic management worldwide. It is of particular concern in Latin America, the Caribbean and China, where it is an emerging health problem. Carbapenemases produced by these organisms inactivate carbapenem antibiotics. Monitoring circulating genotypes' geographic dispersion contributes to more eff ective control measures. However, exhaustive studies on carbapenem-resistant A. baumannii are scarce.OBJECTIVES Study the production of carbapenemases in clinical isolates of A. baumannii resistant to carbapenem antibiotics and the geographic distribution of the sequences circulating in China, Latin America and the Caribbean. DATA ACQUISITIONWe followed PRISMA indications. We carried out a systematic search in Pubmed, BVS and CKNI on papers on A. baumannii and carbapenemases published during 2015-2020 in English, Spanish and Chinese, and selected 29 cross-sectional studies that met the search criteria. Studies were evaluated using JBI Critical Appraisal tools, and quantitative data were collated for meta-analysis using the Metaprop library in Stata15.DEVELOPMENT OXA-type carbapenemases were detected in all studies; among A. baumannii resistant to carbapenem antibiotics, predominant types were OXA-23, OXA-24, OXA-54 and OXA-72; metallobetalactamases were identifi ed less frequently than OXA carbapenemases. Only one clinical isolate producer of Class A carbapenemases (KPC) was identifi ed in Colombia. In total, 41 sequence types were identifi ed; in Latin America and the Caribbean the most common types were: ST79, ST25, ST1 and ST15; in China, the sequences ST195, ST208, ST191, ST368 and ST369 were the most prevalent. ST2 was found in both regions. CONCLUSIONSThe most prevalent carbapenemases and sequence types vary by region, indicating diff erent ancestral strains. Microbiological surveillance, antibiotic use optimization, adequate infection treatment and timely control strategies are essential for carbapenem-resistant A. baumannii prevention and control in geographies such as Latin America, the Caribbean and China where such resistance is an emerging health problem.

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Epidemiología molecular de aislados de Acinetobacter baumannii resistentes a carbapenems en Argentina

Cited by 7 publications

References 11 publications

Molecular Epidemiology and Clone Transmission of Carbapenem-Resistant Acinetobacter baumannii in ICU Rooms

Molecular Epidemiology and Clone Transmission of Carbapenem-Resistant Acinetobacter baumannii in ICU Rooms

Crucial Role of the Accessory Genome in the Evolutionary Trajectory of Acinetobacter baumannii Global Clone 1

Carbapenamase-Producing Acinetobacter baumannii in China, Latin America and the Caribbean: A Systematic Review and Meta-Analysis

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