Epidemiologic analysis of salivary gland tumors over a 10-years period diagnosed in a northeast Brazilian population

Abstract

Background Salivary gland tumors (SGT) correspond to a heterogeneous group of lesions with variable biological behavior. The present study aimed to determine the distribution and demographic findings of salivary gland neoplasms in a northeast Brazilian population. Material and Methods A retrospective descriptive cross-sectional study was performed. A total of 588 cases of SGT were diagnosed between 2006 and 2016 of 4 pathology services in the state of Sergipe, Brazil. All cases were reviewed, and data such as sex, age, anatomical location, and histopathological diagnosis were collected. Results A total of 470 (79.9%) tumors were benign and 118 (20.1%) were malignant. The majority of the patients were females (n=328, 55.8%) with an overall female:male ratio of 1.2:1. The major salivary glands were affected more than the minor glands (69.5% vs. 30.5%). Pleomorphic adenoma (n=419, 71.3%) and mucoepidermoid carcinoma (n=29, 4.9%) were the most frequent benign and malignant tumors, respectively. In addition, both benign and malignant tumors occurred more frequently in the parotid gland (n=300, 51%, p <0.05). Conclusions The epidemiologic profile and clinical characteristics of SGT were similar to those described in other countries and other regions of Brazil. Epidemiological studies of SGT help to understand their clinical and pathological features and are essential to establish the proper management and prognosis. Key words: Salivary gland, tumors, epidemiology, head and neck pathology.

Incidence and profile of benign epithelial tumors of salivary glands from a single center in Northeast of Brazil

“…An important aspect to consider is that the tumors analyzed derived from a medical pathology center (general pathology service), instead of an oral pathology service. It has been shown ( 3 , 25 ) that in medical services the most common location for benign salivary gland neoplasms is the parotid gland in which PA and WT are the most frequent tumors as we observed in the present study. In the other hand, in an oral pathology laboratory most lesions diagnosed are from the minor salivary glands, especially the palate, evidencing a different distribution profile.…”

“…In general, other authors indicate that nearly 2.5 to 6.8% of all PA present malignant transformation ( 4 , 6 , 10 ). As showed in Table 3 , studies in Brazil show variation in the percentage of CAEXPA, however, the transformation rate in general is between 1 and 5% ( 3 , 7 , 17 , 23 - 25 ). In our analysis, of the 178 cases diagnosed as PA, there was malignant transformation in 7 patients, representing 3.9% of the cases.…”

Salivary Gland Tumors: A Retrospective Study of 164 Cases from a Single Private Practice Service in Mexico and Literature Review

“…Due to its complex histology, a variety of primary tumors can develop in these structures independently of the anatomical site [1,2]. Also, the morphological diagnosis of these lesions is frequently challenging due to many histological subtypes, overlapping of morphological findings, and different classifications [2][3][4].…”

“…Although several epidemiological studies across the world have evaluated the frequency and incidence of these tumors [2, 3, 5-16], geographic variations have been observed in this group of lesions, particularly in relation to anatomical location and histological subtypes [2, 3,8]. In addition, there are only a few studies about the incidence in the Mexican population, despite its large geographical size and population [14].…”

2021 Update on Diagnostic Markers and Translocation in Salivary Gland Tumors

“…Based on the known entities, it can be highlighted that epithelial salivary gland tumors consist of 10 benign and 23 malignant subtypes, which are the most commonly prevailing in daily clinical life [3]. The primary problem lies in diagnosing a salivary gland tumor, as it is a relatively uncommon form of lesion with wide variations in histological and biological aspects [4]. These tumors have a significant morphological diversity with multiple overlapping features and low incidence rates [5].…”