Epidemiologic Approaches to Assessing Human Cancer Risk from Consuming Aquatic Food Resources from Chemically Contaminated Water

Ozonoff, David; Longnecker, Matthew P.

doi:10.2307/3430858

Cited by 6 publications

(1 citation statement)

References 10 publications

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“…Moreover, loss of specific regulatory functions (i.e., tumor suppressor genes) represents an important feature in neoplastic transformation (91)(92)(93). This further permits us to come closer to the public health objective of preventing (or reducing) chemically induced and chemically associated cancers in humans (94)(95)(96)(97)(98)(99).…”

Section: Chemical Carcinogenesismentioning

confidence: 99%

Carcinogenesis Studies in Rodents for Evaluating Risks Associated with Chemical Carcinogens in Aquatic Food Animals

Huff¹,

Bucher²,

Yang³

1991

Environmental Health Perspectives

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FIsh and selish caught in polluted waters contain poentially dangerous amounts ofti an carcinogenic l Public concern was heightened when a large percentage ofwinter founder taken from Boston Harbor wa found to have visiblecancer ofthe Diver; winterflounderoutsidetheesuary ara had no livwerlesons. LIng-tenn cbemicalcardnogenesis sudies could be esily and feasibly designd using laboratory rodentsoffred diet _contaling fshcaught in pollted waters.Induced cancers in rodents would corroborate field observations in fish; positive results from these studies would provide futhe evienc about potenti human health hazards from eaing s l amounts of emlly ontaminated fish. Nonetheless, fish and aquatic orgnisms should be viewed as environmental biological monitors of polution or of potential human heth harwds, and authoritis responsible for asuring clan and safe rivers, bodies ofwater, and biota should give more attention to these valid biological indicators or sentinels ofenvhinmental polution. Consequendy, fish and other sea creatures alone should serve as alarms regarding whether water areas constitute public health hazards.

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Section: Chemical Carcinogenesismentioning

confidence: 99%

Carcinogenesis Studies in Rodents for Evaluating Risks Associated with Chemical Carcinogens in Aquatic Food Animals

Huff¹,

Bucher²,

Yang³

1991

Environmental Health Perspectives

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Pathology and toxicology of beluga whales from the St. Lawrence Estuary, Quebec, Canada. Past, present and future

Martineau

Guise

Fournier

et al. 1994

Science of The Total Environment

161

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An indigenous population of 450-500 beluga whales (Delphinapterus leucas) inhabiting the St. Lawrence Estuary has been exposed chronically for more than 50 years to a complex mixture of industrial pollutants including organochlorinated compounds (OC), polycyclic aromatic hydrocarbons (PAH) and heavy metals. From 1983 to 1990, we have necropsied 45 well preserved carcasses out of a total of 120 beluga whales reported dead over this period. Of these 45 animals, nine were affected by 10 malignant neoplasms. Fifteen animals (33%) were affected by pneumonia. Milk production was compromised in eight of 17 mature females (41%), by inflammatory changes (seven animals) and cancer (one animal) which affected the mammary glands. Opportunistic bacteria were found in pure culture, and/or in significant amounts in at least two organs in 20 belugas (44%). The concentrations of both total PCBs and highly chlorinated PCB congeners were much higher in St. Lawrence animals than in Arctic beluga whales. OC-induced immunosuppression has been repeatedly demonstrated in a wide variety of animal species. Therefore, it is probable that the immune functions of St. Lawrence beluga whales are impaired. Benzo[a]pyrene adducts were detected in 10 of the 11 St. Lawrence beluga whales of which tissues (six livers, 10/11 brains) were analyzed by a method based on HPLC. No such adducts were found in four Arctic animals. Since benzo[alpha]pyrene is one of the most potent chemical carcinogens known to man, these compounds might be responsible for some of the cancers observed in that population. Overall, our findings contrast vividly with those of others who found that cancers are exceedingly rare in free-ranging odontocete populations and that the major causes for mortalities in these populations are bacteria, parasites, and trauma.

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Chemical residues in foods of animal origin: overview and risk assessment

Waltner-Toews

McEwen

1994

Preventive Veterinary Medicine

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Epidemiologic Approaches to Assessing Human Cancer Risk from Consuming Aquatic Food Resources from Chemically Contaminated Water

Cited by 6 publications

References 10 publications

Carcinogenesis Studies in Rodents for Evaluating Risks Associated with Chemical Carcinogens in Aquatic Food Animals

Carcinogenesis Studies in Rodents for Evaluating Risks Associated with Chemical Carcinogens in Aquatic Food Animals

Pathology and toxicology of beluga whales from the St. Lawrence Estuary, Quebec, Canada. Past, present and future

Chemical residues in foods of animal origin: overview and risk assessment

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