Epidemiological and clinical characteristics of classic Kaposi's sarcoma in Peru

Mohanna, Salim; Ferrufino, Juan Carlos; Sánchez, Juvenal; Bravo, Francisco; Gotuzzo, Eduardo

doi:10.1016/j.jaad.2005.05.041

Cited by 32 publications

(32 citation statements)

References 52 publications

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“…The mean age of CKS in the combination of all these studies was of 67.9 years, very similar to our results of 68.9 years.…”

Section: Discussionsupporting

confidence: 90%

“…Most of the cohorts of CKS patients found in the literature reporting such information were conducted in high‐endemic countries, most of them in the Mediterranean area (Israel, Greece, Italy, Morocco and Tunisia). Another study reports with details the presentation of CKS in Peru, with a total of 1318 patients. A huge cohort study of 438 patients was conducted in the USA; however, the authors may have included patients seropositive for HIV as the recruitment started before 1980.…”

Section: Discussionmentioning

confidence: 99%

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A fifth subtype of Kaposi's sarcoma, classic Kaposi's sarcoma in men who have sex with men: a cohort study in Paris

Denis

Seta

Régnier‐Rosencher

et al. 2018

Acad Dermatol Venereol

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“…The mean age of CKS in the combination of all these studies was of 67.9 years, very similar to our results of 68.9 years.…”

Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

A fifth subtype of Kaposi's sarcoma, classic Kaposi's sarcoma in men who have sex with men: a cohort study in Paris

Denis

Seta

Régnier‐Rosencher

et al. 2018

Acad Dermatol Venereol

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“…In Latin America, HHV-8 prevalence in the general population of Latin America has been described as low(12, 13), but rural populations with a high prevalence of antibodies to HHV-8 have been described in Brazil(14) and Peru(15). The moderate seroprevalence of HHV-8 among HIV-negative MSM in our study suggests that the previous reports of high HHV-8 seroprevalence and KS incidence(16) among the persons in Peru suggests that there may be substantial heterogeneity in the prevalence of HHV-8 infection among residents of Peru, and bears further study.…”

Section: Discussionsupporting

confidence: 50%

Prevalence and Correlates of Human Herpesvirus 8 Infection Among Peruvian Men Who Have Sex With Men

Guanira¹,

Casper²,

Lama³

et al. 2008

JAIDS Journal of Acquired Immune Deficiency Syndromes

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Background Infection with human herpesvirus 8 (HHV-8) is common among men who have sex with men (MSM) in North America and Europe, and is also found to be endemic in some regions of South America. Little is known about HHV-8 prevalence and its correlates among MSM in the Andean region. Methods We assessed HHV-8 seroprevalence among 497 MSM recruited for the 2002 Peruvian HIV sentinel surveillance program using a combined HHV-8 enzyme immunoassay and immunofluorescence assay algoritm. Logistic regression was used to estimate Odds Ratios (OR) and their 95% confidence intervals (CI) to determine the association between selected covariates and HHV-8 seropositivity. Results 483 (97%) of 497 men had stored sera and demographic data available for analysis. 131 (66.5%, 95% CI 63.1%-69.9%) of 197 HIV-infected and 80 (26.7%, 95% CI 24.4%-29.0%) of 300 HIV-uninfected MSM had serologic evidence of HHV-8 infection. Factors independently associated with HHV-8 infection were education <12 years (OR 1.7, 95% CI 1.1-2.7), anal receptive sex with the last partner (OR 2.0, 95% CI 1.2-3.3), self-reported STI symptoms during the last year (OR: 1.9, 95% CI 1.2-3.0), and co-infection with HIV (OR 4.2, 95% CI 2.8-6.4) and Chronic Hepatitis B (OR 4.9, 95% CI 1.5-15.8). MSM with long-standing HIV infection were more likely to have serologic evidence of HHV-8 infection when compared to men with recently-acquired HIV (OR: 3.8, 95% CI 1.7-9.1). Conclusions HHV-8 infection is common among both HIV-infected and negative MSM in Lima, Peru. HHV-8 seropositivity is correlated with anal receptive sex, self-reported STI symptoms, and HIV infection among these MSM, and thus appears to be sexually transmitted. HHV-8 infection appears to be acquired after HIV infection, suggesting that future studies should evaluate the mode of HHV-8 transmission and prevention strategies among HIV-infected MSM.

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“…However, the pattern and prevalence vary between these countries. 70 It is therefore imperative to assess the role of HHV-8 in pulmonary vascular disease in endemic areas to provide further information on the role, if any, of this virus in the pathobiology of pulmonary hypertension, therefore providing a reasonable model to study the controversial role of HHV-8 infection in the pathogenesis of pulmonary hypertension.…”

Section: Pulmonary Vascular Disease Associated With Human Herpesvirusmentioning

confidence: 99%

Pulmonary Vascular Disease in the Developing World

2008

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Epidemiological and clinical characteristics of classic Kaposi's sarcoma in Peru

Cited by 32 publications

References 52 publications

A fifth subtype of Kaposi's sarcoma, classic Kaposi's sarcoma in men who have sex with men: a cohort study in Paris

A fifth subtype of Kaposi's sarcoma, classic Kaposi's sarcoma in men who have sex with men: a cohort study in Paris

Prevalence and Correlates of Human Herpesvirus 8 Infection Among Peruvian Men Who Have Sex With Men

Pulmonary Vascular Disease in the Developing World

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