Epidemiological and clinical profile of patients with Chagas disease in the Central-North area of Paraná, Southern Brazil

Gasparim, Aretuza Zaupa; Fontes, Carlos Edmundo Rodrigues; Rossoni, Diogo Francisco; Toledo, Max Jean de Ornelas

doi:10.1590/0037-8682-0173-2017

Cited by 15 publications

(19 citation statements)

References 8 publications

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“…In Brazil, the highest prevalence of CD is in the Northeastern and Southeastern regions 16 . In contrast, only two studies of CD have been done in the state of Paraná (Southern Brazil) and these were from the Central-North area 17,18 . Moreover, in general, the distribution of the chronic cases of CD is silent and the numbers are underestimated due to the lack of surveillance and notification.…”

Section: Introductionmentioning

confidence: 99%

Clinical and epidemiological aspects of chronic Chagas disease from Southern Brazil

Lidani

Sandri

Castillo-Neyra

et al. 2020

Rev. Soc. Bras. Med. Trop.

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Introduction: Patients with Chagas disease (CD), caused by Trypanosoma cruzi, present a higher risk of developing other chronic diseases, which may contribute to CD severity. Since CD is underreported in the southern state of Paraná, Brazil, we aimed to characterize clinical and epidemiological aspects of individuals chronically infected with T. cruzi in Southern Brazil. Methods: A community hospital-based study was performed, recording clinical/demographic characteristics of 237 patients with CD from Southern Brazil. To estimate the association between different forms of CD and sociodemographic and clinical variables, multiple logistic regression models were built using the Akaike information criterion. Results: Mean age was 57.5 years and 59% were females. Most patients' (60%) place of origin/birth was within Paraná and they were admitted to the CD outpatient clinic after presenting with cardiac/digestive symptoms (64%). The predominant form of CD was cardiac (53%), followed by indeterminate (36%), and digestive (11%). The main electrocardiographic changes were in the right bundle branch block (39%) and left anterior fascicular block (32%). The average number of comorbidities per patient was 3.9±2.3; systemic arterial hypertension was most common (64%), followed by dyslipidemia (34%) and diabetes (19%); overlapping comorbidities were counted separately. Male sex was associated with symptomatic cardiac CD (OR=2.92; 95%CI: 1.05-8.12; p=0.040). Conclusions: This study provided greater understanding of the distribution and clinical profile of CD patients in Southern Brazil, indicating a high prevalence of comorbidities among these patients who are a vulnerable group due to advanced age and substantial risk of morbidity.

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Section: Introductionmentioning

confidence: 99%

Clinical and epidemiological aspects of chronic Chagas disease from Southern Brazil

Lidani

Sandri

Castillo-Neyra

et al. 2020

Rev. Soc. Bras. Med. Trop.

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“…The fact of having been born in Canguçu, is in agreement with a study conducted by Rosenthal et al (2016), since the authors found that patients from this municipality, presented a 6.57 higher chance of having anti-T. cruzi antibodies. Regarding aspects attributed to the epidemiology of CD, Gasparim et al (2018) conducted a study with 270 individuals positives in the state of Paraná, south of the Brazil, and the majority of those infected were over 65 years old, lived in the urban area and were infected in childhood through the CD vectors. Considering the clinical manifestations of the disease, 36% corresponded to the cardiac form, 30% to the indeterminate form, 20% to the cardiodigestive form and 14% to the digestive form.…”

Section: Discussionmentioning

confidence: 99%

Seroprevalence of Chagas disease in Southern Brazilian cardiac patients and their knowledge about the parasitosis and vectors

et al. 2021

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Chagas disease (CD) is considered a typical low-income population sickness of the developing countries in Latin America. Given the historical relevance of CD in individuals in southern Rio Grande do Sul (RS) State, Brazil, the aim of this study was to identify the knowledge of the CD and its vectors by cardiac patients, and the prevalence of anti-T cruzi antibodies in these individuals in Pelotas, city located in Rio Grande do Sul (RS) state, Brazil. The subjects with cardiac disease were submitted to a semi-structured questionnaire as well as two serological tests in order to detect anti-T. cruzi IgG antibodies. Of the individuals that born in municipalities showing the highest triatomine infestation rates in recent decades, 81.8% were able to recognize the vector insect (p = 0.0042; OR = 5.9), and 83.3% reported either themselves or someone in their families to have CD (p = 0.043, OR = 5.2). Of the 54 patients submitted to serological analysis, only 01 patient (1.9%) was positive for anti-T. cruzi antibodies, a 55 year old man from the rural area of Canguçu county. This study provides support for the evaluation to be extended to other cardiology centers, given the importance of Chagas disease in Brazil.

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“…A principal e mais conhecida forma de transmissão é a vetorial, no entanto outras formas de contaminação são comumente descritas como a via oral, a materno-fetal, sangue e hemoderivados, transplantes de órgão ou acidentes com material biológico (BRASIL, 2017). Outras formas de transmissão como oral, transplacentária, contaminação com caças silvestres e a presença de outras espécies de triatomíneos com potencial vetorial, contribuem para a continuidade do ciclo parasitário da tripanossomíase (GASPARIM et al, 2018).…”

Section: Introductionunclassified

“…O Brasil conseguiu, em 2006, validar a interrupção da transmissão vetorial do T. cruzi pelo Triatoma infestans, já foi considerado o principal vetor da DC, sendo a Bahia o último estado endêmico da doença a receber o certificado, enquanto Rio Grande do Sul, Tocantins, Paraná, São Paulo, Mato Grosso, Mato Grosso do Sul, Pernambuco, Minas Gerais, Piauí, Paraíba, Distrito Federal, Rio de Janeiro já haviam recebido tal certificação em momentos anteriores (SILVA, 2006). No entanto algumas espécies de triatomíneos estão apresentando potencial vetorial para DC, demonstrando a importância da continuidade do controle vetorial da doença (GASPARIM et al, 2018).…”

Section: Introductionunclassified

Vigilância Epidemiológica E Controle Vetorial: Importância E Desafios Na Transmissão Da Doença De Chagas Em Duas Décadas Na Região Da Estrada De Ferro De Goiás

Machado¹,

Alves²,

Oliveira³

et al. 2020

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Epidemiological and clinical profile of patients with Chagas disease in the Central-North area of Paraná, Southern Brazil

Abstract: Patients who were older than 65 years of age, retired, female, living in the urban area of Maringá, and infected by vector transmission in childhood in Paraná presented cardiac and digestive signs and did not receive etiological treatment when first diagnosed.

Cited by 15 publications

References 8 publications

Clinical and epidemiological aspects of chronic Chagas disease from Southern Brazil

Clinical and epidemiological aspects of chronic Chagas disease from Southern Brazil

Seroprevalence of Chagas disease in Southern Brazilian cardiac patients and their knowledge about the parasitosis and vectors

Vigilância Epidemiológica E Controle Vetorial: Importância E Desafios Na Transmissão Da Doença De Chagas Em Duas Décadas Na Região Da Estrada De Ferro De Goiás

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