Epidemiological Characteristics of Traumatic Spinal Cord Injury (TSCI) in the Middle-East and North-Africa (MENA) Region: A Systematic Review and Meta-Analysis

Elshahidi, Mohamed H.; Monir, Nada Y.; Elzhery, Mohamed A.; Sharaqi, Ahmed A.; Haedaya, Hames; Awad, Basem I.; Zaghloul, Khaled

doi:10.29252/beat-060201

Cited by 37 publications

(34 citation statements)

References 29 publications

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“…An epidemiological survey conducted in Canada in 2006 showed that MVCs were the main cause of SCIs, while falls became the main cause in 2009 [17,18]. Another study from seven countries in the Middle-East and North Africa (MENA) region found that MVCs are still the leading cause of SCIs, followed by falls, gunshots, violence, and sports [19]. We found that falls (both from a small and large height) and MVCs were the main causes of SCIs and occurred in nearly all age groups.…”

Section: Discussionmentioning

confidence: 99%

Epidemiological characteristics of spinal cord injury in Northwest China: a single hospital-based study

et al. 2020

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Background: While the cities in China in which spinal cord injury (SCI) studies have been conducted previously are at the forefront of medical care, northwest China is relatively underdeveloped economically, and the epidemiological characteristics of SCI have rarely been reported in this region. Methods: The SCI epidemiological survey software developed was used to analyze the data of patients treated with SCI from 2014 to 2018. The sociodemographic characteristics of patients, including name, age, sex, and occupation, were recorded. The following medical record data, obtained from physical and radiographic examinations, were included in the study: data on the cause of injury, fracture location, associated injuries, and level of injury. Neurological function was evaluated using the American Spinal Injury Association (ASIA) impairment scale. In addition, the treatment and complications during hospitalization were documented. Results: A total of 3487 patients with SCI with a mean age of 39.5 ± 11.2 years were identified in this study, and the male to female ratio was 2.57:1. The primary cause of SCI was falls (low falls 47.75%, high falls 37.31%), followed by traffic accidents (8.98%), and impact with falling objects (4.39%). Of all patients, 1786 patients (51.22%) had complications and other injuries. According to the ASIA impairment scale, the numbers of grade A, B, C, and D injuries were 747 (21.42%), 688 (19.73%), 618 (17.72%), and 1434 (41.12%), respectively. During the hospitalization period, a total of 1341 patients experienced complications, with a percentage of 38.46%. Among all complications, pulmonary infection was the most common (437, 32.59%), followed by hyponatremia (326, 24.31%), bedsores (219, 16.33%), urinary tract infection (168, 12.53%), deep venous thrombosis (157, 11.71%), and others (34, 2.53%). Notably, among 3487 patients with SCI, only 528 patients (15.14%) received long-term rehabilitation treatment. Conclusion: The incidence of SCI in northwest China was on the rise with higher proportion in males; fall and the MCVs were the primary causes of SCI. The occupations most threatened by SCI are farmers and workers. The investigation and analysis of the epidemiological characteristics of SCI in respiratory complications are important factors leading to death after SCI, especially when the SCI occurs in the cervical spinal cord. Finally, the significance of SCI rehabilitation should be addressed.

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Section: Discussionmentioning

confidence: 99%

Epidemiological characteristics of spinal cord injury in Northwest China: a single hospital-based study

et al. 2020

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“…With the development of the modern transportation and construction industries, the incidence of SCI has increased annually ( 2 ). Patients with SCI often exhibit severe motor and sensory paralysis and have a poor prognosis, resulting in heavy familial and societal burdens ( 3 , 4 ). In previous decades, cell transplantation has become a promising therapy for a number of diseases.…”

Section: Introductionmentioning

confidence: 99%

Hypoxic preconditioned bone mesenchymal stem cells ameliorate spinal cord injury in rats via improved survival and migration

et al. 2018

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The unique hypoxic inflammatory microenvironment observed in the spinal cord following spinal cord injury (SCI) limits the survival and efficacy of transplanted bone mesenchymal stem cells (BMSCs). The aim of the present study was to determine whether hypoxic preconditioning (HP) increased the therapeutic effects of BMSC on SCI. BMSCs were pretreated with cobalt chloride (CoCl2) in vitro, and the proliferative apoptotic and migratory abilities of these hypoxic BMSCs (H-BMSCs) were assessed. BMSCs and H-BMSCs derived from green fluorescent protein (GFP) rats were transplanted into SCI rats in vivo. The neurological function, histopathology, inflammation, and number and migration of transplanted cells were examined. HP significantly enhanced BMSC migration (increased hypoxia inducible factor 1α and C-X-C motif chemokine receptor 4 expression) and tolerance to apoptotic conditions (decreased caspase-3 and increased B-cell lymphoma 2 expression) in vitro. In vivo, H-BMSC transplantation significantly improved neurological function, decreased spinal cord damage and suppressed the inflammatory response associated with microglial activation. The number of GFP-positive cells in the SCI core and peripheral region of H-BMSC animals was increased compared with that in those of BMSC animals, suggesting that HP may increase the survival and migratory abilities of BMSCs and highlights their therapeutic potential for SCI.

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Section: Contextmentioning

confidence: 99%

“…Spinal cord injury (SCI) is a type of damage that transforms the individual's performance in permanent or temporary form (1). These alterations happen due to lack of muscular, sensory, or autonomic nervous function in the parts below lesion level (1). The injury may occur in spinal cord at any levels, leading to complete or proportional injuries and loss, and muscular dysfunction of one or all senses (2).…”

Section: Contextmentioning

confidence: 99%

“…The injury may occur in spinal cord at any levels, leading to complete or proportional injuries and loss, and muscular dysfunction of one or all senses (2). According to the position and severity of SCI, the symptoms can vary extensively from pain or numbness to paralysis or incontinence (1,2). Short-term and long-term complications associated with SCI include muscular atrophy, pressure ulcers (PUs), infections, and respiratory problems (1,2).…”

Section: Contextmentioning

confidence: 99%

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The Effect of Remote Patient Monitoring on Patients with Spinal Cord Injury: A Mini-Review

2019

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Context: Studies revealed that remote patient monitoring can be effective in the prevention and control of complications in patients with spinal cord injury. However, there are a limited number of researches in this domain with contradictions in some cases. Thus, the current study aimed at investigating the impact of remote patient monitoring on patients with spinal cord injury (SCI). Methods: The current descriptive retrospective study searched databases such as Elsevier, Google Scholar, and PubMed in English from 1977 to 2018. After going throw the required procedures, 40 articles were finally confirmed and enrolled in the current study. Conclusions: The results of the current study revealed that the application of remote patient monitoring system was influential and promising in the prevention and control of complications in patients with SCI. Therefore, they can be considered in care planning for such patients.

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Epidemiological Characteristics of Traumatic Spinal Cord Injury (TSCI) in the Middle-East and North-Africa (MENA) Region: A Systematic Review and Meta-Analysis

Abstract: This review shows lack of evidence about SCI in most countries of the MENA region. More epidemiological studies are needed.

Cited by 37 publications

References 29 publications

Epidemiological characteristics of spinal cord injury in Northwest China: a single hospital-based study

Epidemiological characteristics of spinal cord injury in Northwest China: a single hospital-based study

Hypoxic preconditioned bone mesenchymal stem cells ameliorate spinal cord injury in rats via improved survival and migration

The Effect of Remote Patient Monitoring on Patients with Spinal Cord Injury: A Mini-Review

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