Epidemiological Features of Chronic Lung Infection in Patients with Cystic Fibrosis

Шагинян, И А; Чернуха, М Ю; Аветисян, Л Р; Сиянова, Е А; Кулястова, Д. Г.; Medvedeva, O.; Priputnevich, Т.В.; Трофимов, Д. Ю.; Гордеев, А. В.; Кондратьева, Е. И.; Амелина, Е. Л.; Красовский, С. А.

doi:10.31631/2073-3046-2017-16-6-5-13

Cited by 6 publications

(2 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Причому в періоді загострення хронічного бронхіту ці асоціації представлені не двома, а трьома і більше видами мікроорганізмів. Частіше зустрічається асоціація Staphylococcus aureus і Pseudomonas aeruginosa, а також Pseudomonas aeruginosa і Burkholderia cepacia [16].…”

Section: аналіз струêтури та антибіотиêорезистентності етіологічно знunclassified

Анализ Структуры И Антибиотикорезистентности Этиологически Значимых Возбудителей Хронической Инфекции Нижних Дыхательных Путей У Детей С Муковисцидозом, Проживающих В Г. Днепре

Ilchenko¹,

Fialkovska²,

Skriabinа³

2021

View full text Add to dashboard Cite

Муковісцидоз (МВ) залишається одним із найтяжчих спадкових хронічних поліорганних захворювань. В Україні дотепер існує проблема несвоєчасної діагностики МВ, що призводить до більш тяжкого перебігу захворювання, значного зниження якості й Êë³í³÷íà ïåä³àòð³ÿ / Clinical Pediatrics тривалості життя [1, 2]. Хронічне інфекційне запалення нижніх дихальних шляхів, що формується на основі генетичного дефекту вже в перші роки життя, є ключовим фактором у хворих на МВ та визначає прогноз захворювання [3]. Спектр мікроорганізмів, що ідентифікуються з нижніх дихальних шляхів, є досить

show abstract

Section: аналіз струêтури та антибіотиêорезистентності етіологічно знunclassified

Анализ Структуры И Антибиотикорезистентности Этиологически Значимых Возбудителей Хронической Инфекции Нижних Дыхательных Путей У Детей С Муковисцидозом, Проживающих В Г. Днепре

Ilchenko¹,

Fialkovska²,

Skriabinа³

2021

View full text Add to dashboard Cite

show abstract

“…Выявление особенностей персистенции основных возбудителей в легких больных МВ необходимо не только для выработки тактики лечения больных, но и для выяснения ряда важных вопросов эпидемиологии и микробиологии хронической инфекции легких у больных МВ. Показано, что выяснение данных вопросов возможно только на основе точной и своевременной идентификации возбудителей, которая имеет существенное значение для обеспечения своевременного начала лечения соответствующими антимикробными препаратами (АМП) (для элиминации бактериальных патогенов) и организации надлежащего инфекционного контроля (для профилактики распространения патогенных микроорганизмов среди больных МВ) [3]. С помощью разработанного алгоритма микробиологической диагностики хронической инфекции легких у больных МВ [4] были исследованы эпидемиологические особенности хронической инфекции легких, вызванной основными возбудителями: S. aureus, P. aeruginosa, B. cepacia complex и Achromobacter spp.…”

Section: Introductionunclassified

Epidemiological significance of genome variations in Pseudomonas aeruginosa causing chronic lung infection in patients with cystic fibrosis

Shaginyan

Avetisyan

Chernukha

et al. 2019

CMAC

View full text Add to dashboard Cite

Objective. To present the data on the main mechanism of molecular variation in P. aeruginosa causing chronic lung infection in patients with cystic fibrosis. Materials and Methods. A total of 1800 throat swabs and sputum samples from cystic fibrosis patients were included in the study over the 10-year period. P. aeruginosa isolates were primarily identified by the biochemical method using the API 20NE test strips (bioMerieux, France). Antimicrobial susceptibility testing was performed by disc diffusion method. Genotyping was conducted by RAPD-PCR and MLST. Whole genome sequencing of three typical P. aeruginosa isolates was performed on an Ion PGM Torrent platform with Ion Sequencing Kit and 316v1 chips (Life Technologies Thermo Fisher, US) according to the manufacturer’s protocol. The RAST web application was used for initial annotation. Results. There were three main variants of the pathogen variability found: population heterogeneity, pathogen microevolution, and replacement by another genotype of the same species. The variation of the pathogen’s genome is due to the acquisition of mobile genetic elements (plasmids), mutations in the chromosomal genes responsible for antibiotic resistance, bacterial viability and survival during persistence in a host, and changes in the prophage regions of the pathogen. Conclusions. Epidemiological significance of the molecular mechanisms of pathogen variation is primarily due to the ability of strains to form epidemiologically significant clone. This requires control measures aimed to limit emergence and distribution of such clones to be developed.

show abstract

Inhalation of antibiotics in the treatment of bronchopulmonal infection

Gembitskaya

Kharitonov²,

Chermensky³

et al. 2022

Bulletin of the Russian Military Medical Academy

View full text Add to dashboard Cite

An analysis of the current treatment protocol for lower respiratory tract infection using inhaled antibiotics is presented. Information about the pathophysiology and features of pathogens of bronchopulmonary infection in patients suffering from cystic fibrosis, nosocomial pneumonia, chronic obstructive pulmonary disease, and bronchiectasis of various etiologies is considered. The advantages and applications of inhaled antibiotics in the treatment of this category of patients are discussed. It has been established that acute and chronic infectious diseases of the lower respiratory tract are often the cause of severe human diseases and one of the leading causes of infectious mortality worldwide. Early initiation of adequate antibiotic therapy, especially in patients with a tendency to develop chronic inflammation, improves disease prognosis. However, mortality and the resistance of pathogens in this category of patients remain high. Traditional oral or parenteral antibiotic therapy does not achieve bactericidal concentrations in the lungs. Increasing dosages and combining antibiotics increases the likelihood of toxicity, superinfection, and resistance and causes undesirable side effects. Inhalation of antibiotics allows the delivery of higher concentrations directly to the lesion, thereby affecting the causative agents of the infectious process effectively while minimizing potential systemic toxicity. The large surface area of the alveoli and the thin epithelial layer provide a favorable environment for the deposition of inhaled drugs. Acute and chronic gram-negative bronchial infection caused by certain types of opportunistic microorganisms causes chronic inflammation, which leads to airway remodeling, damage to local defense mechanisms, further persistence of respiratory pathogens, and the formation of antibiotic resistance. In these cases, the use of inhaled forms of antibiotics has significant advantages in terms of effectiveness, stabilizing lung function and reducing the frequency of hospitalization, which improves quality of life and the need for systemic antibiotic therapy, reduces the risk of side effects, and reduces the cost of treatment. The results of the work can be useful for both therapists and pulmonologists.

show abstract

Epidemiological Features of Chronic Lung Infection in Patients with Cystic Fibrosis

Cited by 6 publications

References 4 publications

Epidemiological significance of genome variations in Pseudomonas aeruginosa causing chronic lung infection in patients with cystic fibrosis

Inhalation of antibiotics in the treatment of bronchopulmonal infection

Contact Info

Product

Resources

About