Epidemiological study of severe cutaneous adverse drug reactions in a city district of China

Li, LF; C, Ma

doi:10.1111/j.1365-2230.2006.02185.x

Cited by 73 publications

(85 citation statements)

References 15 publications

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“…10,11 However, the exact reason for this phenomenon is yet to be determined. 3 In this study, the Malay ethnic group contributed the highest number of ACDRs as they form the ethnic majority. Most patients with ACDR to took 1 to 5 concurrent drugs (27.6%) while about 11.2% took more than 6 drugs.…”

Section: Discussionmentioning

confidence: 99%

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Common adverse cutaneous drug reaction patterns and the causative drugs in Malaysia

Talib¹,

Leelavathi

Hamzah

2015

South African Family Practice

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Background:Patients with adverse cutaneous drug reactions (ACDRs) are frequently referred from primary care to tertiary centres for further management. This causes a loss of information regarding ACDRs as these patients discontinue primary care follow-up upon referral to tertiary care. The aim of this study is to determine the prevalence and characteristics of ACDR, and to use this valuable information to enhance awareness of primary care physicians regarding this condition. Method: A retrospective cross-sectional study on ACDR was done at the Dermatology Clinic, Kuala Lumpur General Hospital from January 2009 to December 2010. Results: The prevalence of ACDR was 0.2%. The majority of patients (71.6%) were below 59 years of age. ACDR commonly (55.2%) occurs within hours to days of drug ingestion and is of mild to moderate severity (74.6%). About 27.6% of affected patients took 1 to 5 drugs concurrently. Common cutaneous manifestation of ACDR includes maculopapular rash (22.4%) and Stevens-Johnson syndrome (SJS, 9.7%). Antibiotics (36.6%), traditional and complementary medicine (TCM, 17.9%) and analgesics (13.4%) were the most frequent agents responsible for ACDR. Conclusion:The prevalence of ACDR in this study is low and the majority were of mild to moderate severity. The most common cutaneous manifestation was a maculopapular reaction and Stevens-Johnson syndrome. Antibiotics were the commonest causative agent for ACDR followed by traditional and complementary medicine and analgesics. Patients presenting with cutaneous disorders in primary care should be assessed for possible ACDR. A detailed drug history, time of initiation and duration of drug consumption are all valuable information required for an accurate diagnosis and proper evaluation of ACDR. It is hoped that the findings of this study will facilitate early recognition of ACDR followed by identification and elimination of any possible offending drugs that may be prescribed in primary care practice.

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Section: Discussionmentioning

confidence: 99%

“…1 The prevalence of ACDR is about 0.16 to 1.35%. 2,3 However, this may be a deceptively low figure secondary to under-reporting. Data on ACDR are usually based on reporting by physicians and pharmacists.…”

Section: Introductionmentioning

confidence: 99%

Common adverse cutaneous drug reaction patterns and the causative drugs in Malaysia

Talib¹,

Leelavathi

Hamzah

2015

South African Family Practice

View full text Add to dashboard Cite

show abstract

“…16,17 The most common type of ADRs in our study was FDE (46.66%) followed by EM (16.66%), SJS (16.66%), Bullous FDE (6.66%), druginduced urticaria (3.33%), DRESS syndrome (3.33%), linchenoid drug eruption (3.33%) and TEN (3.33%). Previous studies also suggest FDE as the most common type of cutaneous ADRs.…”

Section: 12-15mentioning

confidence: 98%

Drug-induced cutaneous adverse drug reactions in dermatology in Dr. B.R. Ambedkar Medical College

Bai¹,

Padma²,

Mohan

et al. 2014

Int J Basic Clin Pharmacol

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“…16,[22][23][24][25] SJS and TEN are severe cutaneous adverse reactions (SCAR). [26][27][28][29][30][31][32][33][34] Epidermal detachment below 10% is defined as SJS, whereas it is considered TEN above 30% [35,36]. Epidermal detachment between 10% and 30% defines transitional SJS/TEN.…”

Section: Introductionmentioning

confidence: 99%

Genetic and immune predictors for hypersensitivity syndrome to antiepileptic drugs

Neuman

Cohen

Nanau

et al. 2012

Translational Research

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Epidemiological study of severe cutaneous adverse drug reactions in a city district of China

Abstract: These results confirm the relatively low incidence of SCADRs in China. Antibiotics, anticonvulsants and TCM are the most common causative drugs.

Cited by 73 publications

References 15 publications

Common adverse cutaneous drug reaction patterns and the causative drugs in Malaysia

Common adverse cutaneous drug reaction patterns and the causative drugs in Malaysia

Drug-induced cutaneous adverse drug reactions in dermatology in Dr. B.R. Ambedkar Medical College

Genetic and immune predictors for hypersensitivity syndrome to antiepileptic drugs

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