Epidemiological Surveillance of P and G Genotypes of Group A Rotavirus Detected from Diarrheic Patients in Daejeon Region

박선경,; 허영선,; 빙선혜,; 천두성,; 초가기,; 전무형,

doi:10.4167/jbv.2007.37.3.169

Cited by 4 publications

(1 citation statement)

References 28 publications

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“…Among them, G1P[8] was the most prevalent strain. According to recent studies in South Korea, The G1P[8] genotype prevalence rate was 33.1% and 53.9% [Park et al, 2007, Kim et al, 2009].…”

Section: Discussionmentioning

confidence: 99%

Full genomic analysis of a human rotavirus G1P[8] strain isolated in South Korea

Cho

Jheong

Lee

et al. 2012

Journal of Medical Virology

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A rotavirus G1P[8] strain C1-81 was isolated from a 5-month-old female infant admitted to hospital with fever and severe diarrhea in Incheon, South Korea. To investigate its full genomic relatedness and its group, the full genome of strain C1-81 was determined. Based on a full genome classification system, C1-81 was shown to possess the typical Wa-like genotype constellation: G1-P[8]-I1-R1-C1-M1-A1-N1-T1-E1-H1. On the basis of sequence similarities, the strain was shown to be the closest related strain to contemporary human rotavirus strains with recent strains isolated in Asia. This C1-81 strain showed the highest degree of nucleic acid similarity (98.8% and 97%) to G1 B4633-03 and P[8] (Thai-1604 and Dhaka8-02), respectively. This is the first report that group A rotavirus was analyzed with G1P[8] in South Korea. The study of the complete genome of the virus will help understanding of the evolution of rotavirus.

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“…Among them, G1P[8] was the most prevalent strain. According to recent studies in South Korea, The G1P[8] genotype prevalence rate was 33.1% and 53.9% [Park et al, 2007, Kim et al, 2009].…”

Section: Discussionmentioning

confidence: 99%

Full genomic analysis of a human rotavirus G1P[8] strain isolated in South Korea

Cho

Jheong

Lee

et al. 2012

Journal of Medical Virology

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Isolation and Characterization of G9 Human Rotaviruses

Lee

Kim

Lee³

et al. 2007

J Bacteriol Virol

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Group A rotaviruses are the most common causes of gastroenteritis among infants and young children. The outer capsid layer of the virus is composed of two structural proteins, VP4 and VP7, and they play important roles in protection by eliciting neutralization antibodies. Group A rotaviruses are subdivided into distinct G and P serotypes according to the antigenic differences of the VP7 and VP4, respectively. Rotavirus G9 serotype was thought to be the fifth most common serotype circulating among the population worldwide. In this study, G9 human rotaviruses (HRV) were isolated from fecal samples using MA104 cells and characterized. Characteristic cytopathic effects of rotavirus were observed and rotaviral antigens were confirmed by indirect immunofluorescence antibody test in MA104 cells inoculated with isolated HRV strains. The nucleotide sequences of the VP7 gene of Korean G9 HRV isolated in this study were determined and compared with those of other recent and prototype G9 rotavirus strains from other parts of the world. Also, the nucleotide sequences of VP4 and NSP4 gene of Korean G9 HRV were determined and compared with those of other rotavirus strains from other countries. The results showed that the Korean HRV isolates belong to a G9, P [8] and NSP4 B genotype. The Korean G9 HRV isolates and their nucleotide sequence data would be usefully applied for the vaccine development of HRV in the near future.

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Distribution of Group A Rotavirus Genotypes Circulating in Gwangju, Korea

Kim

Cheon²,

Jeong³

et al. 2009

J Bacteriol Virol

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To determine the distribution of rotavirus strain genotypes in Gwangju, Korea, we performed reverse-transcription polymerase chain reaction and nucleotide sequencing analysis using the 115 rotavirus EIA positive stool specimens collected from December 2006 through April 2007. The most predominant genotype was confirmed as G1P[8] (53.9%), followed by G3P[8] (29.6%), G4P[6] (8.7%), G2P[4] (4.3%) and G9P [8] (1.7%). A special attention is drawn to the unusual findings of the genotypes G11P[25] and G12P [9] during this study period. In order to investigate the phylogenetic relationships among the same or different genotypes, the nucleotide sequences of rotavirus circulating in Korea and the foreign countries were analyzed using MegAlign and Clustal X programme. The G11P [25] strain identified in this study showed the highest nucleic acid similarity with G11 /CUK1 /2006 /Korea (99.2%) and P[25] /Dhaka /2001 /BGD (98.7%). Meanwhile, the G12P[9] strain detected in this study shared 99.4~99.5% nucleotide homology with the reference strain G12P[9] /CP1030 /2004 /Japan. This incidence of new rotavirus genotypes in our area illustrates the large diversity of rotavirus strains found worldwide. Therefore, the epidemiological surveillance of rotavirus may need to be continued in a wide geographic area.

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Epidemiological Surveillance of P and G Genotypes of Group A Rotavirus Detected from Diarrheic Patients in Daejeon Region

Cited by 4 publications

References 28 publications

Full genomic analysis of a human rotavirus G1P[8] strain isolated in South Korea

Full genomic analysis of a human rotavirus G1P[8] strain isolated in South Korea

Isolation and Characterization of G9 Human Rotaviruses

Distribution of Group A Rotavirus Genotypes Circulating in Gwangju, Korea

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