Epidemiology and Genetic Diversity of Methicillin-ResistantStaphylococcus aureusStrains in Residential Care Homes for Elderly Persons in Hong Kong

Abstract

This study documented the emergence of SCCmec types IV and V among genetically diverse MRSA strains in residential care homes for elderly persons in Hong Kong.

A novel sequence-based coa genotyping method to discriminate nosocomial methicillin-resistant Staphylococcus aureus isolates

“…There were 74 SCCmec type III and 14 SCCmec type II isolates detected in this study. SCCmec type III is the prevalent SCCmec type of MRSA clinical strains in China [19]. Antibiogram analysis showed that overall, the type II and type III isolates demonstrated resistance to more antimicrobials than the type IV isolates.…”

Epidemiology ofStaphylococcus aureusColonization in Nursing Home Residents

“…In general, nursing home residents are colonized with hospital-acquired MRSA, typically SCC mec II. However, reports of CA-MRSA in nursing homes are slowly emerging [25][26][27][28][29]. In San Francisco, California, 12 (3.8%) of 318 CA-MRSA clinical isolates originated from nursing homes [25].…”

“…A cluster of infections due to SCCmec V MRSA was noted in 5 of 76 residents in a nursing home in Finland [29], and another nursing home in Germany reported that 7.6% of 197 residents were found to be colonized with PVL-containing MRSA strains [28]. A study of 949 residents in residential and continuum care facilities in Hong Kong noted that 23 (2.4%) were colonized with SCC mec IV or V MRSA strains [27]. In our study, 8 MRSA-colonized residents (9%) were colonized with SCCmec IV strains, including 2 residents who were colonized with PVLpositive strains, suggesting spread of CA-MRSA into southeastern Michigan nursing homes.…”

Vancomycin MIC creep in MRSA isolates from 1997 to 2008 in a healthcare region in Hong Kong

“…Multiplex PCRbased accessory gene regulator (agr) grouping was performed using the primer sets for agr groups IeIV. 11,12 Multilocus sequence typing (MLST) was performed on representative strains for each unique spa type and agr group combination. Strains with the same spa type and agr group results were used to infer MRSA clones.…”