Epidemiology and the Genetics of Psoriasis.

Jt, Elder; Rp, Nair; Jj, Voorhees

doi:10.1111/1523-1747.ep12386091

Cited by 60 publications

(42 citation statements)

References 38 publications

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“…In 70% of monozygotic twins, psoriasis develops concomitantly. Probability of psoriasis occurrence reaches for 70% when both parents are affected in comparison to 1-4% for the general human population [4][5][6]. The risk of psoriasis development is higher when the father is affected or is a psoriasis susceptibility gene carrier.…”

Section: Introductionmentioning

confidence: 97%

“…The risk of psoriasis development is higher when the father is affected or is a psoriasis susceptibility gene carrier. This phenomenon is called "genomic imprinting" [5,7].…”

Section: Introductionmentioning

confidence: 99%

“…Some researchers pointed out at autosomal dominant mode of inheritance with 60% of penetrance [4,5,8], while others multigenic and multifactorial mode of inheritance with environmental factors such as mechanical traumas, dietary factors, infections, psychological stressors, drugs (including lithium, antimalarials, betablockers, NSAiD, salicylates) [4,5,[9][10][11][12][13][14].…”

Section: Introductionmentioning

confidence: 99%

“…HLA-B13, -B17, -B39, -B57, -Cw6 (the most frequently observed), -Cw7 and class II HLA namely -DR4, DR7 (the most frequently encountered), -DR55 [4,5,[16][17][18][19]. HLA-Cw6 positive individuals suffer more frequently from psoriasis than their HLA-Cw6 negative siblings.…”

Section: Introductionmentioning

confidence: 99%

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Genes and structure of selected cytokines involved in pathogenesis of psoriasis.

Pietrzak

Zalewska²,

Chodorowska³

et al. 2008

Folia Histochem Cytobiol.

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Psoriasis is a common skin disease involving 1-4% of human population worldwide, of strong genetic background. The following cytokines are directly involved in psoriasis: TNF, IL-1, IL-2, IL-6, IL-7, IL-8, IL-15, IL-18, IL-19, IL-20, IL-23 whereas IL-4, IL-10, IL-12 as well as IL-11, IL-17 and IFN-gamma are rather indirectly engaged. This work is a review of some genetic factors and structure of selected cytokines and receptors and their genes location.

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Section: Introductionmentioning

confidence: 97%

“…The risk of psoriasis development is higher when the father is affected or is a psoriasis susceptibility gene carrier. This phenomenon is called "genomic imprinting" [5,7].…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Genes and structure of selected cytokines involved in pathogenesis of psoriasis.

Pietrzak

Zalewska²,

Chodorowska³

et al. 2008

Folia Histochem Cytobiol.

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“…5,6 Alguns estudos populacionais mostraram que a incidência da psoríase está aumentada em familiares de primeiro e segundo grau e em gémeos monozigóticos, em que atinge concordância de 70%, realçando a base genética na etiologia da doença. 7 …”

Section: Introductionunclassified

Interleucina-17 como Alvo Terapêutico na Psoríase

Torres

Filipe

2014

Acta Med Port

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RESUMOA psoríase é uma doença crónica, inflamatória, imunomediada que afecta cerca de 1-3% da população geral. O avanço no conhecimento da patogénese da psoríase levou ao desenvolvimento de novos fármacos direccionados para vias imunitárias mais específicas que os existentes. A IL-17 e os linfócitos Th17 têm um importante papel na patogénese de várias doenças auto-imunes e imunomediadas, incluindo a psoríase. A IL-17A é uma citocina pró-inflamatória, produzida pelos linfócitos Th17 juntamente com outras citocinas efetoras, como a IL-17F e IL-22. Esta citocina é igualmente expressa por outras células do sistema imune inato, incluíndo os mastócitos, neutrófilos e células dendríticas, todas elas encontradas nas lesões de psoríase. Por esta razão a IL-17 surgiu como um alvo terapêutico potencial. Vários agentes que inibem a IL-17 estão em desenvolvimento e os resultados clínicos preliminares são bastante promissores, confirmando a importância da IL-17 na fisiopatologia da psoríase. A intervenção selectiva no sistema imune desta nova classe de agentes biotecnológicos, torna-os uma abordagem terapêutica interessante no controlo de doenças auto-imunes e imunomediadas, como na psoríase. Num futuro próximo, estas novas terapêuticas poderão constituir uma alternativa válida aos agentes biológicos actualmente disponíveis. Palavras-chave: Anticorpos Monoclonais; Psoríase; Interleucina-17; Secukinumab; Ixekizumab; Brodalumab; Portugal. ABSTRACTPsoriasis is a chronic, immune-mediated inflammatory disease that affects up to 1-3% of the general population. An advanced understanding of the immune-pathogenesis of psoriasis has led to the development of new drugs that refine existing treatments or target novel molecular and immunologic pathways. IL-17 and Th17 cells play an important role in the pathogenesis of several autoimmune and immune-mediated disorders, including psoriasis. IL-17A, a pro-inflammatory cytokine, is produced by Th17 cells along with other effector cytokines, such as IL-17F an IL-22, but it is also expressed by other cells of the innate immune system, including mast cells, neutrophils or dendritic cells, that are found in psoriatic lesions. For this reason IL-17 has emerged as an attractive therapeutic target. Agents that inhibit IL-17 are in development and preliminary clinical results are promising, confirming the importance of IL-17 in psoriasis pathophysiology. Their selective intervention in the immune system makes them an attractive therapeutic approach to autoimmune diseases, particularly psoriasis, being possible that in the near future these novel therapies could be a valid alternative for currently available biologic agents. Keywords: Antibodies, Monoclonal; Psoriasis; Interleukine-17; Secukinumab; Ixekizumab; Brodalumab; Portugal. INTRODUÇÃOA psoríase é uma patologia relevante na prática clínica quer pela sua frequência quer pelo seu quadro clínico, que varia desde uma doença cutânea ligeira a uma doença multissistémica, grave e incapacitante.É uma doença crónica, inflamatória, imunomediada, com uma ...

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Cell kinetic characterization of cultured human keratinocytes from normal and psoriatic individuals

et al. 1996

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Psoriasis is a chronic skin disease characterized by epidermal hyperproliferation, disturbed differentiation, and inflammation. It is still a matter of debate whether the pathogenesis of psoriasis is based on immunological mechanisms, on defec tive growth control mechanisms, or possibly on a combination of both. Several in vivo cell biological differences between psoriatic lesional epidermis and normal epidermis have been reported. However, it is not clear whether these changes are causal or consequential. In case that keratinocytes from psoriatic patients have genetically determined deficiencies or polymorphisms with respect to autocrine growth regulation and the response to inflammatory cytokines, we hypothesize that these differences should be maintained in culture. Here we have started a systematic comparison of first passage keratinocytes cultured from normal skin and uninvolved psoriatic skin to address the question whether there are intrinsic differences in basic cell cycle parameters. In an established, defined culture system using keratinocyte growth medium (KGM) we have determined: (i) cell cycle parameters of exponentially growing keratinocytes, (ii) induction of quies cence by transforming growth factor (Jj (TGF-p,), and (iii) restimulation from the Go-phase of the cell cycle. Bivariate analysis of lodo-deoxyuridine incorporation and relative DNA content was performed by flow cytometry. Within the limita tions of this model no gross differences were found between normal and psoriatic keratinocytes with respect to S-phase duration (Ts), total cell cycle duration (Tc), responsiveness to TGF-fi, and the kinetics for recruitment from G 0. In psoriatic keratinocytes we found a lower amount of cells in S-phase and a shorter duration of G w compared to normal keratinocytes. The methodology developed here provides us with a model for further studies on differences between normal and psoriatic keratinocytes in their response to immunological and inflammatory me diators,

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Epidemiology and the Genetics of Psoriasis.

Cited by 60 publications

References 38 publications

Genes and structure of selected cytokines involved in pathogenesis of psoriasis.

Genes and structure of selected cytokines involved in pathogenesis of psoriasis.

Interleucina-17 como Alvo Terapêutico na Psoríase

Cell kinetic characterization of cultured human keratinocytes from normal and psoriatic individuals

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