2000
DOI: 10.2307/3454408
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Epidemiology of Fine Particulate Air Pollution and Human Health: Biologic Mechanisms and Who's at Risk?

Abstract: This article briefly summarizes the epidemiology of the health effects of fine particulate air pollution, provides an early, somewhat speculative, discussion of the contribution of epidemiology to evaluating biologic mechanisms, and evaluates who's at risk or is susceptible to adverse health effects. Based on preliminary epidemiologic evidence, it is speculated that a systemic response to fine particle-induced pulmonary inflammation, including cytokine release and altered cardiac autonomic function, may be par… Show more

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Cited by 432 publications
(130 citation statements)
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“…Pollutants of major public health concern include particulate matter (PM 10 and PM 2.5 ) and gases such as NOx, SO 2 , O 3 , and CO (Akhter et al, 2004;Begum et al, 2007) that have known severe health implications (Dockery and Pope 1994;Pope, 2000;Schwartz, 2001). Fine particles in the atmosphere have both anthropogenic and natural origins.…”
Section: Introductionmentioning
confidence: 98%
“…Pollutants of major public health concern include particulate matter (PM 10 and PM 2.5 ) and gases such as NOx, SO 2 , O 3 , and CO (Akhter et al, 2004;Begum et al, 2007) that have known severe health implications (Dockery and Pope 1994;Pope, 2000;Schwartz, 2001). Fine particles in the atmosphere have both anthropogenic and natural origins.…”
Section: Introductionmentioning
confidence: 98%
“…Epidemiological studies (e.g., Pope, 2000) and toxicological studies (e.g., Oberdörster, 2000) have associated urban PM pollution with carcinogenic and adverse respiratory and cardio-vascular effects. Recent reviews (EPA, 2009;HEI, 2013;WHO, 2013) concluded that adverse health effects are best linked to an exposure to PM with an equivalent aerodynamic diameter below 2.5 µm.…”
Section: Introductionmentioning
confidence: 99%
“…The majority of studies on the association between fine dust and health have focused on acute exposure via short-term assessments of health changes, including changes in the number of deaths and hospitalizations, and changes in pulmonary function in relation to short-term changes in the concentration of fine dust pollution. More than 40 studies have assessed the association between fine particles and respiratory symptoms or pulmonary function (Pope et al, 2000). Most of these studies focused on asthma and asthma exacerbations.…”
Section: Introductionmentioning
confidence: 99%