Epidemiology of insulin-dependent diabetes mellitus

Дедов, И И; Suntsov, Yu. I.; Сунцов, Ю. И.; Kudryakova, S. V.; Кудрякова, С. В.; Ryzhkova, S. G.

doi:10.14341/probl199844247-51

Cited by 4 publications

(2 citation statements)

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“…Распространенность ожирения в мире столь велика, что приобрела характер глобальной эпидемии. Наряду с ростом частоты ожирения отмечается увеличение распространенности и усугубление течения связанных с ним тяжелых соматических заболеваний [сахарный диабет 2 типа (CД2), артериальная гипертония (АГ), ишемическая болезнь сердца (ИБС), онкологические заболевания и другие], снижающих качество жизни и повышающих уровень смертности среди трудоспособного населения [1].…”

Section: Correction Of the Functional State Of The Renal Tubules коррunclassified

Study of the Functional State of the Proximal Renal Tubules in Patients with Asymptomatic Chronic Heart Failure in Dyslipidemia and its Correction with Simvastatin Treatment

Kopylov

2020

Racionalʹnaâ farmakoterapiâ v kardiologii

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Aim. To study indicators of epithelial dysfunction in the proximal renal tubules by determining the activity of organ-specific enzymes neutral α-glucosidase (NAG) and L-alanine aminopeptidase (LAAP), in patients with the initial stage of chronic heart failure in dyslipidemia, and the possibility of reducing with simvastatin.Material and methods. The study involved 90 subjects, who were divided into control and main groups. The control group consisted of 30 practically healthy individuals, the main group was divided into 2 subgroups: patients with stage I chronic heart failure (CHF) without type 2 diabetes mellitus (DM2) and patients with CHF with DM2. Patients of each of the main subgroups received simvastatin 20-40 mg/day in addition to treatment of the main pathology. The main group included patients with a total serum cholesterol level of more than 6.0 mmol/l, a BMI level of more than 30 kg/m2, and who had not previously taken statins. The exclusion criterion was a violation of the filtration capacity of the kidneys and the presence of gross dysfunction of organs and systems of the body. The functional state of the proximal renal tubules was assessed by the concentration of NAG and LAAP in dialized urine.Results. Initially, the level of activity of renal enzymes in representatives of both major subgroups is higher than the group of practically healthy individuals. Taking simvastatin in the CHF without DM2 subgroup does not cause an increase in enzyme activity throughout the entire observation period, either at a daily dosage of 20 mg (NAG - 12.36±2.65 ncat/1 14.1±5.23 ncat/1 and after 3 and 6 months, LAAP - 9.4±1.62 and 11.2±2.99 ncat/1 after 3 and 6 months), or at a dosage of 40 mg/day (NAG - 30.47±3.85 and 26.2±6.75 ncat/1 after 3 and 6 months; LAAP -17.3±3.56 and 19.58±3.83 ncat/1 after 3 and 6 months). Taking simvastatin 20 mg/day in patients with CHF with DM 2 causes an increase in the NAG activity: 26.68±6.03 and 34.57±9.73 ncat/1 after 3 and 6 months). Taking simvastatin 40 mg/day increase both enzyme activity: NAG -34.3±8.7 and 46.94±9.02 ncat/1 after 3 and 6 months, LAAP - 17.08±5.81 and 22.41±4.89 ncat/1 after 3 and 6 months).Conclusion. The appointment of simvastatin in patients with dyslipidemia on the background of obesity is permissible in order to normalize lipid metabolism. Safe for the functional state of the proximal renal tubules, long-term administration of simvastatin, within the limits of medium-therapeutic dosages, is possible for patients without type 2 diabetes. Long-term use of simvastatin in patients with dyslipidemia on the background of type 2 diabetes mellitus has a negative effect on the epithelium of the proximal renal tubules, in the form of an increase in the activity of renal organ-specific enzymes, which indicates an increased dystrophy of the epithelium.

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Section: Correction Of the Functional State Of The Renal Tubules коррunclassified

Study of the Functional State of the Proximal Renal Tubules in Patients with Asymptomatic Chronic Heart Failure in Dyslipidemia and its Correction with Simvastatin Treatment

Kopylov

2020

Racionalʹnaâ farmakoterapiâ v kardiologii

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“…In particular, 20 HBOT sessions decreased fasting glucose by 21% and ameliorated glucose tolerance by 34%, suggesting that hyperbaric environment influences glucose metabolism, either by improving glucose uptake or glucose oxidation in the postprandial state (Vera‐Cruz et al., 2015). In type 1 diabetes (T1D), a study demonstrated enhanced residual insulin secretion as a result of hyperbaric oxygenation (Dedov, Lukich, Bol'shakova, Gitel, & Dreval, 1987).…”

Section: The Impact Of Hyperbaric Environment On Glucose Homeostasismentioning

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Into the deep blue sea: A review of the safety of recreational diving in people with diabetes mellitus

Koufakis

Karras

Mustafa

et al. 2019

European Journal of Sport Science

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People with diabetes, particularly those being insulin treated, have been for many years considered ineligible for diving, because of the high risk of adverse events. Blood glucose levels tend to decline during diving, probably because of changes in insulin requirements and resistance, due to increased physical activity and effects of hyperbaric environment on glucose tolerance. Strict adherence to safety protocols, in conjunction with optimal physical status, lack of diabetic complications (especially impaired awareness of hypoglycaemia) and satisfactory baseline glycaemic control, seem to minimise the risk of complications during diving. The integration of modern technology into diabetes management, providing potential for underwater continuous glucose monitoring, can be useful in optimising metabolic control before, during and after diving. Despite the significant progress been made on safety issues, there is still a need to implement the relevant recommendations into divers' everyday practice. Existing evidence is mainly derived from small studies and there is a wide heterogeneity in terms of study designs and explored outcomes, rendering the extraction of definitive conclusions challenging. The aim of this review is to present and critically evaluate available evidence, use of technology, and gaps in existing knowledge that deserve further evaluation by future studies.

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Nutrition and diabetes in the Asia–Pacific region with reference to cardiovascular disease

Wahlqvist

2001

Asia Pac J Clin Nutr

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In many parts of the Asia-Pacific region, diabetes prevalence is increasing and seems destined to become a major risk factor for cardiovascular disease. The phenomenon seems predicated on insulin resistance (IR), partly attributable to an early impact of abdominal (visceral) adiposity than in Caucasian populations. Food intake along with physical activity and emotional stress are all determinants of glycaemic status. The glycaemic index (GI) of foods indicates that a number of food factors other than glucose content are important for good glycaemic response to foods and meals. These include (i) low GI foods could also be ones low in fat, (ii) foods that have the lowest GI which include lentils, pasta, noodles, multigrain breads and some fruits (e.g. grapefruit, plums) and (iii) fruits are to be preferred to their juices. The nutritional management of diabetes is best served by counselling changes in a sociocultural context and step-wise fashion by negotiation rather than prescription. It needs to be accompanied by advice to engage in regular physical activity, both aerobic and strength training. The same concept applies to the prevention of abdominal adiposity and diabetes mellitus type II in the Asia-Pacific region, but with particular reference to protective regional food.

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Epidemiology of insulin-dependent diabetes mellitus

Cited by 4 publications

References 0 publications

Study of the Functional State of the Proximal Renal Tubules in Patients with Asymptomatic Chronic Heart Failure in Dyslipidemia and its Correction with Simvastatin Treatment

Study of the Functional State of the Proximal Renal Tubules in Patients with Asymptomatic Chronic Heart Failure in Dyslipidemia and its Correction with Simvastatin Treatment

Into the deep blue sea: A review of the safety of recreational diving in people with diabetes mellitus

Nutrition and diabetes in the Asia–Pacific region with reference to cardiovascular disease

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