The relation between serum uric acid level and cardiovascular risk factors is complex and has been investigated mainly in men. We examined the correlation between serum uric acid level and obesity, hypertension, dyslipidemia, and diabetes mellitus (DM) in both men and women of a screened cohort in Okinawa, Japan. A total of 9,914 individuals (6,163 men and 3,751 women ranging in age from 18 to 89 years) who were screened at Okinawa General Health Maintenance Association were subjects in this study. Hyperuricemia tality in individuals with ischemic heart disease (7), the specific role of serum uric acid in relation to cardiovascular disease remains unclear.The association between serum uric acid and other cardiovascular risk factors complicates the issue. Increased serum uric acid levels are often accompanied by obesity, dyslipidemia, and hypertension (8-11), all of which are associated with increased risk for cardiovascular disease. In Japan, there are reports suggesting a significant correlation between increased serum uric acid level and cardiovascular risk factors in large members of men, but not women (12). Okada et al. (13) showed a significant correlation between serum uric acid and cardiovascular risk factors, but the number of indi-