Epidermodysplasia verruciformis in a patient with HIV infection: no response to highly active antiretroviral therapy

Carré, Delphine; Dompmartin, Anne; Verneuil, Laurence; Verdon, Renaud; Comoz, F.; Brun, Emmanuel; Freymuth, F.; Leroy, D.

doi:10.1046/j.1365-4362.2003.01707_2.x

Cited by 30 publications

(24 citation statements)

References 20 publications

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“…Although in most cases clinical and histological features of the warts [17,42,43,46,47,48] and the associated HPV types [17,46,48] in immunosuppressed patients do not differ from those in the general population, rare cases of acquired EV-like eruption have been reported in immunosuppressed patients, including patients with organ transplants [15,16,17,18,19], lepromatous leprosy [49], Hodgkin lymphoma [20], systemic lupus erythematosus [21,22], human immunodeficiency virus infection [19,23,24,25,26,27,28,29,30,31,32,33,34,50,51], severe combined immune deficiency caused by γc or JAK3 deficiency after hemopoietic stem cell transplantation [35], and in the setting of graft-versus-host disease [36]. Treatment with biological agents may also increase the risk for HPV infections including acquired EV [52].…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, β-papillomaviruses may be commensals of the human skin and harmless for the general population, although their roles in the development of nonmelanoma skin cancers, particularly in immunosuppressed patients, have been suggested [12,13,14]. In addition, acquired EV-like eruption associated with β-papillomavirus infection has occasionally been described in immunosuppressed patients [15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36]. …”

Section: Introductionmentioning

confidence: 99%

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Epidermodysplasia-Verruciformis-Like Eruption Associated with Gamma-Papillomavirus Infection in a Patient with Adult T-Cell Leukemia

Kawai

Egawa²,

Kiyono³

et al. 2009

Dermatology

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Epidermodysplasia verruciformis (EV) is a genodermatosis characterized by widespread and persistent cutaneous lesions caused by β-papillomaviruses. Rare cases of acquired EV-like eruption associated with β-papillomavirus infection have been reported in immunosuppressed patients. We report a case of acquired EV-like eruption in an immunosuppressed patient with adult T-cell leukemia. The cutaneous lesions clinically resembled pityriasis versicolor and exhibited the typical histological features of EV, but in some areas of the same biopsy specimen characteristic homogeneous intracytoplasmic inclusion bodies were observed. Although β-papillomavirus was not detected by highly sensitive polymerase chain reaction, a putative novel type of γ-papillomavirus was identified. This is the first documentation of an association between EV-like eruption and γ-papillomavirus infection.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Epidermodysplasia-Verruciformis-Like Eruption Associated with Gamma-Papillomavirus Infection in a Patient with Adult T-Cell Leukemia

Kawai

Egawa²,

Kiyono³

et al. 2009

Dermatology

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“…Among these reported cases, less than 20 cases involve HIV. 12,[45][46][47][48][49][50][51][52][53][54] When EV is acquired by these immunocompromised individuals, as opposed to the typical autosomal recessive inheritance, it is often referred to as ''acquired EV.'' 54 Clinically, the lesions are indistinguishable from EV.…”

Section: Hivmentioning

confidence: 99%

Generalized verrucosis: A review of the associated diseases, evaluation, and treatments

Sri

Dubina

Kao

et al. 2012

Journal of the American Academy of Dermatology

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“…In some specialized hospital departments, HLUs account for up to 15% of all the ulcers treated [6] . Treatment of HLU remains a therapeutic challenge [7,8] .…”

Section: Introductionmentioning

confidence: 99%

Autologous Adipose Tissue Graft to Treat Hypertensive Leg Ulcer: A Pilot Study

Chopinaud

Labbé

Creveuil³

et al. 2017

Dermatology

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Background: Adipose tissue is an abundant source of mesenchymal stem cells, called adipose-derived stem cells, which have anti-inflammatory and trophic effects to enhance overall tissue repair. Objective: To determine the healing effects of autologous adipose tissue graft on hypertensive leg ulcers. Methods: Prospective pilot study in 1 French dermatology department. Ten patients with a hypertensive leg ulcer were enrolled from April 2013 to June 2015. The primary end point was the wound closure rate at each follow-up visit. The secondary end points were wound characteristics, pain assessment and adverse events. Results: One patient, the only smoker, was lost to follow-up at month 5 (M5). For the 9 non-smokers, wound surfaces constantly and significantly decreased: the median wound closure rate was 73.2% at M3 and 93.1% at M6, p < 0.001. The median wound closure rate of the 10 patients was 63.2% at M3, p < 0.001. Percentages of fibrin and necrosis decreased, granulation tissue increased significantly. Pain rapidly and significantly decreased. No recurrence or adverse event was observed. Conclusion: Our data suggest that autologous adipose tissue grafting induces pain relief and promotes wound healing with a good skin quality. Large prospective controlled randomized studies are required to confirm these results.

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Epidermodysplasia verruciformis in a patient with HIV infection: no response to highly active antiretroviral therapy

Cited by 30 publications

References 20 publications

Epidermodysplasia-Verruciformis-Like Eruption Associated with Gamma-Papillomavirus Infection in a Patient with Adult T-Cell Leukemia

Epidermodysplasia-Verruciformis-Like Eruption Associated with Gamma-Papillomavirus Infection in a Patient with Adult T-Cell Leukemia

Generalized verrucosis: A review of the associated diseases, evaluation, and treatments

Autologous Adipose Tissue Graft to Treat Hypertensive Leg Ulcer: A Pilot Study

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