Epigenetic Changes of the <i>ESR1</i> Gene in Breast Tissue of Healthy Women: A Missing Link with Breast Cancer Risk Factors?

Daraei, Abdolreza; Izadi, Pantea; Khorasani, Ghasemali; Nafissi, Nahid; Naghizadeh, Mohammad Mehdi; Younosi, Nasim; Meysamie, Alipasha; Mansoori, Yaser; Bastami, Milad; Bazzaz, Javad Tavakkoly

doi:10.1089/gtmb.2017.0028

Cited by 18 publications

(24 citation statements)

References 24 publications

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“…In this setting, premenopausal BC is influenced by adolescent, but not adult, body size with greater body mass associated with a reduction in BC risk . A possible explanation for the correlation of BMI and BC risk is that high BMI is associated with an increased level of circulatory estrogen, and, in combination with a decreased circulation of sex hormone binding globulin, may lead to a greater tissue availability of estrogen . On the other hand, the increased risk of BC associated with early menarche is also attributed, at least in part, to the lifetime exposure to estrogen .…”

Section: Resultsmentioning

confidence: 99%

Expression levels of breast cancer-relatedGAS5andLSINCT5lncRNAs in cancer-free breast tissue: Molecular associations with age at menarche and obesity

et al. 2018

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Long noncoding RNAs (lncRNAs) constitute a major class of the human transcriptome which play crucial roles in the key biological processes of both normal and malignant breast cells. Although the aberrant expression of lncRNAs has been well-documented in breast cancer (BC), little is currently known about the association between their expression levels in the breast tissue of healthy women and BC risk factors, especially the reproductive or demographic characteristics that are among the most well-known BC risk modifiers. This study was an attempt to investigate the correlation between the expression levels of 2 breast cancer-related lncRNAs, including GAS5 and LSINCT5, and reproductive and demographic characteristics in 145 normal breast tissues that were obtained from women without breast cancer undergoing cosmetic surgery. Total RNA was extracted from fresh normal breast tissues, and the expression level of target lncRNAs was quantified using real-time qPCR. Differences in the mean normalized gene expression among the subgroups of different variables were analyzed. The expression levels of both genes was lower in the overweight-obese (BMI ≥ 25) subgroup than that in the normal BMI (BMI < 25) subgroup (GAS5 P = .019, LSINCT5 P = .036). Moreover, the expression level of GAS5 was negatively correlated with BMI (r: -.170, P: .041). The expression level of GAS5 was higher in women with late menarche (>13 years) than that with early menarche (≤13 years; P = .017). These findings may assist to obtain insights into the molecular mechanisms through which the reproductive or obesity-related estrogen changes contribute to the breast carcinogenesis. In conclusion, this study presents the first evidence for the presence of a link between the lncRNA expression and the reproductive or obesity related factors in the breast tissue of healthy women.

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Section: Resultsmentioning

confidence: 99%

Expression levels of breast cancer-relatedGAS5andLSINCT5lncRNAs in cancer-free breast tissue: Molecular associations with age at menarche and obesity

et al. 2018

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“…Population‐based studies in BC patients suggest that obesity is associated with hypermethylation of several tumour suppressor genes including RARβ , ECAD , P16 (Tao et al, ), HIN1 (Krop et al, ), RASSF1A and BRCA1 (Naushad et al, ). Increased BMI is also associated with ESR1 hypermethylation (Daraei et al, ). There is a large gap in knowledge regarding the mechanisms linking obesity and hypermethylation of tumour suppressor genes in BC development.…”

Section: Discussionmentioning

confidence: 99%

“…RASSF1A and BRCA1 (Naushad et al, 2014). Increased BMI is also associated with ESR1 hypermethylation (Daraei et al, 2017). There is a large gap in knowledge regarding the mechanisms linking obesity and hypermethylation of tumour suppressor genes in BC development.…”

Section: Discussionmentioning

confidence: 99%

“…In contrast to obesity, increased exercise was associated with a decreased risk of BC, and meta-analyses have suggested that this may be due to a positive association between global CpG methylation and physical activity (Boyne et al, 2018) A methylation study of RARβ, E-cadherin 1 (ECAD) and P16 in (n = 803) breast tumour blocks from the Western New York Exposure and BC Study found that a greater WHR was associated with an increased probability (OR = 1.85) of hypermethylation of one or more of these genes (Tao et al, 2011). An analysis of non-malignant breast tissue from healthy women (n = 120) who had undergone cosmetic mammoplasty reported hypermethylation of ESR1 in obese women (BMI of ≥30 kgÁm −2 ) compared to both overweight (BMI of~25-29 kgÁm −2 ) and normal weight (BMI of <25 kgÁm −2 ; Daraei et al, 2017). ).…”

Section: Dietary Fat Obesity and Targeting Of Dna Methylation In Bcmentioning

confidence: 99%

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Dietary fat and obesity as modulators of breast cancer risk: Focus on DNA methylation

Donovan

Wren

Cenker

et al. 2020

British J Pharmacology

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Breast cancer (BC) is the most common cancer and second leading cause of cancer mortality in women worldwide. Validated biomarkers enhance efforts for early detection and treatment, which reduce the risk of mortality. Epigenetic signatures have been suggested as good biomarkers for early detection, prognosis and targeted therapy of BC. Here, we highlight studies documenting the modifying effects of dietary fatty acids and obesity on BC biomarkers associated with DNA methylation. We focus our analysis on changes elicited in writers of DNA methylation (i.e., DNA methyltransferases), global DNA methylation and gene‐specific DNA methylation. To provide context, we precede this discussion with a review of the available evidence for an association between BC incidence and both dietary fat consumption and obesity. We also include a review of well‐vetted BC biomarkers related to cytosine‐guanine dinucleotides methylation and how they influence BC risk, prognosis, tumour characteristics and response to treatment. Linked Articles This article is part of a themed section on The Pharmacology of Nutraceuticals. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v177.6/issuetoc

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“…The results of article identification starting in 2015-2019, there are 6 articles that need to be reviewed as risk factors for early menarche, namely: 1) Genoveva, M., D., P., (2015) with a study entitled "Consumption of Junk Food and Early Puberty", described that the consumption habits of junk food affect puberty early [15]. 2) Rummy, IZ, et al (2017), with a study entitled "Age of Menarche Associated with Nutritional Status, Food Consumption and Physical Activity", described risk factors for early menarche, namely nutritional status, fat intake, frequency of consumption of junk food and physical activity related to early menarche [16]. 3) Rizky, B., et al, (2017), with a study entitled "Factors Associated with Menarche Dini in adolescent girls in Medan 10 N. Middle School", described that behavior can be a risk factor for early menarche, namely the pattern good eating, good nutritional status, external stimuli such as pornography related to early menarche [17].…”

Section: B Breast Cancer Prevention Efforts Through Risk Factors Fomentioning

confidence: 99%

Early Menarche with Breast Cancer Awareness: A Literature Review

Djannah¹,

Solikhah²

2019

Proceedings of the 2019 Ahmad Dahlan International Conference Series on Pharmacy and Health Science (ADICS-PHS 2019)

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Breast cancer is a cancer with the second highest prevalence after cervical cancer in Indonesia. The cause of high cases of breast cancer can occur because of ignorance about the triggers of the causes of breast cancer. The development and growth of the breast is influenced by the hormones estrogen and progesterone for growth. One of these hormones, namely estrogen can trigger the initial cause of cancer. It is known that the incidence of girls in Indonesia experiences menarche at less than 12 years of age, so that socialization of breast cancer prevention behaviors in conjunction with early menarche is important. This study aims to review, analyze and compare the number of articles stating the presence or absence of early menarche relationships with breast cancer in order to become a public concern that early menarche is a risk factor for breast cancer, as well as prevention efforts through risk factors for early menarche, because early menarche is one risk factors for breast cancer are factors that cannot be changed. The design used is a review literature. The results of the study, based on literature studies from the PubMed, are articles from 2015-2019 that comparing the number of articles showed that there was a relationship between early menarche and breast cancer, namely 10 out of 12 articles (83.3%), compared to those showing no relationship, namely 2 articles from 12 articles (16.6 %). In conclusion there have been many studies that suggest a relationship between early menarche and breast cancer, so early menarche can be considered as a risk factor for breast cancer and several efforts to prevent breast cancer through menarche risk factors, especially a risky lifestyle, namely excessive fat intake media exposure for adults, lack of physical activity, use of hormonal contraception by mothers, and weight.

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Epigenetic Changes of the ESR1 Gene in Breast Tissue of Healthy Women: A Missing Link with Breast Cancer Risk Factors?

Cited by 18 publications

References 24 publications

Expression levels of breast cancer-relatedGAS5andLSINCT5lncRNAs in cancer-free breast tissue: Molecular associations with age at menarche and obesity

Expression levels of breast cancer-relatedGAS5andLSINCT5lncRNAs in cancer-free breast tissue: Molecular associations with age at menarche and obesity

Dietary fat and obesity as modulators of breast cancer risk: Focus on DNA methylation

Early Menarche with Breast Cancer Awareness: A Literature Review

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