Epigenetic inhibition assisted chemotherapeutic treatment of lung cancer based on artificial exosomes

Lin, Yinshan; Li, Songpei; Xiao, Zekuan; Chen, Sheng; Yang, Langyu; Peng, Qingsheng; Li, Huan; Fu, Jijun; Yu, Xiyong; Zhang, Lingmin

doi:10.1016/j.phrs.2021.105787

Cited by 24 publications

(13 citation statements)

References 26 publications

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“…Therefore, the driven force of MI might be mainly affected by the negative-charged MSNs. Previous reports indicated that the steric hindrance of the glycosylated domain produced the driving forces and guided the correct protein right-side-out orientation by the reduced energetic profile ( Hu et al, 2014 ; Lin et al, 2021 ). Herein, CMI showed similar zeta potential to MI after CCM coating.…”

Section: Resultsmentioning

confidence: 99%

“…Various cell types, including red blood cells (RBC) ( Dehaini et al, 2017 ; Kim et al, 2020 ), platelets ( Dehaini et al, 2017 ; Kunde and Wairkar, 2021 ), white blood cells ( Yaman et al, 2020 ), cancer cells ( Yang et al, 2018 ) and stem cells ( Defterali et al, 2016 ), have been coated with the nanoparticles ( Fang et al, 2018 ). In comparison with polymer coating, cell membranes coated with nanoparticles exhibited low immunogenicity and excellent homologous targeting ability ( Fang et al, 2018 ; Li et al, 2020 ; Lin et al, 2021 ; Peng et al, 2021 ). For cancer diagnosis and treatment, based on the homologous targeting ability, nanoparticles coated with the cancer cell membrane from homologous cells could efficiently deliver drugs and probes to the tumors ( Fang et al, 2018 ; Zhang L. et al, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

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Efficient Photoacoustic Imaging With Biomimetic Mesoporous Silica-Based Nanoparticles

Huang

Guan

Lin

et al. 2021

Front. Bioeng. Biotechnol.

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Indocyanine green (ICG), a near-infrared (NIR) fluorescent dye approved by the Food and Drug Administration (FDA), has been extensively used as a photoacoustic (PA) probe for PA imaging. However, its practical application is limited by poor photostability in water, rapid body clearance, and non-specificity. Herein, we fabricated a novel biomimetic nanoprobe by coating ICG-loaded mesoporous silica nanoparticles with the cancer cell membrane (namely, CMI) for PA imaging. This probe exhibited good dispersion, large loading efficiency, good biocompatibility, and homologous targeting ability to Hela cells in vitro. Furthermore, the in vivo and ex vivo PA imaging on Hela tumor-bearing nude mice demonstrated that CMI could accumulate in tumor tissue and display a superior PA imaging efficacy compared with free ICG. All these results demonstrated that CMI might be a promising contrast agent for PA imaging of cervical carcinoma.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Efficient Photoacoustic Imaging With Biomimetic Mesoporous Silica-Based Nanoparticles

Huang

Guan

Lin

et al. 2021

Front. Bioeng. Biotechnol.

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“…PDGP was mixed with the mBMSCs membrane at a weight ratio of 1:1, according to our previous work [ 17 , 18 ]. The mixture was sonicated for 5 min and extruded back and forth 15 times with a LiposoFast-Basic extruder (Avestin Inc., Ottawa, Canada) to obtain MPDGP.…”

Section: Methodsmentioning

confidence: 99%

“…Cell membrane-camouflaged nanoparticles have emerged as promising drug delivery systems [ 14 – 16 ]. The cell membrane coating endowed the nanoparticles with cell-like functions, which increased the circulating time of nanoparticles or conferred immunocompatibility and targeting capacity to the nanoparticles [ 17 , 18 ]. Inspired by cell membrane camouflage technology, we evaluated whether MSCs membrane-coated nanoparticles can serve as an efficient drug delivery system for treating pneumonia.…”

Section: Introductionmentioning

confidence: 99%

Artificial stem cells mediated inflammation-tropic delivery of antiviral drugs for pneumonia treatment

Qin

Chen

et al. 2022

J Nanobiotechnol

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Background Cytomegalovirus (CMV) pneumonia is a major cause of morbidity and mortality in immunodeficiency individuals, including transplant recipients and Acquired Immune Deficiency Syndrome patients. Antiviral drugs ganciclovir (GCV) and phosphonoformate (PFA) are first-line agents for pneumonia caused by herpesvirus infection. However, the therapy suffers from various limitations such as low efficiency, drug resistance, toxicity, and lack of specificity. Methods The antiviral drugs GCV and PFA were loaded into the pH-responsive nanoparticles fabricated by poly(lactic-co-glycolic acid) (PLGA) and 1,2-dioleoyl-3-trimethylammonium-propane (DOTAP), and further coated with cell membranes derived from bone marrow mesenchymal stem cells to form artificial stem cells, namely MPDGP. We evaluated the viral suppression effects of MPDGP in vitro and in vivo. Results MPDGP showed significant inflammation tropism and efficient suppression of viral replication and virus infection-associated inflammation in the CMV-induced pneumonia model. The synergistic effects of the combination of viral DNA elongation inhibitor GCV and viral DNA polymerase inhibitor PFA on suppressing the inflammation efficiently. Conclusion The present study develops a novel therapeutic intervention using artificial stem cells to deliver antiviral drugs at inflammatory sites, which shows great potential for the targeted treatment of pneumonia. To our best knowledge, we are the first to fabricate this kind of artificial stem cell to deliver antiviral drugs for pneumonia treatment. Graphical Abstract

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“…A complex artificial vesicular structure consisting of nanoparticles, mesoporous silica and macrophage-derived EV membranes was loaded with the HDAC inhibitor SAHA and observed to reduce lung cancer progression more efficiently than the nascent compound [ 121 ]. This effect was attributed to the increased homing of artificial vesicles due to their integrin α4β1 content originated from the macrophage EVs [ 121 , 122 ]. This approach may be harnessed in case of UM, in particular MUM with liver metastases, given that EVs are taken up by the liver rapidly and that promising results have been published with EVs in other hepatic carcinomas [ 123 ].…”

Section: Future Perspectivesmentioning

confidence: 99%

Evaluation of the Therapeutic Potential of Histone Deacetylase 6 Inhibitors for Primary and Metastatic Uveal Melanoma

Sundaramurthi

Giricz

Kennedy

2022

IJMS

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Patients diagnosed with metastatic uveal melanoma (MUM) have a poor survival prognosis. Unfortunately for this rare disease, there is no known cure and suitable therapeutic options are limited. HDAC6 inhibitors (HDAC6i) are currently in clinical trials for other cancers and show potential beneficial effects against tumor cell survival in vitro and in vivo. In MUM cells, HDAC6i show an anti-proliferative effect in vitro and in preclinical xenograft models. The use of HDAC6 inhibitors as a treatment option for MUM should be explored further. Therefore, this review discusses (1) what is known about HDAC6i in MUM and (2) whether HDAC6 inhibitors offer a potential therapeutic option for MUM.

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Epigenetic inhibition assisted chemotherapeutic treatment of lung cancer based on artificial exosomes

Cited by 24 publications

References 26 publications

Efficient Photoacoustic Imaging With Biomimetic Mesoporous Silica-Based Nanoparticles

Efficient Photoacoustic Imaging With Biomimetic Mesoporous Silica-Based Nanoparticles

Artificial stem cells mediated inflammation-tropic delivery of antiviral drugs for pneumonia treatment

Evaluation of the Therapeutic Potential of Histone Deacetylase 6 Inhibitors for Primary and Metastatic Uveal Melanoma

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