Epigenetics of Cutaneous Sarcoma

Mashima, Emi; Sawada, Yu

doi:10.3390/ijms23010422

Cited by 11 publications

(6 citation statements)

References 122 publications

(130 reference statements)

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“…As the mechanism, chidamide could regulate PD-L1 transcription by affecting the transcription factor STAT1 that binds to the promoter site of PD-L1 [76]. This HDAC inhibitor effect seems to be a disadvantage for the anti-tumor immune response; therefore, a single HDAC inhibitor treatment might not obtain enough therapeutic potency against cancers, as shown in previous studies [77].…”

Section: Hdac Inhibitor Enhances Pd-l1 Expression In Tumorsmentioning

confidence: 95%

Epigenetic Modification of PD-1/PD-L1-Mediated Cancer Immunotherapy against Melanoma

Nanamori

Sawada

2022

IJMS

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Malignant melanoma is one of the representative skin cancers with unfavorable clinical behavior. Immunotherapy is currently used for the treatment, and it dramatically improves clinical outcomes in patients with advanced malignant melanoma. On the other hand, not all these patients can obtain therapeutic efficacy. To overcome this limitation of current immunotherapy, epigenetic modification is a highlighted issue for clinicians. Epigenetic modification is involved in various physiological and pathological conditions in the skin. Recent studies identified that skin cancer, especially malignant melanoma, has advantages in tumor development, indicating that epigenetic manipulation for regulation of gene expression in the tumor can be expected to result in additional therapeutic efficacy during immunotherapy. In this review, we focus on the detailed molecular mechanism of epigenetic modification in immunotherapy, especially anti-PD-1/PD-L1 antibody treatment for malignant melanoma.

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Section: Hdac Inhibitor Enhances Pd-l1 Expression In Tumorsmentioning

confidence: 95%

Epigenetic Modification of PD-1/PD-L1-Mediated Cancer Immunotherapy against Melanoma

Nanamori

Sawada

2022

IJMS

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“…There is still more to learn about how sirtuins and fibroblast function relate to other kinds of skin cancer, like dermatofibrosarcoma protuberans (DFSP). DFSP is a cutaneous sarcoma derived from fibroblast and multiple studies have linked its function to EZH2-mediated histone methylation, and COL1A1-PDGFB translocation ( 134 , 135 ). As mentioned previously, SIRT6 is influenced through mRNA express of COL1A1 activity ( 77 , 78 ).…”

Section: Wound Healingmentioning

confidence: 99%

The role of sirtuins in dermal fibroblast function

et al. 2023

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The sirtuins are a family of seven proteins that perform a variety of dermatological functions and help maintain both the structure and function of the skin. More specifically, the sirtuins have been shown to be altered in multiple dermal cell types including dermal fibroblasts. The functions of dermal fibroblasts are extensive, and include playing a significant role in wound healing as well as helping to maintain the integrity of the skin. As dermal fibroblasts age, they can undergo a state of permanent cell cycle arrest, known as cellular senescence. This senescent process can occur as a result of various stressors, including oxidative stress, ultraviolet radiation -induced stress, and replicative stress. In recent years, there has been a growing interest in both enhancing the cutaneous fibroblast’s ability to facilitate wound healing and altering fibroblast cellular senescence. Thus, in this review, we examine the relationship between sirtuin signaling and dermal fibroblasts to understand how this family of proteins may modulate skin conditions ranging from the wound healing process to photocarcinogenesis associated with fibroblast senescence. Additionally, we offer supporting data from experiments examining the relationship between fibroblast senescence and sirtuin levels in an oxidative stress model indicating that senescent dermal fibroblasts exhibit diminished sirtuin levels. Furthermore, we survey the research on the role of sirtuins in specific dermatological disease states that where dermal fibroblast function has been implicated. Finally, we conclude with outlining potential clinical applications of sirtuins in dermatology. In sum, we find that the literature on the involvement of sirtuins in dermal fibroblasts is limited, with research still in its early stages. Nevertheless, intriguing preliminary findings merit additional investigation into the clinical implications of sirtuins in dermatology.

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“…Skin, the uppermost organ that protects the human body, is the surface upon which different environmental signals have the most immediate impact [9]. The number, quality, and distribution of melanin pigments produced by melanocytes determine the color of human skin, eyes, and hair, as well as how well they shield the skin from harmful ultraviolet (UV) rays and oxidative stress caused by numerous environmental pollutants.…”

Section: Skin As a Site Of Environmental Stimuli Exposurementioning

confidence: 99%

Skin Grafting, Cryopreservation, and Diseases: A Review Article

Adnan¹,

Jha²,

Verma³

et al. 2022

Cureus

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Food supplements may be consumed through diet and have been shown to modify skin functions, making them helpful in the management of skin aging. However, there are not many clinical trials that back up these assertions. The stratum corneum, which acts as the organism's contact with its environment, is the principal function of the epidermis of land vertebrates. Antioxidants are chemicals that slow down or prevent other molecules from oxidizing. In people's diets, their use has considerably expanded in recent years. Due to their benefits for health, nutrition, and therapy, natural antioxidants are increasingly being used in place of synthetic antioxidant components. A popular component thought to be an antioxidant is hydrolyzed collagen. With aging comes a steady loss of physiological integrity, capacity to handle stress from the inside out, and function. This is a byproduct of several intricate biological processes that are affected by diseases both local and systemic as well as constitutive and environmental variables. Systemic and constitutive (genetic) variables influence skin aging and its phenotypic manifestation. The biological process of skin aging is complicated and impacted by both external and endogenous causes. The primary contributor to skin cancer is sun exposure. Ultraviolet radiation from the sun can kill skin cells by directly absorbing DNA damage. The skin's hydration is a crucial factor that affects its mechanical and physical characteristics. This study looks at how the stratum corneum's molecular and macroscopic characteristics interact and change with skin wetness. Although there is little information written about them and even less is understood about them, moisturizers are a crucial component of a dermatologist's toolkit. There is a plethora of anticipated skin products on the market, but their true scientific function is yet unknown. These items play a well-known part in many skin problems, while occasionally being dismissed as simple cosmetics.

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Epigenetics of Cutaneous Sarcoma

Cited by 11 publications

References 122 publications

Epigenetic Modification of PD-1/PD-L1-Mediated Cancer Immunotherapy against Melanoma

Epigenetic Modification of PD-1/PD-L1-Mediated Cancer Immunotherapy against Melanoma

The role of sirtuins in dermal fibroblast function

Skin Grafting, Cryopreservation, and Diseases: A Review Article

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