Epithelial ovarian cancer: a cytokine propelled disease?

Malik, Sanjeev; Balkwill, Frances R.

doi:10.1038/bjc.1991.372

Cited by 54 publications

(25 citation statements)

References 42 publications

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“…Ovarian cancer has been proposed to be ''a cytokinepropelled disease'' based on the numerous cytokine receptors that are expressed in these tumors [7]. Interleukin-8 (IL-8) is a small (8 kDa) chemotactic cytokine mainly attracting and activating neutrophilic granulocytes, but it is also implicated in angiogenic events [8].…”

Section: Introductionmentioning

confidence: 99%

Vascular endothelial growth factor and interleukin-8 are associated with poor prognosis in epithelial ovarian cancer patients

Kassim

El-Salahy

Fayed

et al. 2004

Clinical Biochemistry

124

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Section: Introductionmentioning

confidence: 99%

Vascular endothelial growth factor and interleukin-8 are associated with poor prognosis in epithelial ovarian cancer patients

Kassim

El-Salahy

Fayed

et al. 2004

Clinical Biochemistry

124

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“…The exact biological relevance of local hormone production and expression of steroid receptors in ovarian cancers is still unresolved. Cytokines also seem to regulate both normal and malignant ovarian epithelium (Malik & Balkwill, 1991).…”

Section: Through the Fallopian Tubesmentioning

confidence: 99%

Hormonal aspects of epithelial ovarian cancer: review of epidemiological evidence

Riman

Persson

Nilsson

1998

Clinical Endocrinology

174

120

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“…Normal ovarian epithelial cells have an inherent ability to produce and respond to cytokines and growth factors, which are implicated in ovulation, steroidogenesis and other physiological processes (3)(4)(5)(6). In the normal ovary, the surface epithelium is repetitively disrupted and epithelial cells proliferate to heal this ovulation-associated wound.…”

Section: Introductionmentioning

confidence: 99%

“…It has long been recognized that wounding, since it creates a favorable environment for proliferation and involves the local release of cytokines, can act as a tumor growth promoter (7)(8)(9). Several cytokines are involved in autocrine and paracrine loops in ovarian malignancy (4)(5)(6). Abnormal expression of cytokines and their receptors in ovarian cancer patients has been widely documented.…”

Section: Introductionmentioning

confidence: 99%

Peritoneal Fluid Cytokines and the Differential Diagnosis of Benign and Malignant Ovarian Tumors and Residual/Recurrent Disease Examination

Chechlińska¹,

Kamińska²,

Markowska

et al. 2007

Int J Biol Markers

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This study aimed to assess the potential value of peritoneal fluid cytokine examination for the differential diagnosis of ovarian tumors and for evaluating residual or recurrent disease after treatment. The cytokines that are commonly elevated in ovarian cancer, VEGF, IL-6, bFGF, IL-8 and M-CSF, and a reference ovarian tumor marker, CA 125, were measured in peritoneal fluids of 53 previously untreated patients with epithelial ovarian cancer, 18 ovarian cancer patients after surgical treatment and chemotherapy, and 17 patients with benign epithelial ovarian tumors. Non-parametric statistical analysis of data was performed. Ovarian cancer peritoneal fluids, as compared to peritoneal fluids of patients with benign ovarian tumors, contained significantly higher concentrations of IL-6, VEGF and CA 125, and significantly lower concentrations of bFGF and M-CSF, but only the levels of IL-6 and VEGF were significantly higher in peritoneal fluids of stage I and II ovarian cancer patients than of patients with benign ovarian conditions. IL-6 at the cutoff level of 400 pg/mL discriminated benign and malignant ovarian tumors with 92% sensitivity and 60% specificity, while VEGF at the cutoff of 400 pg/mL had 90% sensitivity and 80% specificity. At the cutoff level of 1200 pg/mL, IL-6 had 84% sensitivity and 87% specificity. A radical decrease in local cytokine and CA 125 levels in patients after treatment was independent of therapy outcome. IL-6 and VEGF measurements in peritoneal fluids might be useful for the differential diagnosis of malignant and benign ovarian conditions, but not for residual or recurrent disease examination. (Int J Biol Markers 2007; 22: 172-80)

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Epithelial ovarian cancer: a cytokine propelled disease?

Cited by 54 publications

References 42 publications

Vascular endothelial growth factor and interleukin-8 are associated with poor prognosis in epithelial ovarian cancer patients

Vascular endothelial growth factor and interleukin-8 are associated with poor prognosis in epithelial ovarian cancer patients

Hormonal aspects of epithelial ovarian cancer: review of epidemiological evidence

Peritoneal Fluid Cytokines and the Differential Diagnosis of Benign and Malignant Ovarian Tumors and Residual/Recurrent Disease Examination

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