Epstein Barr virus: a prime candidate of breast cancer aetiology in Sudanese patients

Yahia, Zeinab A; Adam, Ameera A. M.; Elgizouli, Magdeldin; Hussein, Ayman A.; Masri, Mai; Kamal, M.; Mohamed, Hiba S.; Alzaki, Kamal; Elhassan, Ahmed M.; Hamad, Kamal; Ibrahim, Muntaser E.

doi:10.1186/1750-9378-9-9

Cited by 68 publications

(63 citation statements)

References 27 publications

(22 reference statements)

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“…This result is below the values reported in other studies conducted at a global level, which range from 21-55% of EBV DNA positivity, depending on the type of technique employed for viral DNA detection 4,19,40 . In works using some type of PCR, as in our study, low infection rates were detected, as in the trial by Xue, et al in 2003, who, using BZLF1 gene-specific reverse transcriptase PCR, detected viral DNA in 17% of breast cancer cases, and the work by Yahia, in 2014, who detected 11% of EBV DNA positivity in breast cancer cases using PCR with EBNA-1 gene-specific primers 41,42 . In Latin America, very few studies have assessed the presence of EBV in breast cancer, and have reported a rate of infection ranging from 6-31% 31,43 .…”

Section: Discussionsupporting

confidence: 69%

Presence of Human Papillomavirus and Epstein-Barr Virus in Breast Cancer Biopsies as Potential Risk Factors

Ladera¹,

Fernándes²,

López³

et al. 2022

GAMO

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Introduction: Breast cancer represents the leading cause of cancer-related death in the Venezuelan female population. Many risk factors favoring its appearance have been reported; however, human papillomavirus and Epstein-Barr virus have been associated in the past few decades as potential risk factors in the development of this malignancy. Objective: To detect the presence of human papillomavirus and Epstein-Barr virus in breast cancer biopsies in order to establish a possible link between infection with these viral agents and the development of this pathology. Methods: Fresh biopsies were collected from patients with breast cancer and patients with breast benign pathology attending the Hospital Universitario de Caracas for surgery. Human papillomavirus detection was made using the INNO-LIPA ® HPV Genotyping Extra commercial kit (Innogenetics), and Epstein-Barr virus genome was detected with Epstein-Barr Virus BMLF1 commercial kit (Maxim Biotech, Inc.). Results: 63.6 and 13.6% of breast cancer cases were positive for human papillomavirus and Epstein-Barr virus DNA, respectively, whereas the benign pathology samples had 4.5% positivity for each one of the viruses; 42.90% of breast cancer samples had mixed infection with low and high oncogenic risk human papillomavirus genotypes. Conclusion: We can suggest that human papillomavirus and Epstein-Barr virus are important risk factors for breast cancer; however, studies allowing for the role of these viruses in the development of the disease to be elucidated are required. (creativecommons.org/licenses/by-nc-nd/4.0/). HPV and EBV in breast cancer 104

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Section: Discussionsupporting

confidence: 69%

Presence of Human Papillomavirus and Epstein-Barr Virus in Breast Cancer Biopsies as Potential Risk Factors

Ladera¹,

Fernándes²,

López³

et al. 2022

GAMO

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“…2016; 11(3):e34806. (11,18,(36)(37)(38)(39)(40)(41)(42)(43)(44)(45)(46)(47)(48)(49)(50)(51)(52)(53). Table 1 shows a summary of the EBV-DNA positive subjects according to nationality, types of sample, and kinds of control tissue in the 20 selected studies.…”

Section: Resultsmentioning

confidence: 99%

Epstein-Barr Virus Infection and Risk of Breast Cancer: An Adaptive Meta-Analysis for Case-Control Studies

Bae

Kim

2016

Arch Clin Infect Dis

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Context: The association between 'Epstein-Barr' virus (EBV) and breast cancer risk still remains controversial. A Systemic Review (SR) published in 2012 reported that there might be a statistically significant association between EBV and risk of breast cancer. However, errors were found in the appraisal process of the concerned SR. Objectives:The aim of this report was to conduct an adaptive meta-analysis with additional extraction of relevant papers published up until September 2015.Data Sources: The lists of references, cited articles and related articles provided by PubMed were made using the articles selected in the previous SR.Study Selection: Among these articles, only case-control studies using Polymerase Chain Reaction (PCR) techniques to detect EBV DNA in tissues were selected. Data Extraction: The summary odds ratio (SOR) and the 95% confidence interval (CI) were calculated though meta-analysis.Results: A total of 20 case-control studies were selected, and the total numbers of subjects in the case and control groups were 1947 and 1010, respectively. The findings of this meta-analysis revealed that EBV infection might increase the risk of breast cancer (SOR = 3.84, 95% CI: 2.24-6.58; I-squared = 62.2%). Sub-group analyses by region, sample type, and control tissue showed that a statistical significance of the risk was still secured. Conclusions:The findings of the meta-epidemiological study support that EBV infection may increase the risk of breast cancer. Nested case-control studies are required in the future.

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“…EBV genomic sequences were detected in a large fraction of tested Sudanese breast cancer specimens, suggesting an association between EBV and breast carcinoma in Sudanese patients [71].…”

Section: Breast Cancer Genetics In Sudanmentioning

confidence: 97%

Epidemiology, Pathology, Management and Open Challenges of Breast Cancer in Central Sudan: A Prototypical Limited Resource African Setting

Mariani–Costantini¹,

Elhassan²,

Aceto³

et al. 2017

Breast Cancer - From Biology to Medicine

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Litle is known about breast cancer in Sudan. According to the recent data published by the Khartoum Cancer Registry, breast cancer was the most common cancer among Sudanese women. Generally, breast cancer in native African women is characterized by young age at onset, occurrence in multiparous premenopausal patients, advanced stage at diagnosis, large tumor size, high-grade and triple-negative phenotype, with correspondingly poor prognosis. In Sudan, it was reported that about 70% of the women diagnosed with breast cancer were younger than 50 years old. We present here data from local and international publications as well as primary information from the National Cancer Institute in Wad Medani (one of the only two cancer hospitals of the country, both located in Central Sudan in Khartoum and Wad Medani). We provide an up-to-date situation analysis of breast cancer in Central Sudan as an example for an African reality and the various open challenges of breast cancer in a limited resource seting. A beter understanding of breast cancer in black African women is of global relevance, as there is an alarming increase in breast cancer among young black women worldwide, and these patients have the lowest survival rates.

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Epstein Barr virus: a prime candidate of breast cancer aetiology in Sudanese patients

Cited by 68 publications

References 27 publications

Presence of Human Papillomavirus and Epstein-Barr Virus in Breast Cancer Biopsies as Potential Risk Factors

Presence of Human Papillomavirus and Epstein-Barr Virus in Breast Cancer Biopsies as Potential Risk Factors

Epstein-Barr Virus Infection and Risk of Breast Cancer: An Adaptive Meta-Analysis for Case-Control Studies

Epidemiology, Pathology, Management and Open Challenges of Breast Cancer in Central Sudan: A Prototypical Limited Resource African Setting

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