Epstein-Barr virus in nasal T-cell lymphomas in patients with lethal midline granuloma

Harabuchi, Yasuaki; Yamanaka, Noboru; Kataura, Akikatsu; Imai, Shosuke; Kinoshita, Toshibumi; Õsato, Toyoro

doi:10.1016/0140-6736(90)90002-m

Cited by 504 publications

(245 citation statements)

References 16 publications

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“…Our findings suggests that EBV-infected T cells might induce the accumulation and the phagocytosing behavior of histiocytes and macrophages. Such phagocytic histiocytes have not been recognized in the few examples ofEBV-infected T cell diseases, including most T cell lymphomas (6, 7), lethal midline granuloma (35), and Kawasaki-like disease (36). Thus, EBV-AHS represents a subset of EBV-infected T cell diseases characterized by the accumulation and proliferation ofhemophagocytic macrophages, as has been recognized in a particular type of T cell lymphoma (24).…”

Section: Resultsmentioning

confidence: 99%

Epstein-Barr virus-infected T lymphocytes in Epstein-Barr virus-associated hemophagocytic syndrome.

Kawaguchi¹,

Miyashita²,

Herbst³

et al. 1993

J. Clin. Invest.

180

114

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Section: Resultsmentioning

confidence: 99%

Epstein-Barr virus-infected T lymphocytes in Epstein-Barr virus-associated hemophagocytic syndrome.

Kawaguchi¹,

Miyashita²,

Herbst³

et al. 1993

J. Clin. Invest.

180

114

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“…The primary site of involvement is the nasal cavity, but sometimes similar neoplasms develop in extranasal sites [87]. Nasal NK cell lymphoma is almost always associated with EBV [88]. Similar to Hodgkin's lymphoma, nasal NK cell lymphoma patients have increased amounts of circulating EBV DNA in the plasma or serum [89], potentially because apoptotic proliferating tumour cells release EBV DNA [90].…”

Section: Nasal Nk Cell Lymphomamentioning

confidence: 99%

Measuring Epstein–Barr virus (EBV) load: the significance and application for each EBV‐associated disease

Kimura

Ito

Suzuki

et al. 2008

Reviews in Medical Virology

139

142

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Because Epstein-Barr virus (EBV) is ubiquitous and persists latently in lymphocytes, simply detecting EBV is insufficient to diagnose EBV-associated diseases. Therefore, measuring the EBV load is necessary to diagnose EBVassociated diseases and to explore EBV pathogenesis. Due to the diverse biology of EBV, the significance of measuring EBV DNA and the optimal type of specimen differ among EBV-associated diseases. Recent advances in molecular technology have enabled the EBV genome to be quantitated rapidly and accurately. Real-time polymerase chain reaction (PCR) is a rapid and reliable method to quantify DNA and is widely used not only as a diagnostic tool, but also as a management tool for EBV-associated diseases. However, each laboratory currently measures EBV load with its own ''homebrew'' system, and there is no consensus on sample type, sample preparation protocol, or assay units. The EBV real-time PCR assay system must be standardised for large-scale studies and international comparisons.

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“…Several lines of evidence have shown the association of latent Epstein-Barr virus (EBV) infection with the nasal-type, extranodal natural killer or T (NK/T)-cell lymphoma which occurs predominantly in Asia and Mexico (Harabuchi et al, 1990;Su et al, 1991;Jaffe et al, 1996;Harris et al, 1999). This type of lymphoma primarily affects the nasal cavity and skin, exhibiting histopathological features of angiodestructive infiltration and tissue necrosis (Su and Hsieh, 1992;Jaffe et al, 1996;Chan et al, 1997;Iwatsuki et al, 1997), and a frequent complication of haemophagocytic syndrome (Jaffe et al, 1983(Jaffe et al, , 1996.…”

mentioning

confidence: 99%

The latency pattern of Epstein–Barr virus infection and viral IL-10 expression in cutaneous natural killer/T-cell lymphomas

Iwatsuki

Oyama

et al. 2001

Br J Cancer

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SummaryThe nasal type, extranodal natural killer or T(NK/T)-cell lymphoma is usually associated with latent Epstein-Barr virus (EBV) infection. In order to elucidate the EBV gene expression patterns in vivo, we examined eight patients with cutaneous EBV-related NK/T-cell lymphomas, including six patients with a NK-cell phenotype and two patients with a T-cell phenotype. The implication of EBV in the skin lesions was determined by the presence of EBV-DNA, EBV-encoded nuclear RNA (EBER) and a clonality of EBV-DNA fragments containing the terminal repeats. Transcripts of EBV-encoded genes were screened by reverse transcription-polymerase chain reaction (RT-PCR), and confirmed by Southern blot hybridization. The expression of EBV-related antigens was examined by immunostaining using paraffinembedded tissue sections and cell pellets of EBV-positive cell lines. Our study demonstrated that all samples from the patients contained EBV nuclear antigen (EBNA)-1 mRNA which was transcribed using the Q promoter, whereas both the Q promoter and another upstream promoter (Cp/Wp) were used in EBV-positive cell lines, B95.8, Raji and Jiyoye. Latent membrane protein-1 (LMP-1) mRNA was detected in seven of eight patients and all cell lines, whereas EBNA-2 transcripts were found only in the cell lines. Immunostaining showed no LMP-1, EBNA-2 or ZEBRA antigens in the paraffin-embedded tissue sections, although they were positive in the cell line cells. Latent BHRF1 transcripts encoding bcl-2 homologue and BCRF1 transcripts encoding viral interleukin (vIL)-10 were detected in one and two of eight patients, respectively. A patient with NK-cell lymphoma expressing both transcripts died of rapid progression of the illness. Our results indicate that the restricted expression of the latency-associated EBV genes and the production of vIL-10 and bcl-2 homologue may favour tumour growth, evading the host immune surveillance.

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Epstein-Barr virus in nasal T-cell lymphomas in patients with lethal midline granuloma

Cited by 504 publications

References 16 publications

Epstein-Barr virus-infected T lymphocytes in Epstein-Barr virus-associated hemophagocytic syndrome.

Epstein-Barr virus-infected T lymphocytes in Epstein-Barr virus-associated hemophagocytic syndrome.

Measuring Epstein–Barr virus (EBV) load: the significance and application for each EBV‐associated disease

The latency pattern of Epstein–Barr virus infection and viral IL-10 expression in cutaneous natural killer/T-cell lymphomas

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