Epstein-Barr virus-positive Burkitt's lymphoma in a german woman during pregnancy

Bornkamm, Georg W.; Kaduk, B; Kachel, G.; Schneider, Ulrich; Fresen, K O; Schwanitz, Gesa; Hermanek, P

doi:10.1007/bf01008574

Cited by 54 publications

(17 citation statements)

References 46 publications

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“…Cell lines were grown at 37°C with 5% CO2 in RPMI 1640 medium supplemented with 10% fetal calf serum. The origins of the BL cell lines carrying a t(2;8) translocation have been described (1,2,14,25,28).…”

Section: Methodsmentioning

confidence: 99%

Three breakpoints of variant t(2;8) translocations in Burkitt's lymphoma cells fall within a region 140 kilobases distal from c-myc.

Henglein¹,

Synovzik²,

Groitl³

et al. 1989

Mol. Cell. Biol.

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The variant translocations t(2;8) in Burkitt's lymphoma cells join band q24 of chromosome 8, distal from c-myc, to the Igkappa locus, with considerable variation in the location of the breakpoints on chromosome 8. We report the cloning and molecular characterization of a chromosome 8 region, distal from the c-myc locus, which encompasses the breakpoints of the Burkitt's lymphoma cell lines BL64, BL21, and LY91 within 11 kilobase pairs, termed provisionally bvr-1 (Burkitt's variants' rearranging region 1). Using probes from the c-myc, the bvr-1, and the human pvt-1 loci obtained by chromosome walking coupled with pulsed-field gel electrophoresis, we have constructed a physical map of the region 3' of c-myc. We map bvr-1 and pvt-1 about 140 and 260 kilobase pairs, respectively, distal from c-myc.

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Section: Methodsmentioning

confidence: 99%

Three breakpoints of variant t(2;8) translocations in Burkitt's lymphoma cells fall within a region 140 kilobases distal from c-myc.

Henglein¹,

Synovzik²,

Groitl³

et al. 1989

Mol. Cell. Biol.

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show abstract

“…To define the sensitivity and specificity of interphase cytogenetics for the detection of cells carrying structural chromosomal aberrations in an excess of normal cells, we chose the Burkitt lymphoma cell line JI which was established from a female patient and carries the translocation t(2;8)(q32;q24) (Bornkamm et al, 1980). The control cell line has a normal male karyotype (46,XY).…”

Section: Resultsmentioning

confidence: 99%

“…The Burkitt lymphoma cell line JI carrying the t(2;8)(q32;q24) translocation was characterized earlier both by conventional G banding (Bornkamm et al, 1980) and FISH (Ried et al, 1992a).…”

Section: Cells and Cell Mixturementioning

confidence: 99%

Evaluation of the Utility of Interphase Cytogenetics to Detect Residual Cells with a Malignant Genotype in Mixed Cell Populations: A Burkitt Lymphoma Model

Ried¹,

Lengauer

Lipp

et al. 1993

DNA and Cell Biology

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“…The cell line Daudi [14] was used as a source of DNA for a prototypeVx1 gene. Similarly the cell lines GM607 (obtained from the Human Mutant Cell Repository, Camden, NJ), IARC/BL41 [15] and JI [16] were used as sources of DNA for prototypeVxI1,VxIII and VxIV genes, respectively.…”

Section: Cell Lines and Preparation Of Dnamentioning

confidence: 99%

Vχ gene segments rearranged in chronic lymphocytic leukemia are distributed over a large portion of the Vχ locus and do not show somatic mutation

Wagner

Luzzatto

1993

Eur J Immunol

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The structure of the human V kappa locus has been thoroughly investigated, but how the germ-line V kappa gene segment repertoire is actually sampled in kappa chain gene rearrangements is not known. In order to begin to answer this question we have polymerase chain reaction (PCR) amplified the rearranged V kappa genes from 26 kappa-expressing cases of chronic lymphocytic leukemia (CLL), followed by cloning and sequencing of the PCR product. All four V kappa gene families were represented amongst rearranged genes. In 25 out of 32 cases, the sequence of the rearranged gene matches perfectly that of 1 of 11 different known germ-line V kappa genes, indicating that no somatic mutation has occurred. Of the remaining 7 rearranged V kappa genes, 4 differ from known germ-line genes by only one or two amino acid residues; and 3 differ from each other and from all known sequences by 5 or more residues, suggesting that somatic mutation has occurred in these 3 cases. We conclude that: (a) in at least three-quarters of cases the rearranged genes are unmutated; (b) there is preferential usage of individual V kappa genes but not of V kappa gene families; and (c) the V kappa genes used are widely dispersed in the V kappa locus.

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Epstein-Barr virus-positive Burkitt's lymphoma in a german woman during pregnancy

Cited by 54 publications

References 46 publications

Three breakpoints of variant t(2;8) translocations in Burkitt's lymphoma cells fall within a region 140 kilobases distal from c-myc.

Three breakpoints of variant t(2;8) translocations in Burkitt's lymphoma cells fall within a region 140 kilobases distal from c-myc.

Evaluation of the Utility of Interphase Cytogenetics to Detect Residual Cells with a Malignant Genotype in Mixed Cell Populations: A Burkitt Lymphoma Model

Vχ gene segments rearranged in chronic lymphocytic leukemia are distributed over a large portion of the Vχ locus and do not show somatic mutation

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