Equation of State for Phospholipid Self-Assembly

Marsh, Derek

doi:10.1016/j.bpj.2015.11.012

Cited by 12 publications

(26 citation statements)

References 44 publications

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“…Second, it may affect the chemical potentials of the lipids (µ mv and µ s ). But the thermodynamics of general lipid self-assembly shows that micelles and SLBs are in thermodynamically equivalent states [44,45], suggesting that they have the same dependence on temperature and any resulting difference in µ mv − µ s should be largely independent of temperature. In addition, temperature can modulate the frequency shift ∆ f c by altering lipid packing density:…”

Section: Effect Of Temperaturementioning

confidence: 99%

Thermodynamic Modeling of Solvent-Assisted Lipid Bilayer Formation Process

Tae

Cho

et al. 2022

Micromachines

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The solvent-assisted lipid bilayer (SALB) formation method provides a simple and efficient, microfluidic-based strategy to fabricate supported lipid bilayers (SLBs) with rich compositional diversity on a wide range of solid supports. While various studies have been performed to characterize SLBs formed using the SALB method, relatively limited work has been carried out to understand the underlying mechanisms of SALB formation under various experimental conditions. Through thermodynamic modeling, we studied the experimental parameters that affect the SALB formation process, including substrate surface properties, initial lipid concentration, and temperature. It was found that all the parameters are critically important to successfully form high-quality SLBs. The model also helps to identify the range of parameter space within which conformal, homogeneous SLBs can be fabricated, and provides mechanistic guidance to optimize experimental conditions for lipid membrane-related applications.

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Section: Effect Of Temperaturementioning

confidence: 99%

Thermodynamic Modeling of Solvent-Assisted Lipid Bilayer Formation Process

Tae

Cho

et al. 2022

Micromachines

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“…As it is possible to appreciate, multiple utilities for these structures have been proposed, relevant for several biomedical and biotechnological applications. These studies coincide in the fact that is necessary to find a method which produces stable self-assembled phospholipid bilayers that can resist important changes in environmental conditions and remain in a functional state [ 13 , 14 ].…”

Section: Introductionmentioning

confidence: 99%

Thermal Response Analysis of Phospholipid Bilayers Using Ellipsometric Techniques

et al. 2017

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Biomimetic planar artificial membranes have been widely studied due to their multiple applications in several research fields. Their humectation and thermal response are crucial for reaching stability; these characteristics are related to the molecular organization inside the bilayer, which is affected by the aliphatic chain length, saturations, and molecule polarity, among others. Bilayer stability becomes a fundamental factor when technological devices are developed—like biosensors—based on those systems. Thermal studies were performed for different types of phosphatidylcholine (PC) molecules: two pure PC bilayers and four binary PC mixtures. These analyses were carried out through the detection of slight changes in their optical and structural parameters via Ellipsometry and Surface Plasmon Resonance (SPR) techniques. Phospholipid bilayers were prepared by Langmuir-Blodgett technique and deposited over a hydrophilic silicon wafer. Their molecular inclination degree, mobility, and stability of the different phases were detected and analyzed through bilayer thickness changes and their optical phase-amplitude response. Results show that certain binary lipid mixtures—with differences in its aliphatic chain length—present a co-existence of two thermal responses due to non-ideal mixing.

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“…In aqueous media, PLs molecules form aggregate structures by self-assembly course of action 8,9 . Spherical bilayers known as vesicles or liposomes are among of these structures 10,11 .…”

Section: Introductionmentioning

confidence: 99%

Coconut (Cocos nucifera L.) Lipids: Extraction and Characterization

Hudiyanti¹,

Khafiz²,

Anam³

2018

Orient. J. Chem

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Lipids extraction from dried coconut meat is conducted by maceration using chloroform/ methanol (2:1,v/v) and partition extraction with n-hexane/87% ethanol (3:1), and column chromatography. Lipids are analyzed using FTIR, GC-MS, and TLC. Results reveal that dryed coconut meat has 0.04% phospolipids, 0.22% of neutral lipids, and 0.04% of glycolipids and ceramides. Coconut phospolipids consist of phosphatidylcholine (PC), phosphatidylserine (PS), and/or phosphatidylethanolamine (PE) classes for the hydrophilic parts with dodecanoic acid (C12: 0), hexadecanoic acid (C16:0) and octadecanoic acid (C18: 0) as the lipophilic parts.

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Equation of State for Phospholipid Self-Assembly

Cited by 12 publications

References 44 publications

Thermodynamic Modeling of Solvent-Assisted Lipid Bilayer Formation Process

Thermodynamic Modeling of Solvent-Assisted Lipid Bilayer Formation Process

Thermal Response Analysis of Phospholipid Bilayers Using Ellipsometric Techniques

Coconut (Cocos nucifera L.) Lipids: Extraction and Characterization

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