Eradication of Propionibacterium acnes biofilms by plant extracts and putative identification of icariin, resveratrol and salidroside as active compounds

Coenye, Tom; Brackman, Gilles; Rigole, Petra; Witte, Evy De; Honraet, Kris; Rossel, Bart; Nelis, Hans

doi:10.1016/j.phymed.2011.10.005

Cited by 89 publications

(59 citation statements)

References 13 publications

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“…acnes is an obligate anaerobic organism that has capability to metabolize sebaceous triglycerides into fatty acids inside sebaceous gland. Also, due to the increased production of sebum, thickening of epidermis at the outlet of pilosebaceous unit occurs resulting in obstruction to the flow of sebum outwards and a comedo develops (Chomnawang et al, 2012;Coenye et al, 2012). Due to increased fatty acids content, the production of various reactive oxygen species (ROS) from the damaged follicular walls lead to the release of various cytokines like interleukin 8 (IL 8) and tumour necrosis factor (TNF α) as host immune response.…”

Section: Introductionmentioning

confidence: 99%

The potential of Leucosidea sericea against Propionibacterium acnes

Sharma

Kishore

Hussein

et al. 2014

Phytochemistry Letters

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Highlights:· Significant anti-bacterial and antioxidant activity displayed by crude extract of Leucosidea sericea and isolated compound. · Electron microscopy studies proved the lethal effects of plant extract and compound 5 on the cells of P. acnes. 2 Graphical abstractAntibacterial bioassay of ethanol extract of Leucosidea sericea and isolated compounds against Propionibacterium acnes. · AbstractThe present study reports on the potential of Leucosidea sericea addressing acne vulgaris.Four known compounds namely, phytol acetate, triacontanol, phytol and alpha kosin and one new compound namely, (E)-3,7,11,15-tetramethylheptadec-2-ene-1,1 7-diol have been isolated for the first time from this plant. The ethanol extract of leaves and one of the isolated compounds, alpha kosin exhibited significant minimum inhibitory concentration (with MIC values 15.7 and 1.9 µg/mL, respectively) against acne inducing bacteria, Propionibacterium acnes. Moreover, the transmission electron micrographs showed the efflux of intracellular content of the cells of P. acnes caused by plant extract and alpha kosin. The ethanol extract of L. sericea exhibited significant anti-inflammatory activity by suppressing interleukin 8 (IL 8) and tumour necrosis factor (TNF α) in coculture of human U937 cells and heat killed P.acnes at concentrations of 25.0, 12.5 and 6.2 µg/mL.

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Section: Introductionmentioning

confidence: 99%

The potential of Leucosidea sericea against Propionibacterium acnes

Sharma

Kishore

Hussein

et al. 2014

Phytochemistry Letters

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“…Though tetracyclines have not shown to significantly decrease biofilm mass, the combination of tetracycline and ellagic acid both in vivo and in vitro have demonstrated antibiofilm effects [24]. Coenye et al have subjected the P. acnes biofilm to extracts to 119 plant compounds and have found that five resulted in a potent antibiofilm activity: Epimedium brevicornum, Malus pumila, Polygonum cuspidatum, Rhodiola crenulata and Dolichos lablab [25]. The two chemical components isolated, icariin and resveratrol, were shown to exhibit marked antibiofilm activity against P. acnes.…”

Section: Disruption Of the Biofilmmentioning

confidence: 99%

The Role of Propionibacterium acnes Biofilm in Acne Vulgaris

Linfante¹,

Allawh²,

Allen³

2017

J Clin Exp Dermatol Res

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Acne vulgaris is traditionally known as the result of excess sebum production, follicular hyper keratinization, infection with Propionibacterium acnes, and follicular inflammation. However, the role of P. acnes is gaining momentum as the primary impetus in the pathogenesis of acne vulgaris. The biofilm-forming ability of P. acnes in vitro and on indwelling medical appliances and catheters has been known for quite some time, but only in the last decade has the presence of P. acnes biofilm been observed within the pilosebaceous unit. Since that time, the genome of the microbe has been sequenced, and genes responsible for quorum sensing and biofilm formation have been confirmed. As a result of biofilm formation, the virulence of P. acnes is amplified. Biofilm-encapsulated P. acnes upregulates the production of lipases, resulting in the production of free fatty acids. Free fatty acids as well as the biofilm itself bind the Toll-like receptors TLR2 and TLR4, activating the innate immune system, culminating in a robust inflammatory response. Biofilms also appear to significantly contribute to antibiotic resistance. Acting as a physical barrier for antibiotics as well as a commune for bacteria to exchange antibiotic resistance genes, the biofilm plays an integral role as the major hurdle to treating acne vulgaris. Traditional antimicrobials have not shown much promise in disruption of the biofilm. Other approaches have been investigated utilizing a variety of novel topical compounds that act to prevent or disrupt the biofilm as a therapeutic modality. The role of biofilm in the pathogenesis of acne vulgaris has remained underappreciated, but with global antimicrobial resistance looming, further attention may be warranted.

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“…However, redundancy of polysaccharides and the differences between the biosynthesis genes in various species are a serious limitation for possible drug development by use of this pathway as a target. The antibiofilm activity of some plant extracts (e.g., Rhodiola crenulata [arctic root], Epimedium brevicornum [rowdy lamb herb], and Polygonum cuspidatum [Japanese knotweed]) have been shown (Coenye et al, 2012).…”

Section: Nano-based Delivery Of Novel Anti-infectivesmentioning

confidence: 99%

Nanocarriers Against Bacterial Biofilms

Nafee

2015

Nanotechnology in Diagnosis, Treatment and Prophylaxis of Infectious Diseases

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Eradication of Propionibacterium acnes biofilms by plant extracts and putative identification of icariin, resveratrol and salidroside as active compounds

Cited by 89 publications

References 13 publications

The potential of Leucosidea sericea against Propionibacterium acnes

The potential of Leucosidea sericea against Propionibacterium acnes

The Role of Propionibacterium acnes Biofilm in Acne Vulgaris

Nanocarriers Against Bacterial Biofilms

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