The laser is an out-of-equilibrium nonlinear wave system where the interplay of the cavity geometry and nonlinear wave interactions, mediated by the gain medium, determines the self-organized oscillation frequencies and the associated spatial field patterns. In the steady state, a constant energy flux flows through the laser from the pump to the far field, with the ratio of the total output power to the input power determining the power-efficiency. While nonlinear wave interactions have been modelled and well understood since the early days of laser theory, their impact on the power-efficiency of a laser system is poorly understood. Here, we show that spatial hole burning interactions generally decrease the power efficiency. We then demonstrate how spatial hole burning interactions can be controlled by a spatially tailored pump profile, thereby boosting the power-efficiency, in some cases by orders of magnitude.Power-efficiency of lasers is a key property to be maximized to reduce energy requirements for on-chip applications, facilitate thermal management and pack lasers into smaller volumes. Earlier work on solid-state lasers addressed the quantum design of the gain medium and the optimization of carrier transport, demonstrating strong improvements in power-efficiency [1,2]. Far less systematic work has addressed the fundamental factors limiting the power efficiency of lasers and effective methods to overcome these, taking into account specific resonator properties. In particular, the impact of spatial hole burning interactions is poorly understood [3]. A case in point are the findings of Ref. [4], where the output power of microcavity quantum cascade lasers was found to increase exponentially with boundary deformation, resulting in a power enhancement over two orders of magnitude with respect to identical lasers of circular cross-section. After more than a decade of theoretical development, the fundamental factors behind this dramatic increase in power efficiency remain unknown. The goal of this paper is to provide a theoretical analysis of the mechanisms at work that enable such dramatic improvements in laser power efficiency.Typically, the pump power in a microlaser is deposited uniformly across the entire cavity area [ Fig. 1(a)] and lasing naturally occurs in cavity modes with the longest cavity lifetimes. Here we show the existence of a maximally power-efficient "optimally out-coupled mode" that may never turn on in a uniformly pumped cavity due to spatial-hole burning interactions. We further show that a non-uniform pump distribution designed to selectively pump the optimally out-coupled mode can lead to strong power enhancements.Spatially non-uniform pump distributions can be realized by fabricating patterned contacts [5], by spatially non-uniform doping in the case of current injection lasers [6,7], or by using spatial light modulators or special lenses for optically pumped lasers [8,9] (see Fig. 1(b)). We discuss the optimal spatial profile of the pump for a given resonator to maximize the power effic...