Erectile dysfunction among patients with chronic brucellosis

Safwat, Ahmed S.; Hasanain, Ahmad Farooq Alsayed; Mahran, Ali; Bakkar, Sally M.; Abdel-Aal, Sherif Mohamed; Nafee, Amany Mohamed Adawi

doi:10.1038/s41443-018-0068-9

Cited by 3 publications

(2 citation statements)

References 34 publications

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“…Our study found that the most common clinical manifestations in BPA were fever and dysuria, consistent with other studies. [20][21][22] The fever might be caused by inflammatory mediators in the blood, and the enlarged prostate might cause dysuria. Among our BPA cases, 37.5% had concurrent seminal vesicle infections, and one patient had epididymitis.…”

Section: Discussionmentioning

confidence: 99%

Brucella prostatic abscess: a retrospective study of eight cases and a literature review

Lan

Guo

et al. 2021

J Int Med Res

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Objective To present the clinical characteristics, diagnostics, and treatments for Brucella prostatic abscess (BPA). Methods We retrospectively analyzed eight BPA patients according to their vocations, age, clinical manifestations, laboratory test results, magnetic resonance imaging (MRI) findings, and treatments. Results The median age was 59 years. The most common clinical symptom was fever, followed by dysuria, erectile dysfunction, frequent urination, and urodynia. C-reactive protein (CRP) concentrations were significantly elevated in all patients, and in all by one patient, the erythrocyte sedimentation rate (ESR) was high. Prostate enlargement occurred in 87.5% of the patients. Lesions were located in the prostate peripheral (87.5%) and central zones (100%), with homogenous signals on T1-weighted imaging (T1WI) and a hyperintense signal on short tau inversion recovery (STIR). Patients had a small nodule or multiple nodules, with slight hyperintense to hyperintense signals on T2-weighted imaging (T2WI) and diffusion-weighted imaging (DWI). Three patients had pelvic effusion, and seminal vesicle (37.5%), epididymis (12.5%), and bladder (12.5%) infections occurred. All patients received rifampicin and doxycycline with levofloxacin; all lesions had resolved at follow-up ultrasonography. Conclusion Even in epidemic areas, the incidence of BPA is relatively rare. Our findings may increase the understanding of BPA and reduce misdiagnosis and mistreatment.

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Section: Discussionmentioning

confidence: 99%

Brucella prostatic abscess: a retrospective study of eight cases and a literature review

Lan

Guo

et al. 2021

J Int Med Res

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“…Only one woman was complicated by vaginitis and cervicitis, manifested by increased leucorrhea, menstrual irregularities and lower abdominal distension (Zhou et al, 2020). Epididymitis often coexists with orchitis, called epididymal-orchitis, and is clinically characterized by persistent fever, acute scrotal pain, swelling and congestion, and may be accompanied by rare testicular abscesses, atrophy and oligospermia (Gozdas and Bal, 2020).Safwat et alfound a significantly impaired reproductive system and a higher prevalence of erectile dysfunction (ED) in patients with chronic brucellosis, accounting for 70% of cases, and associated with testicular atrophy and serum decreased serum testosterone levels (Safwat et al, 2018).…”

Section: Genitourinary Systemmentioning

confidence: 99%

Research progress on complications of Brucellosis

Jun

Fan

Gao

et al. 2023

Front. Cell. Infect. Microbiol.

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Brucellosis is a common zoonotic disease that is widely spread worldwide and poses a major threat to human health. Clinically, it often presents with non-specific symptoms such as fever, excessive sweating, malaise, myalgia, arthralgia, loss of appetite, weight loss, and enlarged liver, spleen and lymph nodes. The disease has a long and recurrent course, often accumulating in multiple systems and organs. Of these, osteoarticular involvement is the most common complication, with a prevalence of approximately 2-77%, usually manifesting as spondylitis, sacroiliac arthritis and peripheral arthritis. Hepatosplenomegaly is seen in about 50% of patients with brucellosis, and gastrointestinal disturbances such as abdominal pain, nausea, and vomiting are common. Although respiratory involvement is less common, pneumonia, pleurisy, pleural effusion, and pulmonary nodules have been reported. Besides, approximately 2-20% of cases involve infections of the male genitourinary system, mainly manifesting as unilateral epididymal-orchitis and orchitis. The most serious complication facing brucellosis is cardiovascular involvement, and although the overall mortality rate of brucellosis is about 1% and the incidence of brucellosis endocarditis is less than 2%, more than 80% of deaths are associated with endocarditis. Furthermore, brucellosis is complicated by hematologic disease, with anemia occurring in approximately 20-53% of children during the acute phase. In addition, the neurological incidence of brucellosis is about 0.5-25%, mainly manifested as meningitis. In this study, we review the multisystem complications of brucellosis with the aim of improving early diagnosis, timely treatment and prevention of long-term complications.

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